Articles tagged "Rat"

2021 American Transplant Congress
Galectin-3 Blockade Can Decrease Reperfusion Injury in Response to Ischemia in a Rat Hind Limb Transplant Model
Z. Wang¹, Y. Wang¹, D. Yoeli¹, B. Li¹, A. Su¹, D. Mathes¹, K. Washington¹, E. Farkash², C. A. Huang¹
¹University of Colorado, Aurora, CO, ²University of Michigan, Ann Arbor, Ann Arbor, MI
*Purpose: Vascularized composite allograft (VCA) transplant is technically feasible and results in successful clinical outcomes. However, skin and muscle containing VCA is highly susceptible to…
2021 American Transplant Congress
Stem Cell and Novel Neurotrophic Factors to Promote Functional Outcomes in Limb Transplantation
S. K. Salgar¹, J. Weiss², C. Phillips², E. Malin², V. Gorantla³, J. Harding⁴
¹Clinical Investigation, United States Army, Tacoma, WA, ²Clinical Investigation, Madigan Army Medical Center, Tacoma, WA, ³Surgery, Wake Forest University, Winston-Salem, NC, ⁴Neuroscience, Washington State Universisty, Pullman, WA
*Purpose: Recently, transplantation of hand and face has become a new clinical specialty. The objective of this study was to determine whether adult Mesenchymal Stem…
2020 American Transplant Congress
Cervical Total Arterial Anastomosis Mouse-to-Rat Heterotopic Heart Xenotransplantation
A. Ren, Z. Li, X. Zhang, R. Deng, Y. Ma
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Xenotransplantation is an effective way to solve the problem of donor shortage. However, clinical use of xenotransplantation is currently limited due to immunological challenges.…
2020 American Transplant Congress
Metformin Improves Biomarkers of Calcineurin Inhibitor Related Nephrotoxicity
M. R. Fernando, K. Taylor, S. Herath, A. Au, J. Erlich, Z. Endre
Department of Nephrology, Prince of Wales Hospital, Randwick, Australia
*Purpose: Calcineurin Inhibitors (CNIs) prevent transplant rejection but cause significant nephrotoxicity. Biomarkers of CNI nephrotoxicity could help drug dosing and improve long-term graft outcomes. As…
2020 American Transplant Congress
Two Novel Methods to Establish Rat Kidney Transplantation Model
M. Zheng, Z. Gui, Z. Wang, J. Wei, X. Ju, R. Tan, M. Gu
Jiangsu Province Hospital, Nanjing, China
*Purpose: Rat kidney transplantation model is a standard animal model for the anti-rejection research of kidney transplantation. However, the current methods of the model require…
2020 American Transplant Congress
Oral Administration of Nano-Sized Silicon Particles Regulates Gene Expression Related to Oxidative Stress and Attenuates Rat Renal Ischemia Reperfusion Injury
M. Kawamura¹, R. Imamura¹, Y. Kobayashi², A. Taniguchi¹, S. Nakazawa¹, T. Kato¹, T. Abe¹, H. Kobayashi², N. Nonomura¹
¹Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, ²The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan
*Purpose: Organ ischemia reperfusion injury (IRI) is unavoidable in kidney transplantation and induces reactive oxygen species and causes organ damage. Although the effectiveness of hydrogen…
2020 American Transplant Congress
Rat Hind Limb Transplant Model to Assess Vascularized Composite Allograft (VCA) Inflammation and Ischemia Reperfusion Injury
Z. Wang¹, A. B. Harrant¹, Y. Wang¹, K. Washington¹, E. Farkash², C. A. Huang¹
¹Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, ²Pathology, University of Michigan, Ann Arbor, MI
*Purpose: Vascularized composite allografts are potential surgical solutions for patients with traumatic or disfiguring injuries but are highly immunogenic and require elevated levels of immunosuppression.…
2020 American Transplant Congress
ANG-3777, A Hepatic Growth Factor Mimetic, Attenuates Post-Transplant Renal Dysfunction in Rats
P. Narayan, I. D. Goldberg
Angion Biomedica, Uniondale, NY
*Purpose: ANG-3777, a small-molecule mimetic of hepatocyte growth factor (HGF), has the potential to exert antifibrotic and nephroprotective effects. A rat model of renal transplantation…
2020 American Transplant Congress
ANG-3777 Treatment Attenuates Ischemia-Reperfusion-Induced Renal Injury in Rat and Dog Models
P. Narayan¹, M. Mangino², I. D. Goldberg¹
¹Angion Biomedica, Uniondale, NY, ²Virginia Commonwealth University, Richmond, VA
*Purpose: The effect of ANG-3777, a small-molecule mimetic of hepatocyte growth factor, was evaluated on reducing ischemia-reperfusion-induced renal injury and mortality in rats and dogs…
2020 American Transplant Congress
In Vivo Phosphorylation of C-MET by ANG-3777, A Hepatocyte Growth Factor Mimetic
L. Paka, I. D. Goldberg
Angion Biomedica, Uniondale, NY
*Purpose: : The biological effects of hepatocyte growth factor/scatter factor (HGF) and its mimetics are mediated by a signal cascade initiated by binding of HGF…