Articles tagged "Rat"

2017 American Transplant Congress
The Novel Establishment of Neuroma in Continuity Animal Model Based on Buccal Nerve in Rats.
Y.-H. Hsieh,^1,2 C.-J. Wen,^1,3 C.-H. Lin,^1,2,3,4 F.-C. Wei,^1,2,3 Y.-C. Pei.^3,5
¹Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ³College of Medicine, Chang Gung University, Taoyuan, Taiwan; ⁴Division of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁵Department of Physical Medicine & Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Introduction: Peripheral nerve regeneration is a challenging and a rapid growing field. Its application is no longer restricted to trauma reconstruction but also in vascularized…
2017 American Transplant Congress
Biodistribution of Adipose Derived Regenerative Cells Administered via the Renal Artery in Novel Rat Transplant Model.
R. Ghita,^1,2 R. Lathan,² D. Hillyard,² P. Mark,^1,2 M. Clancy.^1,2
¹Glasgow Renal and Transplant Unit, Queen Elizabeth University Hospital Glasgow, Glasgow, United Kingdom; ²Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
Introduction:A novel rodent model of ischaemia- reperfusion injury (IRI) has shown significant improvement in renal function and histology after administration of adipose derived regenerative cells…
2017 American Transplant Congress
Lipid Catabolism Provides Alternative Energy Source and Compensates for Mitochondrial Dysfunction in Reperfused Rat Kidneys After Ischaemia.
H. Huang,^1,2 L. van Dullemen,³ M. Akhtar,¹ M. Lo Faro,^1,2 A. Dona,⁴ M. Kaisar,^1,2 H. Leuvenink,³ B. Kessler,² R. Ploeg.¹
¹Oxford Transplant Centre, NDS, University of Oxford, Oxford, United Kingdom; ²Target Discovery Institute, NDM, University of Oxford, Oxford, United Kingdom; ³Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; ⁴Department of Surgery and Cancer, Imperial College London, London, United Kingdom
Introduction: To reduce morbidity and mortality on the wait list for kidney transplantation, centres are required to use older and higher risk organs including unstable…
2016 American Transplant Congress
MicroRNA let-7i Regulates Dendritic Cells Maturation Targeting Interleukin-10 via JAK1-STAT3 Signal Pathway Subsequently Induces Prolonged Cardiac Allograft Survival in Rats.
X. Jin,¹ Y. Sun,² X. Liu,² J. Wang,¹ S. Xu,¹ L. Yao,¹ Z. Zhao,³ L. Jiang,⁴ Q. Wu,⁵ J. Wu.²
¹Thoracic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China; ²Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; ³Pediatric Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China; ⁴Otorhinolaryngology, The First Affiliated Hospital of Harbin Medical University, Harbin, China; ⁵Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Background:Our previous study demonstrated that microRNA (MiR) let-7i could regulate dendritic cells (DCs) maturation and functional state via targeting SOCS1. In this study, we investigated…
2016 American Transplant Congress
Creation of a Small Animal Model of Ex-Vivo Normothermic Perfusion (EVNP) for Treatment of Kidney Ischemia-Reperfusion (I/R) Injury.
Y. Smolin, I. Palma, C. Pivetti, S. Kabagambe, J. Woloszyn, Y. Chen, T. Boyer, I. Palma, J. Sageshima, C. Santhanakrishnan, R. Perez.
Department of Surgery, UC Davis Medical Center, Sacramento, CA.
Purpose: Recent studies have suggested that EVNP may be utilized to assess and repair marginal donor organs subjected to severe I/R injury. The lack of…
2016 American Transplant Congress
Short, Cool and Well Oxygenated – HOPE for DCD Kidneys.
P. Kron, A. Schlegel, O. de Rougemont, C. Oberkofler, P.-A. Clavien, P. Dutkowski.
University Hospital, Zurich, Switzerland.
Background Organs from donors after cardiac death (DCD) suffer from severe loss of function requiring development of innovative methods of preservation. A novel perfusion approach,…
2016 American Transplant Congress
Mitochondrial Membrane Potential Correlates with Ischemic Injury and Kidney Graft Function in Rats.
M. Chen, J. Huang, L. Qi, S. Kwon, R. Montgomery, Z. Sun.
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
BackgroundBoth short- and long-term outcomes of all organ transplants depend on the quality of the organ. Presently there is no completely reliable method to evaluate…
2016 American Transplant Congress
Improved Regeneration of the Remnant Liver After Extended Hepatectomy or Partial Liver Transplantation by Pharmacologic Mobilization of Endogenous Stem Cells in Rats.
M. Chen, R. Zhai, L. Qi, A. Cameron, B. Philosophe, Z. Sun.
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
BackgroundRapid regeneration of the remnant liver after extended partial hepatectomy or reduced size liver transplantation is essential to prevent small-for-size syndrome (SFSS). We hypothesize that…
2016 American Transplant Congress
Decellularized Rat Liver Scaffolds Support Multilineage Xenogenic and Heterogenic Cell Growth.
W. Hassanein, U. Dhru, J. Woodall, M. Uluer, A. Cimeno, D. Parsell, C. Rivera, S. Klepfer, C. Drachenberg, R. Barth, J. LaMattina.
University of Maryland School of Medicine, Baltimore, MD.
Background:Recent years have seen a proliferation of methods leading to successful organ decellularization. Nonetheless, the ability to reproducibly generate a robust recellularized construct remains challenging.…
2016 American Transplant Congress
A Novel Murine Orthotopic Forelimb Transplantation Model That Allows for Reliable Assessment of Post-Transplant Upper Extremity Function.
J. Budihardjo,¹ B. Kern,^1,2 S. Mermulla,¹ A. Quan,¹ C. Cadmi,¹ J. Lopez,¹ J. Park,¹ A. Hoke,¹ W. Lee,¹ S. Tuffaha,¹ G. Brandacher.¹
¹Plastic Surgery, Johns Hopkins Medical Institutions, Baltimore, MD; ²Transplant Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Background: Studies related to functional return for upper extremity transplantation have been limited by the lack of a functional VCA animal model. The rat hindlimb…