Session Name: Poster Session A: Kidney Antibody Mediated Rejection
Date: Saturday, May 2, 2015
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Exhibit Hall E
Historically we had poor understanding of chronic rejection attributing it to hypertension and non-compliance. However in the last decade we have begun to understand the impact of antibody mediated rejection on chronic rejection. This study examines the incidence and effect of antibody-mediated rejection (AMR) on chronic rejection and allograft function.
Methods: Retrospective analysis of 719 renal transplants performed in an inner city transplant center. AMR patients were examined for demographic associations and outcomes.
Results: Table 1 examines the demographics of the AMR population.
|Patients (N)||AA Race (%)||Age (yrs)||Male Gender (%)||SLE (N)||Prior Transplant (%)||HLA Mismatch (N)|
|Patients (N)||Rejections (N)||Time to Rejection (yrs)||Chronic Rejection (%)||Graft Failure (%)||Death (%)||Follow up (yrs)|
Conclusions: AMR occurred in a high-risk population of younger AA patients with an association with SLE and lower socioeconomics. What was most worrisome was the 100% of the AMR patients that developed chronic rejection were AA. This indicates AAs especially with lower socioeconomics should be the focus of considerable efforts to insure appropriate resource utilization of a scarce resource.
To cite this abstract in AMA style:John M, Smith A, Dortonne I, Paramesh A, Killackey M, Lee B, Zhang R, Buell J. Effect of Antibody Mediated Rejection on Long-Term Renal Allograft Function [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/effect-of-antibody-mediated-rejection-on-long-term-renal-allograft-function/. Accessed July 30, 2021.
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