2022 American Transplant Congress
Cell-Free DNA Concentration in Hypothermic Machine Perfusate is a Potential Rapid Marker for Kidney Graft Quality
1University of Florida, Gainesville, FL, 2University of Oklahoma Medical College, Oklahoma City, OK
*Purpose: The successful use of hypothermic machine perfusion (HMP) as a clinical modality for graft preservation prior to kidney transplantation (KTx) has generated a demand…2022 American Transplant Congress
Abnormal Kidney T Cell Metabolism During Ischemia Reperfusion Injury Can Be Modified to Improve Organ Structure and Function
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: T cells play an important role in the pathophysiology of kidney ischemia reperfusion injury (IRI). Metabolic programming of T cells, a rapidly evolving field,…2022 American Transplant Congress
M1 Macrophage Polarization in Antibody-Mediated Rejection After Renal Transplantation and the Intervention Study of Iguratimod
*Purpose: After kidney transplantation, Antibody Mediated Rejection (ABMR) is the main factor affecting the long-term survival of kidney transplantation. Previous studies have confirmed that macrophage…2022 American Transplant Congress
Technical Report to Increased Utilization of Injured Kidneys: CT Scan to Evaluate Organ and Reduce Discard
Surgery, Columbia Vagelos College of Physicians and Surgeons, New York, NY
*Purpose: To reduce discard of injured kidneys with parenchymal injury or perinephric hematoma . Young donors with good function but injury are at high risk…2022 American Transplant Congress
Anti-Fibrotic Property of Adipose Derived Regenerative Cells on Hydrogen Peroxide Induced Injury in Nrk-52e Cells
*Purpose: Adipose derived regenerative cells (ADRCs) are a heterogenous cell population derived from adipose tissue. These cells are composed of endothelial progenitor cells, pericytes, and…2022 American Transplant Congress
Kidney Nonprocurement in Deceased Donors with Acute Kidney Injury
*Purpose: Deceased donor acute kidney injury (AKI) is associated with high rates of kidney discard by transplant centers, despite evidence of excellent post-transplant outcomes. High…2022 American Transplant Congress
DCD and AKI Kidneys Experiencing DGF as a Platform for the Study of Adaptive Repair
*Purpose: AKI and DCD renal allografts are at high risk for DGF, yet the majority of these kidneys will eventually recover and attain good function…2022 American Transplant Congress
Diagnosis of Acute Graft Rejection After Kidney Transplantation Using Metabolome Analysis by Liquid Biopsy Approach
*Purpose: Presently, a definitive diagnosis of organ dysfunction after transplantation (such as acute rejection) is dependent on conventional histopathological evaluation using an invasive biopsy procedure…2022 American Transplant Congress
Donor-Derived Cell-Free DNA and Gene Expression Profiling for Surveillance of Renal Allograft Injury and Rejection
University of Maryland, Baltimore, MD
*Purpose: Donor derived cell free DNA (dd-cfDNA) and gene expression profiling offer non-invasive methods of early detection of graft injury and rejection in solid organ…2022 American Transplant Congress
Clusterin Protects Kidney Transplants from Ischemia-Reperfusion Injury by Modulating Neutrophil Infiltration
*Purpose: Ischemia-reperfusion injury (IRI) is inevitable during organ transplantation. Clusterin (CLU) has shown to be protective in IRI. Supplementation of storage solution with recombinant CLU…
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