Articles tagged "Renal ischemia"

2022 American Transplant Congress
Deletion of AIF-1 Promotes Kidney Reparative Macrophages and Prevents Fibrosis
I. Husain, A. Dangi, X. Luo
Duke University School of Medicine, Durham, NC
*Purpose: A major etiology contributing to poor allograft survival is the inevitable ischemic insult it incurs during transplantation. Macrophages are key players in ischemia-reperfusion injury,…
2022 American Transplant Congress
The Role of HNF4α in Renal Ischemia Reperfusion Injury
A. D. Saha
Toronto General Hospital Research Institute, Toronto, ON, Canada
*Purpose: Ischemia reperfusion injury (IRI) affects all solid organ transplants and impairs renal graft function. However, the mechanisms by which IRI affects grafts are incompletely…
2022 American Transplant Congress
Estrogen Receptor Beta Deletion is Protective in Renal Ischemia Reperfusion Injury but Pharmacologic Inhibition of Estrogen Receptor Beta is Not
C. OBrien¹, P. Hernandez², S. Concors², Z. Wang¹, G. Ge¹, W. Hancock³, M. Levine²
¹Surgery, University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Childrens Hospital of Philadelphia, Philadelphia, PA
*Purpose: Renal Ischemia Reperfusion Injury (IRI) contributes substantially to delayed graft function (DGF) in kidney transplantation. Prior work by our group has shown lower rates…
2022 American Transplant Congress
Implications of Accumulated Cold Time for US Kidney Transplantation Offer Acceptance
M. Barah¹, V. Kilambi², J. Friedewald¹, S. Mehrotra¹
¹Industrial Engineering and Management Sciences, Northwestern University, Evanston, IL, ²Department of Engineering and Applied Sciences, RAND Corporation, Arlington, VA
*Purpose: Reducing discard is a current focus in US transplantation of deceased donor kidneys. One cause for the discards is the avoidance of protracted cold…
2021 American Transplant Congress
Mapping Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI) in Kidney Transplant Biopsies Reveals Two Classes of Early AKI That Differ in Their Response-to-Wounding
P. Halloran¹, J. Reeve¹, G. Böhmig², O. Viklicky³, M. Myslak⁴, G. Gupta⁵, &. the INTERCOMEX Study Group⁶
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²Medical University of Vienna, Vienna, Austria, ³Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁴Pomeranian Medical University, Szczecin, Poland, ⁵Virginia Commonwealth University, Richmond, VA, ⁶., ., AB, Canada
*Purpose: We recently analyzed injury-induced molecular changes in kidney transplant biopsies using principal component analysis (PCA) (AJT https://doi.org/10.1111/ajt.16374). PC1 reflected all injury, PC2 distinguished early…
2021 American Transplant Congress
Estrogen Receptor Beta Deletion is Protective in Renal Ischemia Reperfusion Injury in a Renal Specific Manner
C. S. O'Brien, P. Hernandez, Z. Wang, G. Ge, W. Hancock, M. H. Levine
Surgery, University of Pennsylvania, Philadelphia, PA
*Purpose: Renal Ischemia Reperfusion Injury (IRI) is a major contributor to delayed graft function (DGF) in kidney transplantation. Previously, we have shown lower rates of…
2021 American Transplant Congress
Patterns and Inhibition of Cell Death During Static Cold Storage of Human Kidneys
J. R. DiRito¹, G. Chickering², J. T. Langford¹, D. Stern¹, S. Hosgood³, M. L. Nicholson³, E. Gavathiotis⁴, R. N. Kitsis⁵, M. Saltzman², J. S. Pober⁶, G. T. Tietjen⁷
¹Surgery, Yale School of Medicine, New Haven, CT, ²Biomedical Engineering, Yale University, New Haven, CT, ³Surgery, University of Cambridge, Cambridge, United Kingdom, ⁴Biochemistry and Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY, ⁵Surgery, Albert Einstein College of Medicine, Bronx, NY, ⁶Immunobiology, Yale University, New Haven, CT, ⁷Surgery and Biomedical Engineering, Yale School of Medicine, New Haven, CT
*Purpose: As the donor population continues to age and accumulate co-morbidities, more marginal kidneys are being retrieved for transplantation. However, estimates suggest that more than…
2021 American Transplant Congress
Sigma-1 Receptor Agonists are Renoprotective in Experimental Kidney Transplantation
A. Hosszu¹, T. Lakat¹, A. Toth¹, D. Balogh¹, J. Hodrea¹, L. J. Wagner², A. J. Szabo¹, A. Fekete¹
¹1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ²Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
*Purpose: Kidney transplantation (Tx) is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a…
2021 American Transplant Congress
Effect of Defibrotide on Kidney Ischemia Reperfusion Injury in a Preclinical Renal Transplant Model
P. Pine¹, Z. Sun², A. Matas³, J. Shi¹, A. Ebrahimnejad¹, M. Zanette⁴, P. Halloran⁵, J. S. Bromberg⁶, R. Hanvesakul⁷
¹Jazz Pharmaceuticals, Palo Alto, CA, ²Johns Hopkins Medicine, Baltimore, MD, ³Univ of Minnesota, Minneapolis, MN, ⁴Jazz Pharmaceuticals, Philadelphia, PA, ⁵Univ of Alberta, Edmonton, AB, Canada, ⁶Univ of Maryland School of Medicine, Baltimore, MD, ⁷Jazz Pharmaceuticals, Oxford, United Kingdom
*Purpose: Ischemia reperfusion injury (IRI) is a major contributor to graft failure. During organ removal and preservation, ischemia results in anaerobic respiration and cellular damage.…
2021 American Transplant Congress
Not Quite Right: The Irony of Longer Cold Times for Higher KDPI Kidneys
H. Ghali¹, D. Won¹, S. Yoon¹, A. Friedman²
¹Systems Science and Industrial Engineering, SUNY Binghamton, Binghamton, NY, ²LiveOnNY, New York, NY
*Purpose: To identify tactics for reduction of the kidney discard rate, we analyzed measurable, operational factors contributing to the key outcome of transplantation (TXP) or…