2015 American Transplant Congress
Impact of Subclinical Rejection (SCR) and Acute Clinical (ACR) in Renal Transplant Recipients
University of Pittsburgh Medical Center, Pittsburgh, PA.
The importance of diagnosing subclinical rejection and its short and long term impact remains controversial.We prospectively evaluated 296 patients who had a kidney transplant at…2015 American Transplant Congress
Noninvasive Diagnostic and Predictive Value in Renal Transplant Recipients by Measurement of Urine BCA-1
ObjectiveTo investigate the relationship between early-stage renal acute rejection and the level of BCA-1 in urine, explore the diagnostic value and noninvasive monitoring in early…2015 American Transplant Congress
Variables Related to the Development of Donor Specific Antibodies (DSA) Post-Kidney Transplant (KTx): Implications for Late Graft Histology and Survival
1Medicine, Mayo Clinic, Rochester, MN; 2Surgery, Mayo Clinic, Rochester, MN.
Introduction. The incidence of de novo DSA increases post-KTx. DSA is associated to reduced graft survival likely due to chronic antibody mediated rejection (cAMR). However,…2015 American Transplant Congress
DEPTOR Is Expressed in CD4+ T Cells and Modulates Effector Responses and Allograft Rejection
Transplant Research Program, Boston Children's Hospital, Boston, MA.
DEPTOR is an evolutionarily conserved, first-in-kind cell intrinsic factor with potential to regulate the activity of multiple intracellular signaling pathways. However, its biology in T…2015 American Transplant Congress
Donor Specific Expansion of Regulatory T-Cells Was Associated With Allograft Tolerance Induced By Transient Mixed Chimerism in Nonhuman Primates
Transplant Center, Massachusetts General Hospital, Boston, MA.
Background: We have previously reported successful induction of solid organ allograft tolerance in nonhuman primates (NHP) via a mixed chimerism approach. Since these recipients achieved…2015 American Transplant Congress
CD27low NK Cells Prolong Allograft Survival in Mice By Inhibiting CD8+ T Cell Responses Through Controlling Graft-Derived Donor DCs
The underlying mechanisms by which distinct NK cell subsets promote either allograft rejection or survival remain unclear. Here, we tested the hypothesis that distinctively mature…2015 American Transplant Congress
Depression of Complement Regulatory Factors in Human and Rat Renal Grafts in Association With Progress of Acute Cellular Rejection
Introduction and ObjectiveIt is commonly known that complements play important roles in antibody mediated rejection in renal transplantation. However, the association of complements with progression…2015 American Transplant Congress
The Impact of Microcirculation Inflammation in Predicting Treatment Response for Late Onset Antibody Mediated Rejection
BackgroundThere have been marked advances of immunosuppression. However, management of late onset antibody-mediated rejection (AMR) after 6 months is still challenging. Despite important diagnostic and…2015 American Transplant Congress
Effect of Antibody Mediated Rejection on Long-Term Renal Allograft Function
Transplant Institute, Tulane University, New Orleans, LA.
Historically we had poor understanding of chronic rejection attributing it to hypertension and non-compliance. However in the last decade we have begun to understand the…2015 American Transplant Congress
Aging Enhances Immunosuppressives Capacities of Tacrolimus By Functional Changes of CD4+ T-Cells
Immunosenescence has broad consequences on alloimmunity and immunosuppression in the elderly may require age-adaptation. Here, we investigated the influence of aging on the effectivity of…
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