Effect of Antibody Mediated Rejection on Long-Term Renal Allograft Function
Transplant Institute, Tulane University, New Orleans, LA.
Meeting: 2015 American Transplant Congress
Abstract number: A134
Keywords: Adverse effects, African-American, Rejection
Session Information
Session Name: Poster Session A: Kidney Antibody Mediated Rejection
Session Type: Poster Session
Date: Saturday, May 2, 2015
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Exhibit Hall E
Historically we had poor understanding of chronic rejection attributing it to hypertension and non-compliance. However in the last decade we have begun to understand the impact of antibody mediated rejection on chronic rejection. This study examines the incidence and effect of antibody-mediated rejection (AMR) on chronic rejection and allograft function.
Methods: Retrospective analysis of 719 renal transplants performed in an inner city transplant center. AMR patients were examined for demographic associations and outcomes.
Results: Table 1 examines the demographics of the AMR population.
Patients (N) | AA Race (%) | Age (yrs) | Male Gender (%) | SLE (N) | Prior Transplant (%) | HLA Mismatch (N) | |
AMR | 43 | 95 | 44.6 | 72 | 5 | 10 | 4.25 |
No AMR | 675 | 60 | 50.3 | 59 | 3 | 13 | 3.77 |
p value | p<0.0001 | 0.006 | 0.093 | 0.044 | 0.682 | 0.091 |
Patients (N) | Rejections (N) | Time to Rejection (yrs) | Chronic Rejection (%) | Graft Failure (%) | Death (%) | Follow up (yrs) | |
AMR | 43 | 2.49 | 1.25 | 53 | 37 | 19 | 3.66 |
No AMR | 675 | 1.25 | 1.13 | 19 | 14 | 14 | 3.58 |
p value | <0.0001 | 0.654 | <0.001 | <0.0001 | 0.427 | 0.83 |
Conclusions: AMR occurred in a high-risk population of younger AA patients with an association with SLE and lower socioeconomics. What was most worrisome was the 100% of the AMR patients that developed chronic rejection were AA. This indicates AAs especially with lower socioeconomics should be the focus of considerable efforts to insure appropriate resource utilization of a scarce resource.
To cite this abstract in AMA style:
John M, Smith A, Dortonne I, Paramesh A, Killackey M, Lee B, Zhang R, Buell J. Effect of Antibody Mediated Rejection on Long-Term Renal Allograft Function [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/effect-of-antibody-mediated-rejection-on-long-term-renal-allograft-function/. Accessed December 11, 2024.« Back to 2015 American Transplant Congress