ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Primates"

  • 2020 American Transplant Congress

    Transient Cd4+ T Cell and Cd20+ B Cell Depletion Leads to Prolonged Pig-To-Primate Kidney Xenograft Survival

    B. P. Lovasik1, A. J. Matar1, D. A. Faber1, D. V. Mathews1, C. Breeden1, S. C. Kim1, A. J. Tector2, A. B. Adams1

    1Emory University School of Medicine, Atlanta, GA, 2University of Miami, Miami, FL

    *Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacle to clinical application of pig organ xenografts. The aim of this study…
  • 2020 American Transplant Congress

    Early Post-Transplant Infusion of Ex Vivo-Expanded Autologous Polyclonal Regulatory T Cells (Treg) Prolongs Kidney Allograft Survival in Non-Lymphodepleted, CTLA4Ig-Treated Rhesus Monkeys

    K. Sasaki, Y. Wang, R. Nakano, L. Lu, J. Hughes, V. Vujevich, A. J. Ganoza, M. Wijkstrom, A. Humar, A. W. Thomson, M. B. Ezzelarab

    Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA

    *Purpose: Rodent studies have demonstrated the utility of regulatory T cell (Treg) infusion for the promotion of tolerance to organ allografts. Here, we evaluated the…
  • 2020 American Transplant Congress

    Long-term Functional Survival of Human Stem Cell-Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression

    M. C. Poznansky1, D. Alagpulinsa1, J. Lei2, R. Pop3, D. Sobell4, M. Chapin1, S. Collins3, A. Veres3, H. Deng2, D. Melton3, J. Markmann2

    1Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown Navy Yard, MA, 2Transplant Surgery, Massachusetts General Hospital, Boston, MA, 3Harvard Stem Cell Institute, Harvard University, Cambridge, MA, 4Vaccine and Immunotherapy Center, Massachusetts General Hospital, Boston, MA

    *Purpose: Human pluripotent stem cell-derived islet-like cells (SC-islets) represent a practical source for beta-cell replacement to achieve a functional cure for type 1 diabetes. Long-term…
  • 2020 American Transplant Congress

    Donor Mesenchymal Stem Cells in Combination with Co-Stimulation Blockade Prolong Allograft Survival

    A. J. Matar, B. P. Lovasik, S. C. Kim, C. A. Breeden, D. A. Faber, D. V. Mathews, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams

    Surgery and Transplantation, Emory University, Atlanta, GA

    *Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy and potential alternative to calcineurin inhibitors in solid organ transplantation. Despite recent advancements, CoB…
  • 2020 American Transplant Congress

    Peak DSA Levels Pre-Transplant but Not at Transplant Predict Graft Survival

    A. Y. Choi1, D. Olaso1, T. Risoli Jr2, M. Kuchibhatla2, Z. Fitch3, R. Schmitz3, P. M. Schroder3, A. Jackson3, M. Manook3, J. Yoon3, A. B. Farris4, J. Kwun3, S. J. Knechtle3

    1Duke University School of Medicine, Durham, NC, 2Duke Biostatistics, Epidemiology, and Research Design Core, Duke University, Durham, NC, 3Department of Surgery, Duke University Medical Center, Durham, NC, 4Department of Pathology, Emory University Hospital, Atlanta, GA

    *Purpose: Immunization to major histocompatibility complex (MHC) antigens is a barrier in kidney transplantation (KTx) due to higher risk of antibody-mediated rejection (AMR) and graft…
  • 2020 American Transplant Congress

    IL-6 Receptor Blockade But Not IL-2 Treatment Contributes to Long-Term NHP Cardiac Allograft Survival in Transient Mixed Chimeras

    K. Ahrens1, J. M. O1, W. Sommer2, J. Morrissette1, D. Becerra1, P. M. Patel1, T. Costa1, A. Dehnadi1, I. M. Hanekamp1, J. S. Allan3, G. Benichou1, J. C. Madsen4

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, 3Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, 4Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Long-term tolerance of cardiac allografts has been achieved in non-human primates (NHPs) using a mixed chimerism protocol and by co-transplanting a kidney from the…
  • 2020 American Transplant Congress

    Old World Monkeys Are Not Ideal Transplantation Models for Testing CMAHKO (TKO or GTKO/CMAHKO) Pig Kidneys

    T. Yamamoto1, H. Iwase1, D. Patel1, A. Jagdale1, J. Foote1, D. Ayares2, D. Anderson1, D. E. Eckhoff1, D. K. Cooper1, H. Hara1

    1University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA

    *Purpose: Triple-knockout (TKO) pigs are likely to be an optimal source of organs for transplantation into human recipients, many of whom do not have natural…
  • 2020 American Transplant Congress

    Splenectomy Impedes B Cell Infiltration Associated with Rejection of Neonatal Porcine Islet Xenografts

    Z. W. Fitch, M. Song, R. Schmitz, F. Leopardi, M. Ribeiro, A. Miller, G. Devi, B. Collins, X. Luo, A. D. Kirk

    Duke University, Durham, NC

    *Purpose: Xenotransplantation has historically been frustrated by antibody-mediated rejection. Splenectomy has shown efficacy in mediating humoral immunity. We hypothesized that adding splenectomy to a clinically…
  • 2020 American Transplant Congress

    Expression of Multiple Human Complement Regulatory Proteins Results in Prolonged Heterotopic Xenoheart Survival in an NHP Model

    K. Ahrens1, J. M. O1, W. Sommer2, D. Becerra1, P. M. Patel1, A. Dehnadi1, Y. Kan3, J. Layer3, J. Morrissette1, T. Costa1, I. M. Hanekamp1, J. S. Allan4, M. Youd3, R. N. Pierson5, W. Qin3, L. Burdorf5, A. M. Azimzadeh1, W. Westlin3, L. Yang3, J. C. Madsen5

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, 3eGenesis Inc., Cambridge, MA, 4Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, 5Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Advances in genome engineering technology allow for multiplex genetic modifications in pigs designed to address immunologic and coagulation incompatibilities in order to facilitate xenotransplantation.…
  • 2020 American Transplant Congress

    Pig-To-Baboon Liver Xenotransplantation Utilizing Genetically Modified Swine

    D. Detelich1, C. G. Rickert1, T. M. Coe1, S. Kimura1, I. Rosales1, H. Deng1, H. Yeh1, W. Qin2, Y. Kan2, J. Layer2, M. Youd2, W. Westlin2, L. Yang2, J. F. Markmann1

    1Massachusetts General Hospital, Boston, MA, 2eGenesis, Cambridge, MA

    *Purpose: Pig-to-baboon liver xenotransplant (LXT) continues with significant hurdles, including thrombocytopenia, coagulation dysregulation and rejection with the longest reported survival of 29 days utilizing a…
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