ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2016 American Transplant Congress

    Higher Pre-Transplant HDL Levels Are Associated with Decreased Acute Rejection Following Kidney Transplant.

    J. Hagopian,1 D. Brennan,2 K. Lentine,3 T. Horwedel.1

    1Barnes Jewish Hospital, St. Louis; 2Washington University, St. Louis; 3Saint Louis University Center for Transplant Research, St. Louis.

    Purpose: Dyslipidemia is a common comorbidity in patients on the transplant waitlist and post-transplant, and hyperlipidemia has been associated with more robust immune response, possibly…
  • 2016 American Transplant Congress

    Antibody-Mediated Rejection Can Be Assessed by Histology When DSA Is Unknown or Negative.

    J. Reeve,1 P. Halloran.2

    1Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; 2Department of Medicine, University of Alberta, Edmonton, AB, Canada.

    Diagnosis of antibody-mediated rejection (ABMR) in kidney transplants currently requires the presence of donor-specific antibody (DSA) and histologic lesions above somewhat arbitrary cutoffs. DSA is…
  • 2016 American Transplant Congress

    The Phenotypic Diversity of Late Silent Antibody-Mediated Rejection.

    F. Eskandary,1,2 J. Reeve,1,3 H. Regele,4 L. Hidalgo,1,3 D. Yoo,1 N. Kozakowski,4 K. Famulski,1 G. Böhmig,2 P. Halloran.1,5

    1Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada; 2Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria; 3Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; 4Department of Clinical Pathology, Medical University of Vienna, Vienna, Austria; 5Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada.

    Study purpose: ABMR is a driving force of long-term allograft loss in organ transplantation. The present study was designed to characterize the phenotypic diversity of…
  • 2016 American Transplant Congress

    Graft Survival in Sensitized and Non-Sensitized Patients: Role of the Combination of Donor-Specific Antibodies and Acute Rejection.

    P. Souza,1 A. Aguirre,1 G. Bezerra,2 H. Rodrigues,2 F. Agena,1 D. David,1 F. de Paula,1 E. David-Neto,1 M. Castro.1

    1Renal Transplant Service, Hospital das Clínicas de São Paulo, Sao Paulo, Brazil; 2Immunology Laboratory, Instituto do Coração (InCor), Sao Paulo, Brazil.

    Background: Sensitized (S) patients have higher risk for acute rejection (AR), especially ABMR. DSA is a risk fator for ABMR, however, its impact on AR…
  • 2016 American Transplant Congress

    A Retrospective Analysis of Rabbit Antithymocyte Globulin Dosing, MELD, Race, and Weight on Infection and Rejection Rates in Liver Transplantation.

    R. Imai, U. Wang.

    Department of Pharmacy, Stanford Health Care, Stanford, CA.

    INTRODUCTION: Rabbit antithymocyte globulin (rATG) use in liver transplantation is uncommon. At our center, induction therapy is comprised of rATG dosed at 1 – 2…
  • 2016 American Transplant Congress

    Durable Clinical and Immunologic Advantage of Living Donor Liver Transplantation (LDLT) in Children.

    E. Przybyszewski,1 S. Lobritto,1 M. Martinez,1 J. Vittorio,1 A. Fox,1 B. Samstein,2 T. Kato,1 A. Griesemer,1 J. Emond.1

    1Columbia University Medical Center, New York, NY; 2Weill Cornell Medical College, New York, NY.

    Purpose:Despite good results, only 10% of liver transplants in children in the US are from living donors. In addition to optimal timing and graft quality,…
  • 2016 American Transplant Congress

    Differential Regulation of the Microvascular Endothelial Cell Mediated Allogeneic CD4+ T Cell Response by Anti-HLA-DR and -DQ Alloantibodies in an Inflammatory Context.

    N. Mooney,1,2 A. Cross,1,2 J. Lion,1,2 A. Haziot,1,2 D. Glotz.1,2,3

    1INSERM UMRS 1160, Institut Universitaire d'Hématologie, Paris, France; 2Université-Paris-Diderot, Sorbonne Paris Cité, Paris, France; 3Service de Néphrologie et Transplantation, Hôpital Saint Louis, Paris, France.

    This study examines the basic mechanisms by which high levels of circulating HLA class II donor-specific-antibodies can contribute to microvasculature damage in chronic antibody mediated…
  • 2016 American Transplant Congress

    Kidney Transplantation in HIV Patients: Effect of Race on the Choice of Anti-Thymocyte Globulin Induction Immunosuppression.

    M. Casey, T. Aijaz, X. Wen, S. Rehman, A. Santos, E. Thomas, K. Andreoni, K. Womer.

    University of Florida, Gainesville, FL.

    Introduction: HIV positive status is a well-known risk factor for acute rejection (AR) in kidney transplant recipients (KTR). In the United States, the majority of…
  • 2016 American Transplant Congress

    Blockade of HLA Antibody-Triggered Classical Complement Activation by High-Affinity Humanized Monoclonal Anti-C1s Antibody TNT009 – Results of a First-in-Human Phase 1 Trial.

    J. Mühbacher,1 B. Jilma,2 M. Wahrmann,3 L. Marinova,3 F. Eskandary,3 J. Gilbert,4 S. Panicker,4 G. Böhmig.3

    1Department of Surgery, Medical University of Vienna, Vienna, Austria; 2Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; 3Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria; 4True North Therapeutics, Inc., South San Francisco, CA.

    Study purpose: Classical complement may play a key role in ABMR. A promising therapeutic approach could be complement inhibition at the level of key component…
  • 2016 American Transplant Congress

    Association of Ultrastructural Changes in Renal Allograft Biopsies with Antibody-Mediated Rejection (AMR) and Graft Outcomes.

    A. Haririan,1 M. Chaudhry,2 J. Papadimitriou,2 N. Costa,1 B. Thomas,1 M. Mavanur,1 R. Ugarte,1 C. Cangro,1 C. Drachenberg.2

    1Dept of Medicine, Unniversity of Maryland, Baltimore, MD; 2Dept of Pathology, University of Maryland, Baltimore, MD.

    The role of electron microscopy (EM) in diagnosis of AMR is not well-defined. We sought to examine the EM findings in 796 biopsies from 622…
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