ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rat"

  • 2020 American Transplant Congress

    Stem Cell and Novel Neurotrophic Factors to Promote Functional Outcomes in Limb Transplantation

    S. K. Salgar, J. Weiss, C. Phillips, E. Malin, V. Gorantla, J. Harding

    Clinical Investigation, Madigan Army Medical Center, Tacoma, WA

    *Purpose: Recently, transplantation of hand and face has become a new clinical specialty. The objective of this study was to determine whether adult Mesenchymal Stem…
  • 2020 American Transplant Congress

    Renal Immunoproteasome Function: A Possible Cause for Macrophage Associated Organ Damage During Renal Transplantation?

    N. Parajuli, A. Khakurel

    University of Arkansas for Medical Sciences, Little Rock, AR

    *Purpose: A major hurdle in the field of renal transplantation is the shortage of suitable donor kidneys. Renal transplantation using living-donor organs perform better when…
  • 2020 American Transplant Congress

    Impact of Extracorporeal Photopheresis in a Full-Mismatch Kidney Transplant Rat Model

    J. Rovira1, G. J. Piñeiro2, M. Lazo-Rodriguez3, M. J. Ramirez-Bajo1, E. Banon-Maneus3, N. Hierro-Garcia3, P. Ventura-Aguiar2, J. Cid4, M. Lozano4, F. Diekmann2

    1Laboratori Experimental de Nefrologia i Trasplantament (LENIT), IDIBAPS, Barcelona, Spain, 2Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain, 3Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic per la Recerca Biomèdica (FCRB), Barcelona, Spain, 4Apheresis Unit, Department of Hemotherapy and Hemostasis, Hospital Clínic de Barcelona, Barcelona, Spain

    *Purpose: Extracorporeal photopheresis (ECP) is an immunomodulatory cell therapy based on the infusion of autologous cellular products exposed to ultraviolet light (UV), in the presence…
  • 2020 American Transplant Congress

    Development of a Novel Multidrug Combination to Defat Steatotic Rat Liver via Normothermic Machine Perfusion

    M. Xu1, F. Zhou1, O. Ahmed1, G. Upadhya1, J. Jia1, C. Lee1, J. Xing1, L. Ye1, S. Shim1, Z. Zhang1, K. Byrnes2, B. Wong1, J. Kim1, Y. Lin1, W. Chapman1

    1Surgery, Washington University, St. Louis, MO, 2Pathology and Immunology, Washington University, St. Louis, MO

    *Purpose: Hepatic steatosis is now the leading cause of liver discards in deceased donors. Previous studies (Yarmush et al., Y defatting) have successfully reduced the…
  • 2020 American Transplant Congress

    ANG-3777, A Hepatic Growth Factor Mimetic, Attenuates Mercuric Chloride-Induced Renal Dysfunction and Mortality in Rats

    P. Narayan, I. D. Goldberg

    Angion Biomedica, Uniondale, NY

    *Purpose: ANG-3777 is a small-molecule mimetic of hepatocyte growth factor (HGF). In vitro models have shown ANG-3777 to have protective effects in renal cell lines,…
  • 2019 American Transplant Congress

    Evaluation of New Baskent University Preservation Solution for Liver, Kidney and Intestine Graft during Cold Ischemia: Preliminary Experimental Animal Study

    M. Haberal1, M. Kirnap1, R. Erdem2, H. Ozdemir3, M. Lux2, D. Bacanli4

    1Transplantation, Baskent University, Ankara, Turkey, 2Pharmacology, Baskent University, Ankara, Turkey, 3Pathology, Baskent University, Ankara, Turkey, 4Experimental Laboratory, Baskent University, Ankara, Turkey

    *Purpose: Despite significant advances in organ transplantation, damage caused to organs due to long cold ischemia time and perfusion solutions remains a serious hurdle. The…
  • 2019 American Transplant Congress

    Cryopreservation Allows for Extended Graft Survival in a Rat Orthotopic Hind Limb Model

    S. A. Fidder1, B. Oh1, F. Messner1, G. Furtmueller1, K. Helke2, E. Greene3, Z. Chen3, L. Campbell3, G. Brandacher1, K. Brockbank3

    1Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 2Department Of Comparative Medicine, Medical University of South Carolina, Charleston, SC, 3Tissue Testing Technologies LLC, Charleston, SC

    *Purpose: Vascularized composite allotransplantation (VCA) is a viable reconstructive option for devastating tissue defects. The growth of the field is restrained by the limited ischemia…
  • 2019 American Transplant Congress

    Immunosuppression Increases Regenerative Potential of Adult Rat Cardiac Progenitor Cells in Allogeneic Rat Myocardial Infarction Model

    M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, M. Y. Arfat, C. Ambastha, D. Morales, F. Xuebin, G. J. Bittle, D. Li, S. Kaushal

    Department of Surgery, University of Maryland, Baltimore 21201, MD

    *Purpose: Cardiac progenitor cells (CPCs, c-kit+) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, immune response to…
  • 2019 American Transplant Congress

    Stem Cell and Granulocyte- Colony Stimulating Factor Therapies to Improve Functional Outcomes in Limb Transplantation

    J. Weiss1, C. Phillips1, E. Malin1, V. Gorantla2, S. K. Salgar3

    1Surgery, Madigan Army Medical Center, Tacoma, WA, 2Surgery, Wake Forest University, Salem, NC, 3Clinical Investigation, Madigan Army Medical Center, Tacoma, WA

    *Purpose: Although, over 200 clinical Vascularized Composite Allotransplantation (VCA) such as hands, legs, and face have been performed worldwide, still there are many challenges such…
  • 2019 American Transplant Congress

    CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury

    C. Akateh1, B. F. Reader1, Y. Lee1, J. Kim1, K. Maynard1, K. W. Washburn1, J. L. Zweier2, B. A. Whitson1, S. M. Black1

    1Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, 2The Ohio State University Wexner Medical Center, Columbus, OH

    *Purpose: Ischemia/reperfusion injury (IRI) is a major source of injury during many surgical procedures on the liver, and severe IRI can lead to post-hepatectomy liver…
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