ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rat"

  • 2021 American Transplant Congress

    Platelets Stimulate Liver Regeneration After Partial Liver Transplantation

    K. Takahashi, C. Liang, K. Furuya, T. Oda

    GI and HBP Surgery, University of Tsukuba, Tsukuba, Japan

    *Purpose: Living donor liver transplant (LDLT) can sometimes be associated with impaired regeneration and severe ischemia/reperfusion (I/R) injury in the liver graft, resulting in small-for-size…
  • 2021 American Transplant Congress

    Galectin-3 Blockade Can Decrease Reperfusion Injury in Response to Ischemia in a Rat Hind Limb Transplant Model

    Z. Wang1, Y. Wang1, D. Yoeli1, B. Li1, A. Su1, D. Mathes1, K. Washington1, E. Farkash2, C. A. Huang1

    1University of Colorado, Aurora, CO, 2University of Michigan, Ann Arbor, Ann Arbor, MI

    *Purpose: Vascularized composite allograft (VCA) transplant is technically feasible and results in successful clinical outcomes. However, skin and muscle containing VCA is highly susceptible to…
  • 2020 American Transplant Congress

    Impact of Extracorporeal Photopheresis in a Full-Mismatch Kidney Transplant Rat Model

    J. Rovira1, G. J. Piñeiro2, M. Lazo-Rodriguez3, M. J. Ramirez-Bajo1, E. Banon-Maneus3, N. Hierro-Garcia3, P. Ventura-Aguiar2, J. Cid4, M. Lozano4, F. Diekmann2

    1Laboratori Experimental de Nefrologia i Trasplantament (LENIT), IDIBAPS, Barcelona, Spain, 2Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain, 3Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic per la Recerca Biomèdica (FCRB), Barcelona, Spain, 4Apheresis Unit, Department of Hemotherapy and Hemostasis, Hospital Clínic de Barcelona, Barcelona, Spain

    *Purpose: Extracorporeal photopheresis (ECP) is an immunomodulatory cell therapy based on the infusion of autologous cellular products exposed to ultraviolet light (UV), in the presence…
  • 2020 American Transplant Congress

    Development of a Novel Multidrug Combination to Defat Steatotic Rat Liver via Normothermic Machine Perfusion

    M. Xu1, F. Zhou1, O. Ahmed1, G. Upadhya1, J. Jia1, C. Lee1, J. Xing1, L. Ye1, S. Shim1, Z. Zhang1, K. Byrnes2, B. Wong1, J. Kim1, Y. Lin1, W. Chapman1

    1Surgery, Washington University, St. Louis, MO, 2Pathology and Immunology, Washington University, St. Louis, MO

    *Purpose: Hepatic steatosis is now the leading cause of liver discards in deceased donors. Previous studies (Yarmush et al., Y defatting) have successfully reduced the…
  • 2020 American Transplant Congress

    ANG-3777, A Hepatic Growth Factor Mimetic, Attenuates Mercuric Chloride-Induced Renal Dysfunction and Mortality in Rats

    P. Narayan, I. D. Goldberg

    Angion Biomedica, Uniondale, NY

    *Purpose: ANG-3777 is a small-molecule mimetic of hepatocyte growth factor (HGF). In vitro models have shown ANG-3777 to have protective effects in renal cell lines,…
  • 2020 American Transplant Congress

    Cervical Total Arterial Anastomosis Mouse-to-Rat Heterotopic Heart Xenotransplantation

    A. Ren, Z. Li, X. Zhang, R. Deng, Y. Ma

    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    *Purpose: Xenotransplantation is an effective way to solve the problem of donor shortage. However, clinical use of xenotransplantation is currently limited due to immunological challenges.…
  • 2020 American Transplant Congress

    Metformin Improves Biomarkers of Calcineurin Inhibitor Related Nephrotoxicity

    M. R. Fernando, K. Taylor, S. Herath, A. Au, J. Erlich, Z. Endre

    Department of Nephrology, Prince of Wales Hospital, Randwick, Australia

    *Purpose: Calcineurin Inhibitors (CNIs) prevent transplant rejection but cause significant nephrotoxicity. Biomarkers of CNI nephrotoxicity could help drug dosing and improve long-term graft outcomes. As…
  • 2020 American Transplant Congress

    Two Novel Methods to Establish Rat Kidney Transplantation Model

    M. Zheng, Z. Gui, Z. Wang, J. Wei, X. Ju, R. Tan, M. Gu

    Jiangsu Province Hospital, Nanjing, China

    *Purpose: Rat kidney transplantation model is a standard animal model for the anti-rejection research of kidney transplantation. However, the current methods of the model require…
  • 2020 American Transplant Congress

    Oral Administration of Nano-Sized Silicon Particles Regulates Gene Expression Related to Oxidative Stress and Attenuates Rat Renal Ischemia Reperfusion Injury

    M. Kawamura1, R. Imamura1, Y. Kobayashi2, A. Taniguchi1, S. Nakazawa1, T. Kato1, T. Abe1, H. Kobayashi2, N. Nonomura1

    1Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, 2The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan

    *Purpose: Organ ischemia reperfusion injury (IRI) is unavoidable in kidney transplantation and induces reactive oxygen species and causes organ damage. Although the effectiveness of hydrogen…
  • 2020 American Transplant Congress

    Rat Hind Limb Transplant Model to Assess Vascularized Composite Allograft (VCA) Inflammation and Ischemia Reperfusion Injury

    Z. Wang1, A. B. Harrant1, Y. Wang1, K. Washington1, E. Farkash2, C. A. Huang1

    1Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, 2Pathology, University of Michigan, Ann Arbor, MI

    *Purpose: Vascularized composite allografts are potential surgical solutions for patients with traumatic or disfiguring injuries but are highly immunogenic and require elevated levels of immunosuppression.…
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