Articles tagged "Rejection"

2015 American Transplant Congress
Distinct Subtypes of Rejection in a Novel Non Human Primate Model of Sensitization
C. Burghuber,^1,2 J. Kwun,^1,3 F. Leopardi,³ A. Gibby,¹ A. Farris,¹ N. Iwakoshi,¹ S. Knechtle.^1,3
¹Emory University, Atlanta, GA; ²Medical University Vienna, Vienna, Austria; ³Duke University, Durham, NC.
[Background] Preformed and newly formed alloantibody post transplantation (TX) can significantly deteriorate graft survival. Patterns of humoral rejection in sensitized patients varies significantly due to…
2015 American Transplant Congress
Differentially Expressed IL-6Rα and GP130 Genes in Kidney Biopsies (Bxs) Suggests Different Roles of IL-6 Signaling in Antibody (ABMR)- and Cell (CMR)-Mediated Rejection
H. Zhang,¹ D. Thomas,¹ J. Kowalewska,² E. Suviolahti,¹ H. Shafi,² C. Nast,² A. Gertych,² A. Vo,¹ M. Haas,² S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: IL-6 exerts immunoregulatory properties through IL-6 receptors, IL-6Rα and gp130. Our previous studies suggested the involvement of antibody-dependent cellular cytotoxicity (ADCC) and its related…
2015 American Transplant Congress
Neogenin Functions as a Chemokinetic Receptor on Activated CD4+ T Lymphocytes
L. Boneschansker,¹ H. Nakayama,¹ M. Eisenga,¹ M. Klagsbrun,¹ D. Irimia,² D. Briscoe.¹
¹Boston Children's Hospital, Boston; ²Massachusetts General Hospital, Boston.
Increasing data indicates that axonal guidance cues play a critical role in immunity, both in activation, migration as well as in the process of inflammation…
2015 American Transplant Congress
A Prospective Study of Renal Function and Histological Changes in Renal Transplant Recipients With Acute Clinical and Subclinical Rejection
S. Chen,¹ R. Mehta,¹ P. Sood,¹ P. Randhawa,² N. Shah,¹ C. Wu,¹ A. Tevar,³ S. Hariharan.¹
¹Nephrology, University of Pittsburgh Medical Center, Pittsburgh, PA; ²Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA; ³Transplant Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Background: To study the impact on renal function and histological changes in patients(pts) with acute clinical rejection(ACR) and subclinical rejection(SCR) from 3 to 12 month(m)…
2015 American Transplant Congress
Renal Outcomes of Cross Match Positive Simultaneous Liver Kidney (SLK) Transplant Recipients Compared to Cross Match Positive Kidney Allograft Recipients
S. Vaishnav,¹ T. Taber,¹ W. Goggins,² S. Nagaraju,² J. Fridell,² A. Sharfuddin,¹ M. Yaqub,¹ D. Mishler,¹ M. Mujtaba.¹
¹IUSM, IU Health, Indianapolis, IN; ²Surgery, Transplant, Indiana University School of Medicine, Indianapolis, IN.
The protective role of liver in cross-match(XM) positive SLK recipients and its impact on the incidence of renal antibody mediated rejection (AMR) is unclear.A retrospective…
2015 American Transplant Congress
Pretransplant Antibodies Against Angiotensin II Type 1 Receptor in Renal Transplantation: Preliminary Data from the KNOW-KT Study
K. Huh,¹ J. Lee,¹ Y. Park,² Y. Kim,¹ C. Ahn.³
¹Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; ²Department of Laboratory Medicine, Yonsei University Health System, Seoul, Republic of Korea; ³Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
BackgroundThe antibodies (Abs) against angiotensin II type 1 receptor (AT1R) have been suggested as a risk factor for graft failure and acute rejection. However, incidence…
2015 American Transplant Congress
Thymoglobulin Versus IL2RA: Three Year Results of a Randomized Controlled Trial
N. Pilch, H. Meadows, D. Taber, J. Fleming, C. Mardis, S. Nadig, J. McGillicuddy, T. Srinivas, C. Bratton, P. Baliga, K. Chavin.
Transplant, MUSC, Charleston, SC.
This is a three year follow-up of a prospective, randomized controlled trial (RCT) to determine the safety and efficacy of induction with rabbit antithymocyte globulin…
2015 American Transplant Congress
Constitutively Upregulated Expression of Complement and Matrix Transcripts in Kidney Transplant Recipients Who Develop Acute Rejection
K. Keslar,¹ J. Reid-Adam,⁴ E. Kwon,⁴ D. Hricik,⁵ E. Poggio,^2,3 P. Heeger,⁴ R. Fairchild.^1,3
¹Immunology, Cleveland Clinic; ²Nephrology, Cleveland Clinic; ³Glickman Urological Institute and Transplant Center, Cleveland Clinic, Cleveland, OH; ⁴Icahn School of Medicine, Mount Sinai, New York, NY; ⁵Nephrology, UH Case Medical Center, Cleveland, OH.
Identification of kidney transplants at elevated risk of acute rejection (AR) and/or chronic injury prior to loss of kidney function (GFR) could guide therapies to…
2015 American Transplant Congress
Clinicopathological Scenarios (CPS) Defined by Viremia, Creatinine and Histology in Polyomavirus Nephropathy Differ in 1st and 2nd (Follow-Up) Biopsy
C. Drachenberg, M. Chaudhry, F. Yang, R. Ugarte, A. Haririan, M. Mavanur, C. Cangro, B. Thomas, N. Costa, E. Ramos, M. Weir, J. Papadimitriou.
Pathology and Medicine, University of Maryland School of Medicine, Baltimore, MD.
Studies of sequential kidney biopsies (KB) after the diagnosis of polyomavirus allograft nephropathy (PVN) are scarce and clinicopathological evolution of PVN poorly understood. In practice…
2015 American Transplant Congress
Impact of HLA Antibody Monitoring After Kidney Transplantation
S. Rao,¹ M. Ghanta,¹ H. Parekh,² A. Gillespie,¹ I. Lee,¹ S. Geier,² K. Lau,³ S. Karhadkar,³ A. Di Carlo,³ S. Constantinescu.¹
¹Nephrology, Temple Univesity School of Medicine, Philadelphia, PA; ²Pathology, Temple Univesity School of Medicine, Philadelphia, PA; ³Surgery, Temple Univesity School of Medicine, Philadelphia, PA.
The impact of donor specific antibodies (DSA) and optimal therapeutic intervention for DSA in kidney transplant (KT) recipients has been reported with variable results. We…