ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rat"

  • 2021 American Transplant Congress

    Platelets Stimulate Liver Regeneration After Partial Liver Transplantation

    K. Takahashi, C. Liang, K. Furuya, T. Oda

    GI and HBP Surgery, University of Tsukuba, Tsukuba, Japan

    *Purpose: Living donor liver transplant (LDLT) can sometimes be associated with impaired regeneration and severe ischemia/reperfusion (I/R) injury in the liver graft, resulting in small-for-size…
  • 2021 American Transplant Congress

    Galectin-3 Blockade Can Decrease Reperfusion Injury in Response to Ischemia in a Rat Hind Limb Transplant Model

    Z. Wang1, Y. Wang1, D. Yoeli1, B. Li1, A. Su1, D. Mathes1, K. Washington1, E. Farkash2, C. A. Huang1

    1University of Colorado, Aurora, CO, 2University of Michigan, Ann Arbor, Ann Arbor, MI

    *Purpose: Vascularized composite allograft (VCA) transplant is technically feasible and results in successful clinical outcomes. However, skin and muscle containing VCA is highly susceptible to…
  • 2020 American Transplant Congress

    Two Novel Methods to Establish Rat Kidney Transplantation Model

    M. Zheng, Z. Gui, Z. Wang, J. Wei, X. Ju, R. Tan, M. Gu

    Jiangsu Province Hospital, Nanjing, China

    *Purpose: Rat kidney transplantation model is a standard animal model for the anti-rejection research of kidney transplantation. However, the current methods of the model require…
  • 2020 American Transplant Congress

    Oral Administration of Nano-Sized Silicon Particles Regulates Gene Expression Related to Oxidative Stress and Attenuates Rat Renal Ischemia Reperfusion Injury

    M. Kawamura1, R. Imamura1, Y. Kobayashi2, A. Taniguchi1, S. Nakazawa1, T. Kato1, T. Abe1, H. Kobayashi2, N. Nonomura1

    1Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, 2The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan

    *Purpose: Organ ischemia reperfusion injury (IRI) is unavoidable in kidney transplantation and induces reactive oxygen species and causes organ damage. Although the effectiveness of hydrogen…
  • 2020 American Transplant Congress

    Rat Hind Limb Transplant Model to Assess Vascularized Composite Allograft (VCA) Inflammation and Ischemia Reperfusion Injury

    Z. Wang1, A. B. Harrant1, Y. Wang1, K. Washington1, E. Farkash2, C. A. Huang1

    1Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, 2Pathology, University of Michigan, Ann Arbor, MI

    *Purpose: Vascularized composite allografts are potential surgical solutions for patients with traumatic or disfiguring injuries but are highly immunogenic and require elevated levels of immunosuppression.…
  • 2020 American Transplant Congress

    ANG-3777, A Hepatic Growth Factor Mimetic, Attenuates Post-Transplant Renal Dysfunction in Rats

    P. Narayan, I. D. Goldberg

    Angion Biomedica, Uniondale, NY

    *Purpose: ANG-3777, a small-molecule mimetic of hepatocyte growth factor (HGF), has the potential to exert antifibrotic and nephroprotective effects. A rat model of renal transplantation…
  • 2020 American Transplant Congress

    ANG-3777 Treatment Attenuates Ischemia-Reperfusion-Induced Renal Injury in Rat and Dog Models

    P. Narayan1, M. Mangino2, I. D. Goldberg1

    1Angion Biomedica, Uniondale, NY, 2Virginia Commonwealth University, Richmond, VA

    *Purpose: The effect of ANG-3777, a small-molecule mimetic of hepatocyte growth factor, was evaluated on reducing ischemia-reperfusion-induced renal injury and mortality in rats and dogs…
  • 2020 American Transplant Congress

    In Vivo Phosphorylation of C-MET by ANG-3777, A Hepatocyte Growth Factor Mimetic

    L. Paka, I. D. Goldberg

    Angion Biomedica, Uniondale, NY

    *Purpose: : The biological effects of hepatocyte growth factor/scatter factor (HGF) and its mimetics are mediated by a signal cascade initiated by binding of HGF…
  • 2020 American Transplant Congress

    Stem Cell and Novel Neurotrophic Factors to Promote Functional Outcomes in Limb Transplantation

    S. K. Salgar, J. Weiss, C. Phillips, E. Malin, V. Gorantla, J. Harding

    Clinical Investigation, Madigan Army Medical Center, Tacoma, WA

    *Purpose: Recently, transplantation of hand and face has become a new clinical specialty. The objective of this study was to determine whether adult Mesenchymal Stem…
  • 2020 American Transplant Congress

    Renal Immunoproteasome Function: A Possible Cause for Macrophage Associated Organ Damage During Renal Transplantation?

    N. Parajuli, A. Khakurel

    University of Arkansas for Medical Sciences, Little Rock, AR

    *Purpose: A major hurdle in the field of renal transplantation is the shortage of suitable donor kidneys. Renal transplantation using living-donor organs perform better when…
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