Articles tagged "Renal injury"

2015 American Transplant Congress
Gene Expression Profiles Indicate That Many Discarded Kidneys Are Potentially Transplantable
K. Famulski,¹ S. Niederhaus,² J. Reeve,¹ J. Bromberg,² P. Halloran.
¹University of Alberta, Edmonton, Canada; ²University of Marlyland, Baltimore.
We previously showed that the molecular kidney injury-repair response (AKI score) in implantation core biopsies (Bx) predict future graft function better than histology. This could…
2015 American Transplant Congress
Characteristics and Consequences of Renal Allograft Rejections Due to Nonadherence
S. Patel, S. Kuten, J. Everett, J. Loucks-DeVos, L. Gaber, A. Gaber, R. Knight.
Houston Methodist Hospital, Houston.
Non-adherence (NA) with immunosuppressive medications is associated with increased healthcare costs, rejection risk, and graft loss. NA is difficult to measure, however, and is often…
2015 American Transplant Congress
Profound Effect of HDAC2 Deletion on Renal Ischemia-Reperfusion Injury Is Intrinsic to the Kidney and Includes Protection Against Cold Ischemia
D. Aufhauser, Jr.,¹ Z. Wang,¹ S. Cheraghlou,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA; ²Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; ³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Histone/protein deacetylases (HDACs) regulate gene expression by modifying chromatin accessibility and protein acetylation. We have previously found that deletion of HDAC2 protects from renal…
2015 American Transplant Congress
Proteasome Activation During Renal Cold Storage and Transplantation: A Novel Pathway for Mitochondrial Destruction?
N. Parajuli, L. MacMillan-Crow.
Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR.
Purpose: Renal cold storage (CS) is considered to be an alloantigen-independent risk factor for long-term transplant outcome. The precise molecular mechanisms responsible for CS-related renal…
2015 American Transplant Congress
The Role of Inflammasome Components in Renal Tubular Epithelial Cell Injury
S. Kasimsetty, A. Shigeoka, D. McKay.
Medicine, UCSD, La Jolla, CA.
Background:Inflammasomes are multiprotein complexes of pattern recognition receptors (PRRs) recognized as key triggers of cellular injury. TLRs provide the first signal for induction of the…
2015 American Transplant Congress
Acute Kidney Injury in the Early Post Kidney Transplant Period: Frequency, Etiology and Significance
B. Kiberd,¹ S. Cimen,¹ K. Tennankore.²
¹Surgery, Dalhousie University, Halifax, NS, Canada; ²Medicine, Dalhousie University, Halifax, NS, Canada.
Acute kidney injury (AKI) post kidney transplant has not been well described using current diagnostic criteria. The frequency and etiology of AKI in the first…
2015 American Transplant Congress
Role of Complement in Mediating Pericyte Trans-Differentiation in Resident Myofibroblasts: A New Hypothesis On Vascular Rarefaction in Renal Ischemia/Reperfusion (I/R) Injury
G. Castellano,¹ R. Franzin,¹ C. Divella,¹ A. Stasi,¹ A. Intini,¹ M. Gigante,¹ G. Lucarelli,¹ P. Ditonno,¹ M. Battaglia,¹ A. Crovace,¹ F. Staffieri,¹ G. Pertosa,¹ B. Oortwijn,² E. Amersfoort,² G. Grandaliano,³ L. Gesualdo.¹
¹University of Bari, Bari, Italy; ²Pharming Technologies NV, Leiden, Netherlands; ³University of Foggia, Foggia, Italy.
Vascular rarefaction is critical in the development of renal fibrosis. Pericytes regulate renal blood flow and might be an important source of renal interstitial myofibroblasts;…
2015 American Transplant Congress
Post-Transplant Changes in Serum Creatinine and Beta-2 Microglobulin Predict Acute Tubular Necrosis in the Early Post-Transplant Period
P. Liu,¹ A. Djamali,^1,2 D. Kaufman,^2,1 B. Astor.¹
¹Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI; ²Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Purpose: To evaluate the utility of early post-transplant changes in serum creatinine (SCr) and beta-2 microglobulin (B2M) in differentiating acute tubular necrosis (ATN) and other…
2015 American Transplant Congress
Mitochondrial Hydrogen Sulphide Donor Molecules Are More Effective Against Hypoxic Injury in Renal Tubular Epithelial Cells
G. Aboalsamh,^1,5 M. Saha,² I. Lobb,² J. Grewal,² P. Luke,^1,2,3 M. Wood,⁴ M. Whiteman,⁴ A. Sener.^1,2,3
¹Urology, University of Western Ontario, London, Canada; ²Microbiology and Immunology, University of Western Ontario, London, Canada; ³University of Western Ontario, University of Western Ontario, London, Canada; ⁴Experimental Therapeutics, University of Exeter Medical School, Exeter, England, United Kingdom; ⁵Surgery, King Abdulaziz Medical Center, Jeddah, Saudi Arabia.
Introduction: Ischemia reperfusion injury (IRI) in organ transplant often manifests itself as delayed graft function (DGF). DGF is associated with increased morbidity and deleterious effects…
2015 American Transplant Congress
Proximal Tubular Dysfunction Is Common After the First Year of Kidney Transplantation
G. Ensergueix,¹ J. Allard,¹ F. Saint-Marcoux,² B. Marin,³ S. Bodeau,² J.-C. Aldigier,¹ P. Marquet,² M. Essig.¹
¹Nephrology, Dialysis, Transplantation, University Hospital, Limoges, France; ²Pharmacology, Toxicology, University Hospital, Limoges, France; ³Epidemiology, Biostatistics, Methodology, University Hospital, Limoges, France.
Background: After the initial period of kidney transplantation, the prevalence of proximal tubular dysfunction (PTD) and its consequences are unknown. The aim of this study…