ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2016 American Transplant Congress

    Clinical Significance of Non-HLA Antibodies in the Development of Microcirculation Inflammation in Allograft Tissue After Kidney Transplantation.

    J. Min,1,3 H. Lee,2,3 B. Chung,1,3 E.-J. Oh,2,3 C. Yang.1,3

    1Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; 2Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; 3Transplant Research Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

    The aim of our study is to determine the clinical significance of pre-transplant non-HLA antibodies, mainly those targeting the angiotenin II type I receptor (AT1R)…
  • 2016 American Transplant Congress

    Evaluation of the Toxicity Profile of Proteasome Inhibitor-Based Therapy for Antibody Mediated Rejection.

    A. Leino,1 A. Lichvar,1 B. Abu-Jawdeh,1 A. Govil,1 G. Mogilishetty,1 M. Cardi,2 J. Kremer,2 M. Cuffy,1 F. Paterno,1 R. Alloway,1 A. Shields,1,2 E. Woodle.1

    1U of Cinncinati, Cincinnati; 2The Christ Hospital, Cincinnati.

    Background: Experience with bortezomib (BTZ) antibody mediated rejection (AMR) therapy has progressively increased over the past few years. The BTZ toxicity profile in the transplant…
  • 2016 American Transplant Congress

    IFN-γ and Contact-Dependent Cytotoxicity Are Rate-Limiting for NK Cells in a Model of Antibody-Mediated Chronic Rejection.

    C. Lin,1 R. Plenter,1 R. Gill.2

    1Medicine, University of Colorado, Denver, Aurora, CO; 2Surgery, University of Colorado, Denver, Aurora, CO.

    BACKGROUND. Natural killer (NK) cells are key components of the innate immune that contribute to acute and chronic graft rejection. After engagement with antibody, NK…
  • 2016 American Transplant Congress

    Comparison of Efficacy and Safety of a 4-Month Post-Renal Transplant Dose Reduction of Tacrolimus.

    P. Gatault,1 N. Kamar,2 M. Buchler,1 C. Colosio,3 D. Bertrand,4 A. Durrbach,5 L. Albano,6 J. Rivalan,7 M. Essig,8 Y. Le Meur,9 N. Bouvier,10 B. Charpentier,5 E. Thervet,11 L. Rostaing,2 Y. Lebranchu.1

    1Service de Transplantation rénale, CHRU, Tours, France; 2Service de Transplantation Rénale, CHU, Toulouse, France; 3Service de Transplantation Rénale, CHU, Reims, France; 4Service Transplantation Rénale, CHU, Rouen, France; 5Service de Transplantation Rénale, APHP, Kremlin Bicêtre, France; 6Service de Transplantation Rénale, CHU, Nice, France; 7Service de Transplantation Rénale, CHU, Rennes, France; 8Service de Transplantation Rénale, CHU, Limoges, France; 9Service de Transplantation Rénale, CHU, Brest, France; 10Service de Transplantation Rénale, CHU, Caen, France; 11Service de Néphrologie, APHP, Centre Européen Georges Pompidou, Boulogne-Billancourt, France.

    Introduction. The aim of the study was to determine the efficacy and safety balance of 2 different doses of tacrolimus extended-release (TacER) in kidney transplant…
  • 2016 American Transplant Congress

    The Urine Common Rejection Module (uCRM) Is a Sentinal Assay for Graft Rejection.

    T. Sigdel,1 T. Tran,1 O. Bestard,2 F. Vincenti,1 M. Sarwal.1

    1Surgery, UCSF, San Francisco, CA; 2Nephrology, Bellevitage Hospital, Barcelona, Spain.

    Background: A common rejection module (CRM) consisting of 11 genes are expressed in solid organ transplant rejection in kidney, heart, liver and lung transplantation (Khatri,…
  • 2016 American Transplant Congress

    CMV-Accelerated Cardiac Allograft Rejection Is Associated with Dysregulation of Sphingolipid Metabolomics.

    J. Burg,1 T. Andoh,2 N. Haese,2 C. Kreklywich,2 K. Watters,3 T. Metz,3 S. Orloff,1 D. Streblow.2

    1Abdominal Organ Transplantation, OHSU, Portland, OR; 2VGTI, OHSU, Portland, OR; 3Biological Sciences Division, PNNL, Richland, WA.

    PurposeCytomegalovirus (CMV) infection accelerates transplant vascular sclerosis (TVS) and chronic rejection (CR) in solid organ transplants. Sphingolipid metabolism plays an immunomodulatory role in transplant rejection,…
  • 2016 American Transplant Congress

    Effect of Early Tacrolimus Trough Variability on Graft Outcomes in Lung Transplantation.

    K. Boyle, M. Moranville, P. Shah.

    The Johns Hopkins Hospital, Baltimore, MD.

    Background: Recent data suggests that variability in tacrolimus trough levels after lung transplant may be associated with poor long term graft outcomes. The purpose of…
  • 2016 American Transplant Congress

    Early Onset Acute Antibody Mediated Rejection (ABMR) Is More Common in Female Than in Male Recipients of a Living Unrelated Donor (LURD) Renal Transplant and Is Associated with the Presence of Preformed Donor Specific Antibodies (DSA).

    D. Soonawala,1 K. Groeneweg,1 F. van der Toorn,1 S. Heidt,2 D. Roelen,2 F. Claas,2 J. de Fijter.1

    1Nephrology, LUMC, Leiden, Netherlands; 2IHB, LUMC, Leiden, Netherlands.

    Introduction: Women who receive a renal graft from their male spouse have a higher risk of early onset acute ABMR. The aim of this study…
  • 2016 American Transplant Congress

    Detection of Endothelial Cell Specific Molecule-1 According to Allograft Status After Kidney Transplantation.

    J.-W. Seo, S.-Y. Kim, Y.-G. Kim, Y.-H. Jeong, Y.-H. Lee, J.-Y. Moon, T.-W. Lee, C.-G. Ihm, S.-H. Lee.

    Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

    To investigate urine ESM-1(endothelial cell specific molecule-1) as well as plasma ESM-1 level from renal allograft recipients, we show whether there is the difference of…
  • 2016 American Transplant Congress

    Elevation of Peripheral IL-6 in Kidney Transplant Recipients with Antibody Mediated Rejection.

    N. Wilson, A. Djamali, R. Redfield.

    University of Wisconsin, Madison.

    Background: Despite current therapy, antibody mediated rejection (AMR) remains a major cause of kidney allograft loss. IL-6 is a known survival factor of antibody secreting…
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