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Donor AKI Does Not Adversely Affect the Outcome Following DCD Kidney Transplant.

I. Qaqish, D. Haakinson, K. Reddy, M. Smith, H. Khamash, R. Heilman.

Mayo Clinic, Phoenix, AZ.

Meeting: 2016 American Transplant Congress

Abstract number: B186

Keywords: Donors, Graft function, Graft survival, non-heart-beating, Renal injury

Session Information

Date: Sunday, June 12, 2016

Session Name: Poster Session B: Kidney Transplantation: KDPI, HCV/Matching, Donor Age

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Related Abstracts
  • Impact of Donor AKI on Outcome Following High KDPI Deceased Donor Kidney Transplantation.
  • Influence of AKIN Stage on the Outcome of Deceased Donor Kidney Transplantation (DDKTx).

Background

Transplanting kidneys from donation after cardiac death (DCD) donors has been associated with good outcome, but the impact of added donor AKI on the outcome is not known. Our aim was to determine the clinical impact of donor AKI in DCD kidney transplantation.

Methods

We included all patients who received a DCD deceased donor kidney transplants done between February 2008 and April 2015. We used data from DonorNet to classify all donors using AKIN staging into two groups: AKIN stage 0-1 and AKIN stage 2-3. The primary outcome was death censored graft survival at 1 and 3 years post-transplant. Survival analysis and comparisons between groups were done using the Kaplan-Meier method. Continuous data shown as mean±SD.

Results

There were 815 DDKTx done during the study period of whom 120 (15%) patients received DCD DDTx. For the DCD cohort 78 (65%) were AKIN stage 0-1 group and 42 (35%) in the AKIN stage 2-3 group. Median (25-75%) follow up for the two groups were 2.3 (1.4-3.9) and 1.9 (1.1-3.2) years respectively. Death censored graft survival was not different between the two groups (p=0.44 by log rank).

  AKIN 0-1 (n=78) AKIN 2-3 (n=42)
1 year 97.3% 97.2%
3 year 93.7% 97.6%

Other outcomes comparing the AKIN 0-1 group to AKIN 23 group including rejection during the first year( p=0.91), BK infection (p=0.88), chronic interstitial fibrosis (p=0.62) and tubular atrophy (p=0.92) on one year protocol biopsy were not different between the two cohorts.

Conclusion

Our analysis suggests that the addition of donor AKI does not have an adverse effect on the outcome following DCD kidney transplantation.

CITATION INFORMATION: Qaqish I, Haakinson D, Reddy K, Smith M, Khamash H, Heilman R. Donor AKI Does Not Adversely Affect the Outcome Following DCD Kidney Transplant. Am J Transplant. 2016;16 (suppl 3).

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To cite this abstract in AMA style:

Qaqish I, Haakinson D, Reddy K, Smith M, Khamash H, Heilman R. Donor AKI Does Not Adversely Affect the Outcome Following DCD Kidney Transplant. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/donor-aki-does-not-adversely-affect-the-outcome-following-dcd-kidney-transplant/. Accessed March 4, 2021.

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