Influence of AKIN Stage on the Outcome of Deceased Donor Kidney Transplantation (DDKTx).
Mayo Clinic, Phoenix, AZ.
Meeting: 2016 American Transplant Congress
Abstract number: 274
Keywords: Graft function, Graft survival, Kidney transplantation, Renal injury
Session Information
Date: Monday, June 13, 2016
Session Name: Concurrent Session: Acute Kidney Injury and Recovery after Transplantation
Session Time: 4:30pm-6:00pm
Presentation Time: 5:30pm-5:42pm
Location: Ballroom C
Background
Transplanting kidneys from donors with AKI is one of the methods to minimize the disparity between numbers of listed patient and donor pool. Our aim is to determine the influence of AKIN classification of donors on outcomes following DDKTx.
Methods
We included all DDKTx transplanted at our center between January 2008 and February 2015. Using data from DonorNet, we classified all donors using the AKIN Staging (0-3). The primary outcome was graft survival at 1, 3 and 5 years post-transplant. The secondary outcome was delayed graft function (DGF), defined as requirement of dialysis or failure of creatinine drop more than 30% within 3 days of transplant. Survival analysis between groups were done using the Kaplan-Meier method. Continuous data shown as mean ±SD.
Results
The AKIN stage could be determined for 804 of 815 who received DDKTx during the study period. The risk of DGF progressively increased with increasing AKIN stage. 
Graft survival at 1, 3 and 5 years stratified by the AKIN stage was not different between the groups (p=0.19).
| 1 year | 3 year | 5 year | |
| AKIN 0 (n=169) | 93.5% | 84.3% | 77.8% |
| AKIN 1 (n=298) | 94.6% | 86.4% | 78.0% |
| AKIN 2 (n=138) | 95.5% | 87.7% | 82.1% |
| AKIN 3 (n=199) | 96.5% | 93.6% | 81.3% |
The mean donor age (±SD) for the four groups were 37.2±21 ,44.8±17.6, 41.2±16.1 and 35±14.6 years respectively (p<0.0001) and KDPI (±SD) were 42±28, 56±28, 52±27 and 49±24 respectively (p=0.017). There were no differences in rejection rate during the first year, BK infection, serum creatinine or eGFR(CKD EPI) at 1 year between the groups.
Conclusion
Our results shows that donor AKIN staging is strongly correlated with the risk of DGF, however increasing donor AKIN stage does not adversely effect graft survival.
CITATION INFORMATION: Qaqish I, Haakinson D, Reddy K, Smith M, Khamash H, Raymond H. Influence of AKIN Stage on the Outcome of Deceased Donor Kidney Transplantation (DDKTx). Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Qaqish I, Haakinson D, Reddy K, Smith M, Khamash H, Raymond H. Influence of AKIN Stage on the Outcome of Deceased Donor Kidney Transplantation (DDKTx). [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/influence-of-akin-stage-on-the-outcome-of-deceased-donor-kidney-transplantation-ddktx/. Accessed March 31, 2020.« Back to 2016 American Transplant Congress