Articles tagged "Renal injury"

2016 American Transplant Congress
Acute Kidney Injury (AKI) Associated with Chronic Kidney Disease (CKD) in Paediatric Non-Kidney Transplant Recipients.
C. Williams,^1,2 K. Borges,² T. Banh,² J. Vasilevska-Ristovska,² R. Chanchlani,^1,2 V. Ng,^1,2 A. Dipchand,^1,2 M. Solomon,^1,2 D. Hebert,^1,2 S. Kim,^1,3 B. Astor,⁴ R. Parekh.^1,2,3
¹University of Toronto, Toronto, Canada; ²Hospital for Sick Children, Toronto, Canada; ³University Health Network, Toronto, Canada; ⁴University of Wisconsin, Madison.
Background: Kidney dysfunction is common after solid organ transplantation; however, rates of post-transplant AKI and CKD in children are unknown.Objective: Determine rates of AKI and…
2016 American Transplant Congress
Mining the Human Proteome for Monitoring Renal Transplant Injury.
T. Sigdel,¹ Y. Gao,² J. He,² A. Wang,¹ C. Nicora,² D. Smith,² W. Qian,² D. Camp,² M. Sarwal.¹
¹Surgery, University of California-San Francisco, San Francisco; ²Pacific Northwest National Laboratory, Richland.
The human urinary proteome reflects systemic and inherent renal injury perturbations and can be harnessed to define biomarkers for different kidney transplant injury states. Through…
2016 American Transplant Congress
YKL-40 Predicts Renal Recovery in Deceased-Donor Transplantation.
J. Puthumana,¹ I. Hall,¹ P. Reese,² B. Schröppel,³ F. Weng,⁴ H. Thiessen-Philbrook,¹ M. Doshi,⁵ V. Rao,¹ C. Lee,⁶ J. Elias,⁶ L. Cantley,¹ C. Parikh.¹
¹Yale University School of Medicine, New Haven, CT; ²Renal-Electrolyte and Hypertension Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; ³Section of Nephrology, University Hospital, Ulm, Germany; ⁴Saint Barnabas Medical Center, Livingston, NJ; ⁵Division of Nephrology, Wayne State University School of Medicine, Detroit, MI; ⁶School of Medicine and Biological Sciences, Brown University, Providence, RI.
Background Deceased-donor kidneys with acute kidney injury (AKI) are often discarded for fear of poor transplantation outcomes. Donor biomarkers that predict post-transplant renal recovery could…
2016 American Transplant Congress
Deceased Donor Urine C5a Predicts Donor and Recipient Acute Kidney Injury.
B. Schroppel,¹ P. Heeger,² I. Hall,³ M. Doshi,⁴ F. Weng,⁵ P. Reese,⁶ C. Parikh.³
¹University Hospital, Ulm, Germany; ²Mount Sinai School of Medicine, New York; ³Program of Applied Translational Research, Yale University School of Medicine, New Haven; ⁴Wayne State University, Detroit; ⁵Barnabas Health, Livingston; ⁶University of Pennsylvania, Philadelphia.
Anti-complement therapies are currently being tested in human kidney transplantation to prevent DGF. In this large prospective, cohort study of 469 deceased organ donors, we…
2016 American Transplant Congress
Many Discarded Kidneys Are Similar to Kidneys Accepted for Transplantation as Judged by Their Histologic Lesions and Molecular AKI Scores.
K. Famulski,¹ J. Reeve,¹ O. Aubert,² A. Loupy,² S. Niderhaus,³ J. Bromberg,³ P. Halloran.¹
¹University of Alberta, Edmonton, Canada; ²Necker Hospital, Paris, France; ³University of Maryland, Baltimore.
There is an increase in the number kidneys from older brain dead donors (DBD). Many are discarded based on conventional features (clinical or histology). Thus…
2016 American Transplant Congress
Influence of AKIN Stage on the Outcome of Deceased Donor Kidney Transplantation (DDKTx).
I. Qaqish, D. Haakinson, K. Reddy, M. Smith, H. Khamash, H. Raymond.
Mayo Clinic, Phoenix, AZ.
BackgroundTransplanting kidneys from donors with AKI is one of the methods to minimize the disparity between numbers of listed patient and donor pool. Our aim…
2016 American Transplant Congress
Role of TGF-β in Ischemia and Reperfusion Injury Induced Renal Fibrosis in Human Proximal Tubular Epithelial Cells.
R. Kapoor, N. Sheerin, J. Kirby.
Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Ischemia-reperfusion injury (IRI) leads to an irreversible damage to the tubular epithelium and promotes acute kidney injury (AKI) that is associated with progressive loss of…
2016 American Transplant Congress
Morbidity and Mortality of Early Post-Operative Acute Kidney Injury in Cardiothoracic Transplant Recipients.
J. Casale, A. Logan, C. Doligalski.
Tampa General Hospital, Tampa, FL.
Purpose: Early acute kidney injury (AKI) in cardiothoracic transplant recipients (CTTR) has not been well described; renal injury defined by the RIFLE criteria has been…
2016 American Transplant Congress
Comparing Renal Function After Liver Transplantation: Modified Piggyback versus Conventional Techniques without Venovenous Bypass.
J. Lee, J. Lee, S. Song, J. Lee, S.-K. Kwon, D. Han, M. Ju, G. Choi, J. Choi, M. Kim, S. Kim, D. Joo.
Surgery, Yonsei University College of Medicine, Seoul, Korea.
BackgroundThere are several options available for caval reconstruction in liver transplantation. Prior reports demonstrated that caval reconstruction technique could affect the renal function. However, there…
2016 American Transplant Congress
Impact of Donor AKI on Outcome Following High KDPI Deceased Donor Kidney Transplantation.
D. Haakinson,¹ I. Qaqish,² M. Smith,³ H. Khamash,² K. Reddy,¹ R. Heilman.²
¹Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ; ²Nephrology, Mayo Clinic Arizona, Phoenix, AZ; ³Pathology, Mayo Clinic Arizona, Phoenix, AZ.
Background: Transplanting deceased donor kidneys with AKI does not appear to have negative impact on graft survival, however the impact of AKI on high KDPI…