Donor AKI Does Not Adversely Affect the Outcome Following DCD Kidney Transplant.
Mayo Clinic, Phoenix, AZ.
Meeting: 2016 American Transplant Congress
Abstract number: B186
Keywords: Donors, Graft function, Graft survival, non-heart-beating, Renal injury
Session Information
Date: Sunday, June 12, 2016
Session Name: Poster Session B: Kidney Transplantation: KDPI, HCV/Matching, Donor Age
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Background
Transplanting kidneys from donation after cardiac death (DCD) donors has been associated with good outcome, but the impact of added donor AKI on the outcome is not known. Our aim was to determine the clinical impact of donor AKI in DCD kidney transplantation.
Methods
We included all patients who received a DCD deceased donor kidney transplants done between February 2008 and April 2015. We used data from DonorNet to classify all donors using AKIN staging into two groups: AKIN stage 0-1 and AKIN stage 2-3. The primary outcome was death censored graft survival at 1 and 3 years post-transplant. Survival analysis and comparisons between groups were done using the Kaplan-Meier method. Continuous data shown as mean±SD.
Results
There were 815 DDKTx done during the study period of whom 120 (15%) patients received DCD DDTx. For the DCD cohort 78 (65%) were AKIN stage 0-1 group and 42 (35%) in the AKIN stage 2-3 group. Median (25-75%) follow up for the two groups were 2.3 (1.4-3.9) and 1.9 (1.1-3.2) years respectively. Death censored graft survival was not different between the two groups (p=0.44 by log rank).
| AKIN 0-1 (n=78) | AKIN 2-3 (n=42) | |
| 1 year | 97.3% | 97.2% |
| 3 year | 93.7% | 97.6% |
Other outcomes comparing the AKIN 0-1 group to AKIN 23 group including rejection during the first year( p=0.91), BK infection (p=0.88), chronic interstitial fibrosis (p=0.62) and tubular atrophy (p=0.92) on one year protocol biopsy were not different between the two cohorts.
Conclusion
Our analysis suggests that the addition of donor AKI does not have an adverse effect on the outcome following DCD kidney transplantation.
CITATION INFORMATION: Qaqish I, Haakinson D, Reddy K, Smith M, Khamash H, Heilman R. Donor AKI Does Not Adversely Affect the Outcome Following DCD Kidney Transplant. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Qaqish I, Haakinson D, Reddy K, Smith M, Khamash H, Heilman R. Donor AKI Does Not Adversely Affect the Outcome Following DCD Kidney Transplant. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/donor-aki-does-not-adversely-affect-the-outcome-following-dcd-kidney-transplant/. Accessed November 23, 2020.« Back to 2016 American Transplant Congress