ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Primates"

  • 2022 American Transplant Congress

    The Renin Angiotensin System (RAS) After Pig-to-Baboon Kidney Transplantation

    C. Hansen-Estruch1, M. H. Bikhet1, M. Javed1, D. Ayares2, A. Katsurada3, R. Satou3, W. Shao3, D. K. Cooper1, L. G. Navar3, E. Judd4

    1Surgery, University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA, 3Department of Physiology and Hypertension and Renal Center, Tulane University, New Orleans, LA, 4Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

    *Purpose: Relatively long-term survival after life-supporting pig-to-baboon kidney transplantation has been achieved. However, there are documented episodes of hypovolemia during the post-transplant period from an…
  • 2022 American Transplant Congress

    Rhesus-Primatized Mouse Model Generated Using Transgenic Immunodeficient Mice

    C. Little1, W. J. Haynes1, L. Huang1, C. Daffada1, K. B. Wolfe2, E. Perrin2, J. A. Simpson1, J. A. Kropp Schmidt2, H. M. Hinkle2, L. T. Keding2, R. T. Behrens2, D. T. Evans2, D. Kaufman1, J. A. Thomson2, T. G. Golos2, M. Brown1

    1Surgery, University of Wisconsin, Madison, WI, 2University of Wisconsin, Madison, WI

    *Purpose: To develop a translational primatized mouse model, akin to humanized mice, that allows for high-throughput in vivo experimentation to augment non-human primate pre-clinical studies.*Methods:…
  • 2022 American Transplant Congress

    Belatacept Augments Mixed Chimerism in a Novel Nonhuman Primate Kidney Transplant Tolerance Induction Protocol

    S. C. Kim, C. J. Little, J. H. Fechner, P. J. Chlebeck, J. Post, A. D'Alessandro, D. B. Kaufman

    University of Wisconsin, Madison, WI

    *Purpose: A novel protocol of antilymphocyte globulin (ATG), tomotherapy-based total lymphoid irradiation (TomoTLI), and adoptive cellular transfer was developed in a preclinical model of MHC-mismatched…
  • 2022 American Transplant Congress

    PD-1 Expression on CD8+ T Cells Contributes to the Establishment of Mixed Chimerism-Based Operational Tolerance

    C. J. Little, S. C. Kim, J. Fechner, J. Post, M. Winslow, D. B. Kaufman

    Surgery, University of Wisconsin, Madison, WI

    *Purpose: PD-1 is a T cell co-inhibitory molecule involved in T cell exhaustion and antigen specific hypo-reactivity. Given the role of PD-1 signaling in the…
  • 2022 American Transplant Congress

    Successful Use of Anti-IL-6R Therapy to Achieve Cardiac Allograft Tolerance in Non-Human Primates

    C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, A. Dehnadi, T. Costa, M. Momodu, J. A. Morrissette, D. Muldoon, I. M. Hanekamp, J. S. Allan, G. Benichou, J. C. Madsen

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: In contrast to kidney allografts, attempts to achieve tolerance of isolated cardiac allografts in non-human primates (NHPs) using a mixed chimerism strategy have been…
  • 2022 American Transplant Congress

    Triple-Knockout Pig Red Blood Cells as Potential Sources for Blood Transfusion in Alloimmunized Patients with Sickle Cell Disease

    T. Yamamoto1, M. H. Bikhet2, H. Q. Nguyen2, Y. Cui2, M. Javed2, S. S. Raza2, D. Ayares3, H. Iwase2, H. Hara2, D. K. Cooper1

    1Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, 3Revivicor, Blacksburg, VA

    *Purpose: Blood transfusion remains important in the treatment of patients with sickle cell disease (SCD). However, alloimmunization after multiple blood transfusions is associated with patient…
  • 2022 American Transplant Congress

    A Model of Idiopathic Pneumonia Syndrome in Rhesus Macaques

    R. S. Bermea1, K. Ingersoll2, L. P. Hariri3, M. Warren2, L. Kean2, V. Tkachev2

    1Pulmonary & Critical Care Medicine, Massachusetts General Hospital, Boston, MA, 2Hematology/Oncology, Boston Children's Hospital, Boston, MA, 3Pathology, Massachusetts General Hospital, Boston, MA

    *Purpose: To create a model of idiopathic pneumonia syndrome (IPS), a deadly complication of hematopoietic stem cell transplantation (HSCT) in Rhesus macaques (RM).*Methods: RM were…
  • 2021 American Transplant Congress

    Initial Experience with Growth Hormone Receptor Knockout in Pig-to-Baboon Kidney Transplantation: Effect on Ureteric Viability and Kidney Growth

    C. Hansen-Estruch1, H. Iwase1, A. Jagdale1, T. Yamamoto1, M. H. Bikhet1, J. Foote2, H. Hara1, D. Anderson1, P. Porrett1, D. Eckhoff1, D. Ayares3, W. Eyestone3, J. Locke1, D. K. Cooper1

    1Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, 2Department of Microbiology and Animal Resources Program, University of Alabama at Birmingham, Birmingham, AL, 3Revivicor, Blacksburg, VA

    *Purpose: The purpose of this study was to report outcomes of pig-to-baboon renal transplants using a novel growth hormone receptor knockout (GHRKO) organ-source pig created…
  • 2021 American Transplant Congress

    Anti-CD8 Immuno-PET for Non-invasive Tracking of Early Graft Rejection in a Non-human Primate Kidney Transplant Model

    K. Bruestle1, R. Tavare2, F. Fredriksson1, E. Duggan1, F. Huang1, B. Bhola1, J. Giurleo2, R. Foster2, P. Krueger2, M. Dobosz2, D. Ekanayake-Alper1, H. Sakai1, B. Piegari1, J. Castrillion1, S. M. Coley1, O. Harari2, A. Mintz1, D. Ma2, A. Griesemer1

    1Columbia University Medical Center, New York City, NY, 2Regeneron Pharmaceuticals, Inc, New York City, NY

    *Purpose: Infiltration of CD8 T cells into solid organ grafts is an early sign of rejection. REGN5054 is a fully human monoclonal antibody that binds…
  • 2021 American Transplant Congress

    Short-term Therapy with Anti-icam-1 Monoclonal Antibody Induced Long-term Liver Allograft Survival in Non-human Primates

    S. Hong1, D. Han2, S. Lee2, J. Kim3, E. Hwang3, H. Kim4, J. Lee5, K. Hong1, E. Han1, J. Cho1, J. Lee1, Y. Choi1, K. Lee1, N. Yi1, J. Yang1, K. Suh1

    1Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of, 2Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of, 3Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea, Republic of, 4Pathology, Seoul National University College of Medicine, Seoul, Korea, Republic of, 5Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of

    *Purpose: Tolerance induction remains challenging following liver transplantation and the long-term use of immunosuppressants, especially calcineurin inhibitors, leads to serious complications. We aimed to test…
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