ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rat"

  • 2017 American Transplant Congress

    Tolerogenic Potential, Migratory Pathways, Engraftment and Long-Term Survival of Human Hematopoietic Chimeric Cells – A Novel Strategy to Induce Tolerance in Transplantation.

    M. Siemionow, E. Bryndza Tfaily, E. Szilagyi, J. Cwykiel, S. Uygur, M. Czerwinski.

    Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL

    Background: Cell-based therapies represent a new promising strategy for tolerance induction in transplantation. One of the methods for immune response modulation in solid organ and…
  • 2017 American Transplant Congress

    Decellularized Rat Liver Scaffolds Support Survival and Metabolic Function of Multilineage Allogenic Cells.

    W. Hassanein, A. Werdesheim, A. Cimeno, B. Buckingham, A. Khalifeh, M. Uluer, J. Harrison, D. Parsell, C. Drachenberg, R. Barth, J. LaMattina.

    University of Maryland School of Medcine, Baltimore, MD

    Background:Organ bioengineering has the potential to completely eliminate the donor organ shortage. Here, we examine the feasibility of a decellularized liver construct to support the…
  • 2017 American Transplant Congress

    Cell-Subset Diversity in Adipose Derived Regenerative Cells Used in Renal Ischemic Reperfusion Injury Treatment.

    R. Lathan,1 R. Ghita,1,2 D. Hillyard,1 P. Mark,1,2 M. Clancy.1,2

    1Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; 2School of Medicine, Dentistry and Nursing, Queen Elizabeth University Hospital, Glasgow, United Kingdom

    Studies in our novel hybrid model of transplantion/ischemic reperfusion injury (IRI) in rat has demonstrated significant improvement in kidney function post injection of adipose-derived regenerative…
  • 2016 American Transplant Congress

    ER Stress and Loss of GRP78 Expression Provides a Link Between Renal Ischemia/Reperfusion Injury and the Urinary Metabolome.

    C. van Kooten,1 T. Pacchiarotta,2 P. van der Pol,1 J. de Fijter,1 N. Schlagwein,1 D. van Gijlswijk,1 O. Mayboroda.2

    1Nephrology, Leiden University Medical Center, Leiden, Netherlands; 2Centre for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.

    Ischemia/reperfusion injury (IRI) profoundly impacts graft survival following kidney transplantation. Epithelial injury is one of the earliest histological alterations of IRI and is especially observed…
  • 2016 American Transplant Congress

    MicroRNA let-7i Regulates Dendritic Cells Maturation Targeting Interleukin-10 via JAK1-STAT3 Signal Pathway Subsequently Induces Prolonged Cardiac Allograft Survival in Rats.

    X. Jin,1 Y. Sun,2 X. Liu,2 J. Wang,1 S. Xu,1 L. Yao,1 Z. Zhao,3 L. Jiang,4 Q. Wu,5 J. Wu.2

    1Thoracic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China; 2Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; 3Pediatric Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China; 4Otorhinolaryngology, The First Affiliated Hospital of Harbin Medical University, Harbin, China; 5Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

    Background:Our previous study demonstrated that microRNA (MiR) let-7i could regulate dendritic cells (DCs) maturation and functional state via targeting SOCS1. In this study, we investigated…
  • 2016 American Transplant Congress

    Creation of a Small Animal Model of Ex-Vivo Normothermic Perfusion (EVNP) for Treatment of Kidney Ischemia-Reperfusion (I/R) Injury.

    Y. Smolin, I. Palma, C. Pivetti, S. Kabagambe, J. Woloszyn, Y. Chen, T. Boyer, I. Palma, J. Sageshima, C. Santhanakrishnan, R. Perez.

    Department of Surgery, UC Davis Medical Center, Sacramento, CA.

    Purpose: Recent studies have suggested that EVNP may be utilized to assess and repair marginal donor organs subjected to severe I/R injury. The lack of…
  • 2016 American Transplant Congress

    Short, Cool and Well Oxygenated – HOPE for DCD Kidneys.

    P. Kron, A. Schlegel, O. de Rougemont, C. Oberkofler, P.-A. Clavien, P. Dutkowski.

    University Hospital, Zurich, Switzerland.

    Background Organs from donors after cardiac death (DCD) suffer from severe loss of function requiring development of innovative methods of preservation. A novel perfusion approach,…
  • 2016 American Transplant Congress

    Mitochondrial Membrane Potential Correlates with Ischemic Injury and Kidney Graft Function in Rats.

    M. Chen, J. Huang, L. Qi, S. Kwon, R. Montgomery, Z. Sun.

    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

    BackgroundBoth short- and long-term outcomes of all organ transplants depend on the quality of the organ. Presently there is no completely reliable method to evaluate…
  • 2016 American Transplant Congress

    Improved Regeneration of the Remnant Liver After Extended Hepatectomy or Partial Liver Transplantation by Pharmacologic Mobilization of Endogenous Stem Cells in Rats.

    M. Chen, R. Zhai, L. Qi, A. Cameron, B. Philosophe, Z. Sun.

    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

    BackgroundRapid regeneration of the remnant liver after extended partial hepatectomy or reduced size liver transplantation is essential to prevent small-for-size syndrome (SFSS). We hypothesize that…
  • 2016 American Transplant Congress

    Decellularized Rat Liver Scaffolds Support Multilineage Xenogenic and Heterogenic Cell Growth.

    W. Hassanein, U. Dhru, J. Woodall, M. Uluer, A. Cimeno, D. Parsell, C. Rivera, S. Klepfer, C. Drachenberg, R. Barth, J. LaMattina.

    University of Maryland School of Medicine, Baltimore, MD.

    Background:Recent years have seen a proliferation of methods leading to successful organ decellularization. Nonetheless, the ability to reproducibly generate a robust recellularized construct remains challenging.…
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