ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2015 American Transplant Congress

    Late Rejection in Pediatric Heart Transplantation: The Importance of Medical Adherence

    A. Letica, W. Zuckerman, L. Addonizio, J. McAllister, T. Lee, M. Richmond.

    Division of Pediatric Cardiology, Columbia University, New York, NY.

    While the incidence of early rejection (<1 yr post-transplant) after pediatric heart transplant (HT) has decreased, late rejection (> 1 yr post-transplant) remains a constant…
  • 2015 American Transplant Congress

    Late Antibody-Mediated Rejection in a Large Cross-Sectional Cohort of Kidney Transplant Recipients – Results of the Screening Phase of the BORTEJECT Study

    F. Eskandary,1 G. Bond,1 H. Regele,2 N. Kozakowski,2 Z. Kikic,1 M. Wahrmann,1 H. Haslacher,3 R. Oberbauer,1 V. Ramassar,4 P. Halloran,4 G. Böhmig.1

    1Nephrology and Dialysis, Medical University Vienna, Vienna, Austria; 2Clinical Institute of Pathology, Medical University Vienna, Vienna, Austria; 3Department of Laboratory Medicine, Medical University Vienna, Vienna, Austria; 44Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.

    Antibody-mediated rejection (ABMR) is well established to be a leading cause of graft failure. Here, we investigated the prevalence of late ABMR in a large…
  • 2015 American Transplant Congress

    Intra-Renal Cytokine Measurement Detected During Kidney Allograft Biopsies Portend Severity of Histological Injury

    N. Leca, S. Anderson, K. Muczynski.

    Division of Nephrology, University of Washington, Seattle, WA.

    Histological changes observed on renal allograft biopsies, although considered the current standard for evaluation of allograft injury, lack specificity and disease activity assessment. We devised…
  • 2015 American Transplant Congress

    Outcomes of Kidney Transplantation of ABO- and Crossmatch-Incompatible Recipient-Donor Pairs Entered in Kidney Paired Donation Program

    D. Dadhania, M. Charlton, M. Aull, R. Friedlander, T. Muthukumar, J. Lee, M. Goris, D. Serur, S. Kapur, V. Sharma.

    Transplantation Medicine, Weill Cornell Medical Center, New York, NY.

    Kidney Paired Donation (KPD) enables ABO-incompatible (ABOI) and crossmatch-incompatible (XMI) patients to undergo transplantation using a 'more compatible' donor. Identification of factors that predict early…
  • 2015 American Transplant Congress

    Monocyte Recruitment to HLA Class I Antibody-Activated Endothelial Cells Is Dependent Upon mTOR

    S. Salehi, E. Reed.

    Pathology & Laboratory Medicine, UCLA, Los Angeles, CA.

    Aim: Antibody-mediated rejection (AMR) persists as a major issue affecting solid organ transplants. The purpose of this study was to investigate the proximal signaling events…
  • 2015 American Transplant Congress

    Changes in Donor Specific Antibodies (DSA) First Year After Kidney Transplant (KTX): Implications for Graft Histology and Survival

    F. Cosio,1 C. Schinstock,1 L. Cornell,3 F. de Teresa,1 M. Stegall.2

    1Nephrology, Mayo Clinic, Rochester, MN; 2Surgery, Mayo Clinic, Rochester, MN; 3Pathology, Mayo Clinic, Rochester, MN.

    Introduction. De novo DSA post-KTx is associated with high risk of chronic antibody mediated rejection (cAMR) and reduced graft survival. DSA changes during first year…
  • 2015 American Transplant Congress

    First Clinical Data With an Improved C1q-Luminex® Assay

    A. Roodenburg,2 J. Bamoulid,1 O. Staeck,1 C. Schoenemann,2 N. Lachmann,2 K. Budde.1

    1Nephrology, Charite Hospital, Berlin, Germany; 2HLA Laboratory, Charite Hospital, Berlin, Germany.

    Background: Chronic allograft dysfunction remains the main obstacle for long-term success of kidney transplantation. Immunological factors, in particular HLA-antibodies, contribute to long-term allograft loss. Identification…
  • 2015 American Transplant Congress

    The Best Regimen With Rituximab for ABO-Incompatible Living Donor Liver Transplantation

    H. Egawa,1 K. Umeshita,2 S. Uemoto.3

    1Surgery, Tokyo Women's Medical University, Tokyo, Japan; 2Osaka University, Suita, Japan; 3Kyoto University, Kyoto, Japan.

    Rituximab made a great progress on outcomes of ABO-incompatible living donor liver transplantation (ABO-I LDLT). Although Japanese multicenter study group published efficacy and safety of…
  • 2015 American Transplant Congress

    Burden of Early Antibody-Mediated Rejection (AMR): Complications, Resource Utilization and Cost-Differential in Treatment of AMR

    R. Banga,1 C. Schinstock,1 A. Boscoe,4 M. Hathcock,3 W. Kremers,3 M. Stegall.2

    1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN; 2Division of Transplantation Surgery, Mayo Clinic, Rochester, MN; 3Division of Biostatistics, Mayo Clinic, Rochester, MN; 4Health Outcomes Research, Alexion Pharmaceuticals, Cheshire, CT.

    Early antibody-mediated rejection (AMR) is common in positive crossmatch kidney transplants (+XMKTx). The current study determined the complications, resource utilization and cost associated with early,…
  • 2015 American Transplant Congress

    Interrogation of Plasma Cell-Rich Acute Rejection in Human Kidney Allografts by Whole Transcriptome Sequencing

    L. Mesnard, F. Campagne, H. Yang, D. Dadhania, J. Lee, S. Seshan, M. Suthanthiran, T. Muthukumar.

    Weill Medical College of Cornell University, New York.

    Plasma cell-rich acute rejection (PCRAR, plasma cells constituting >20% of the allograft infiltrating cells) portends poor prognosis.To gain better mechanistic insights and develop diagnostic biomarkers,…
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