ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Primates"

  • 2022 American Transplant Congress

    The Renin Angiotensin System (RAS) After Pig-to-Baboon Kidney Transplantation

    C. Hansen-Estruch1, M. H. Bikhet1, M. Javed1, D. Ayares2, A. Katsurada3, R. Satou3, W. Shao3, D. K. Cooper1, L. G. Navar3, E. Judd4

    1Surgery, University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA, 3Department of Physiology and Hypertension and Renal Center, Tulane University, New Orleans, LA, 4Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

    *Purpose: Relatively long-term survival after life-supporting pig-to-baboon kidney transplantation has been achieved. However, there are documented episodes of hypovolemia during the post-transplant period from an…
  • 2022 American Transplant Congress

    Rhesus-Primatized Mouse Model Generated Using Transgenic Immunodeficient Mice

    C. Little1, W. J. Haynes1, L. Huang1, C. Daffada1, K. B. Wolfe2, E. Perrin2, J. A. Simpson1, J. A. Kropp Schmidt2, H. M. Hinkle2, L. T. Keding2, R. T. Behrens2, D. T. Evans2, D. Kaufman1, J. A. Thomson2, T. G. Golos2, M. Brown1

    1Surgery, University of Wisconsin, Madison, WI, 2University of Wisconsin, Madison, WI

    *Purpose: To develop a translational primatized mouse model, akin to humanized mice, that allows for high-throughput in vivo experimentation to augment non-human primate pre-clinical studies.*Methods:…
  • 2022 American Transplant Congress

    Belatacept Augments Mixed Chimerism in a Novel Nonhuman Primate Kidney Transplant Tolerance Induction Protocol

    S. C. Kim, C. J. Little, J. H. Fechner, P. J. Chlebeck, J. Post, A. D'Alessandro, D. B. Kaufman

    University of Wisconsin, Madison, WI

    *Purpose: A novel protocol of antilymphocyte globulin (ATG), tomotherapy-based total lymphoid irradiation (TomoTLI), and adoptive cellular transfer was developed in a preclinical model of MHC-mismatched…
  • 2022 American Transplant Congress

    PD-1 Expression on CD8+ T Cells Contributes to the Establishment of Mixed Chimerism-Based Operational Tolerance

    C. J. Little, S. C. Kim, J. Fechner, J. Post, M. Winslow, D. B. Kaufman

    Surgery, University of Wisconsin, Madison, WI

    *Purpose: PD-1 is a T cell co-inhibitory molecule involved in T cell exhaustion and antigen specific hypo-reactivity. Given the role of PD-1 signaling in the…
  • 2022 American Transplant Congress

    Successful Use of Anti-IL-6R Therapy to Achieve Cardiac Allograft Tolerance in Non-Human Primates

    C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, A. Dehnadi, T. Costa, M. Momodu, J. A. Morrissette, D. Muldoon, I. M. Hanekamp, J. S. Allan, G. Benichou, J. C. Madsen

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: In contrast to kidney allografts, attempts to achieve tolerance of isolated cardiac allografts in non-human primates (NHPs) using a mixed chimerism strategy have been…
  • 2022 American Transplant Congress

    Triple-Knockout Pig Red Blood Cells as Potential Sources for Blood Transfusion in Alloimmunized Patients with Sickle Cell Disease

    T. Yamamoto1, M. H. Bikhet2, H. Q. Nguyen2, Y. Cui2, M. Javed2, S. S. Raza2, D. Ayares3, H. Iwase2, H. Hara2, D. K. Cooper1

    1Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, 3Revivicor, Blacksburg, VA

    *Purpose: Blood transfusion remains important in the treatment of patients with sickle cell disease (SCD). However, alloimmunization after multiple blood transfusions is associated with patient…
  • 2022 American Transplant Congress

    A Model of Idiopathic Pneumonia Syndrome in Rhesus Macaques

    R. S. Bermea1, K. Ingersoll2, L. P. Hariri3, M. Warren2, L. Kean2, V. Tkachev2

    1Pulmonary & Critical Care Medicine, Massachusetts General Hospital, Boston, MA, 2Hematology/Oncology, Boston Children's Hospital, Boston, MA, 3Pathology, Massachusetts General Hospital, Boston, MA

    *Purpose: To create a model of idiopathic pneumonia syndrome (IPS), a deadly complication of hematopoietic stem cell transplantation (HSCT) in Rhesus macaques (RM).*Methods: RM were…
  • 2021 American Transplant Congress

    Interruption of Notch Signaling via Blockade of Delta-Like Ligand 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection

    A. J. Matar, B. P. Lovasik, Y. Dong, D. A. Faber, J. Habib, C. Breeden, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams

    Emory University Department of Surgery, Atlanta, GA

    *Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of Belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…
  • 2021 American Transplant Congress

    First Full Reversal of Diabetes in Non-human Primates (nhp) with Stem Cell Derived Islet-like-clusters (sc-ilcs)

    J. Lei1, S. Collins2, H. Deng1, Z. Yang1, A. Zhang1, C. Peters1, J. Zhang2, K. Boulanger2, M. Yu3, M. Rickels3, C. Liu3, R. Pop2, A. Naji3, D. Melton2, J. Markmann1

    1Surgery, Mass General, Boston, MA, 2Harvard Stem Cell Institute, Harvard University, Boston, MA, 3Surgery, Upenn, Philadelphia, PA

    *Purpose: Deceased donor allo-islet transplants (Tx) have demonstrated the ability of cell-based therapy to fully reverse T1D, however, an inadequate donor supply and frequent need…
  • 2021 American Transplant Congress

    P2X7 Receptor Activity Mediates Th17-Specific Self- and Alloreactivity in Non-Human Primates

    C. Little, J. Sullivan, W. Burlingham, D. Kaufman

    Department of Surgery, University of Wisconsin, Madison, WI

    *Purpose: The broadly expressed ATP-binding purinergic receptor, P2X7 (P2X7R) is involved in the Th17 mediated cellular immune response to allo- and select self-antigens (Collagen type…
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