Articles tagged "Renal injury"

2016 American Transplant Congress
Many Discarded Kidneys Are Similar to Kidneys Accepted for Transplantation as Judged by Their Histologic Lesions and Molecular AKI Scores.
K. Famulski,¹ J. Reeve,¹ O. Aubert,² A. Loupy,² S. Niderhaus,³ J. Bromberg,³ P. Halloran.¹
¹University of Alberta, Edmonton, Canada; ²Necker Hospital, Paris, France; ³University of Maryland, Baltimore.
There is an increase in the number kidneys from older brain dead donors (DBD). Many are discarded based on conventional features (clinical or histology). Thus…
2016 American Transplant Congress
Influence of AKIN Stage on the Outcome of Deceased Donor Kidney Transplantation (DDKTx).
I. Qaqish, D. Haakinson, K. Reddy, M. Smith, H. Khamash, H. Raymond.
Mayo Clinic, Phoenix, AZ.
BackgroundTransplanting kidneys from donors with AKI is one of the methods to minimize the disparity between numbers of listed patient and donor pool. Our aim…
2016 American Transplant Congress
Role of TGF-β in Ischemia and Reperfusion Injury Induced Renal Fibrosis in Human Proximal Tubular Epithelial Cells.
R. Kapoor, N. Sheerin, J. Kirby.
Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Ischemia-reperfusion injury (IRI) leads to an irreversible damage to the tubular epithelium and promotes acute kidney injury (AKI) that is associated with progressive loss of…
2016 American Transplant Congress
Morbidity and Mortality of Early Post-Operative Acute Kidney Injury in Cardiothoracic Transplant Recipients.
J. Casale, A. Logan, C. Doligalski.
Tampa General Hospital, Tampa, FL.
Purpose: Early acute kidney injury (AKI) in cardiothoracic transplant recipients (CTTR) has not been well described; renal injury defined by the RIFLE criteria has been…
2016 American Transplant Congress
Comparing Renal Function After Liver Transplantation: Modified Piggyback versus Conventional Techniques without Venovenous Bypass.
J. Lee, J. Lee, S. Song, J. Lee, S.-K. Kwon, D. Han, M. Ju, G. Choi, J. Choi, M. Kim, S. Kim, D. Joo.
Surgery, Yonsei University College of Medicine, Seoul, Korea.
BackgroundThere are several options available for caval reconstruction in liver transplantation. Prior reports demonstrated that caval reconstruction technique could affect the renal function. However, there…
2016 American Transplant Congress
Impact of Donor AKI on Outcome Following High KDPI Deceased Donor Kidney Transplantation.
D. Haakinson,¹ I. Qaqish,² M. Smith,³ H. Khamash,² K. Reddy,¹ R. Heilman.²
¹Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ; ²Nephrology, Mayo Clinic Arizona, Phoenix, AZ; ³Pathology, Mayo Clinic Arizona, Phoenix, AZ.
Background: Transplanting deceased donor kidneys with AKI does not appear to have negative impact on graft survival, however the impact of AKI on high KDPI…
2016 American Transplant Congress
Donor AKI Does Not Adversely Affect the Outcome Following DCD Kidney Transplant.
I. Qaqish, D. Haakinson, K. Reddy, M. Smith, H. Khamash, R. Heilman.
Mayo Clinic, Phoenix, AZ.
BackgroundTransplanting kidneys from donation after cardiac death (DCD) donors has been associated with good outcome, but the impact of added donor AKI on the outcome…
2016 American Transplant Congress
Immunosuppressive Actions of CLI95 and CORM401 on TLR4 in Renal Ischemia Reperfusion Injury.
P. Luke,^1,2,5 G. Cepinskas,^1,4 H. Alharbi,^3,5 A. Haig,^3,5 R. Bhattacharjee.^1,2,5
¹Matthew Mailing Centre, London Health Sciences Centre, London, Canada; ²Surgery, Western University, London, Canada; ³Pathology and Laboratory Medicine, Western University, London, Canada.
Background: Kidneys from all donor sources are highly sensitive to ischemia-reperfusion injury (IRI). However, grafts donated after cardiac death (DCD) sustain an increased incidence of…
2016 American Transplant Congress
Reciprocal Effects of HDAC1 and HDAC2 Deletion on Renal Cold Ischemia Survival and Nuclear Co-Repressor Complex Expression.
D. Aufhauser Jr,¹ D. Murken,¹ Z. Wang,¹ A. Samanta,² G. Ge,¹ T. Bhatti,³ W. Hancock,^2,3 M. Levine.¹
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ³Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…
2016 American Transplant Congress
NecroX-7 Attenuates Ischemia-Reperfusion Renal Injury.
K. Lee,¹ Y. Ham,¹ J. Jeon,¹ Y. Chang,² S. Chung,¹ K. Na,¹ D. Choi.¹
¹Renal Division, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea; ²Internal Medicine, Daejeon Saint Mary Hospital, College of Medicine, Catholic University, Daejeon, Korea.
Introduction: Recently mitochondrial damage has been known to play a major role in various renal injury mechanisms including ischemia-reperfusion (IR) renal injury. Mitochondrial injury and…