Articles tagged "Preservation"

2017 American Transplant Congress
Combined Perfusion of Liver and Kidney Enhances the Protective Effects of Normothermic Perfusion on Donation After Cardiac Death Porcine Livers.
Z. Guo, F. Ji, X. He, G. Chen.
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Aims It has been showed that combined liver-kidney normothermic machine perfusion (NMP) is able to better maintain the circuit's biochemical milieu. Nevertheless, whether the combined…
2017 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Improves Function of Extreme Marginal Renal Grafts Subjected to Prolonged Ischemia.
P. Urbanellis,¹ M. Hamar,¹ I. Linares,¹ D. Kollmann,¹ C. Cassol,² R. John,² P. Yip,¹ I. Mucsi,¹ A. Ghanekar,¹ D. Bagli,³ D. Grant,¹ L. Robinson,⁴ M. Selzner.¹
¹Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Laboratory Medicine and Pathobiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ³Departments of Surgery (Urology) and Physiology, The Hospital for Sick Children, Toronto, ON, Canada; ⁴Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
Background: Normothermic ex-vivo kidney perfusion (NEVKP) is an emerging technique for renal graft preservation. We investigated whether NEVKP could promote improved marginal graft function compared…
2017 American Transplant Congress
Proteins in Preservation Fluid Predict Delayed Graft Function of Kidneys from Donors After Circulatory Death.
B. van Balkom,¹ H. Gremmels,¹ L. Ooms,⁴ R. Toorop,² F. Dor,⁵ O. de Jong,¹ L. Michielsen,¹ G. de Borst,² W. de Jager,³ A. van Zuilen,¹ M. Verhaar.¹
¹Nephrology and Hypertension, UMC Utrecht, Utrecht, Netherlands; ²Vascular Surgery, UMC Utrecht, Utrecht, Netherlands; ³Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands; ⁴Surgery, Erasmus MC, Rotterdam, Netherlands; ⁵Renal and Transplant Services, Imperial College Healthcare NHS Trust, London, United Kingdom
Background and objectivesKidney transplantation is the preferred treatment for end-stage kidney disease, and donor kidney shortage urges proper donor-recipient matching. Zero-hour biopsies provide predictive value…
2017 American Transplant Congress
Split Liver Ex-situ Oxygenated Machine Perfusion: A Novel Approach to Organ Preservation and Treatment.
N. Karimian,¹ V. Huang,¹ S. Geerts,¹ S. Mert,¹ I. Beijert,² F. Fontan,¹ M. Aburawi,¹ R. Porte,² K. Uygun,¹ J. Markmann,¹ H. Yeh.¹
¹Division of Transplantation, Massachusetts General Hospital, Boston; ²Division of Transplantation, University Medical Center Groningen, Groningen, Netherlands
Ex-situ machine perfusion (MP) is a promising method to improve organ viability prior to transplantation and is being used in various clinical trials worldwide. However,…
2017 American Transplant Congress
Cost-Effectiveness of Renal Machine Perfusion Use After Long Cold Ischemia Time.
A. Matos,¹ D. Malheiro,³ S. Morgado,¹ L. Requi[acirc]o-Moura,¹ M. Souza-Durão,^1,2 E. Tonato,¹ M. Nogueira,¹ M. Borrelli,¹ A. Pacheco-Silva.^1,2
¹Renal Transplant, Hospital Israelita Albert Einstein, São Paulo, Brazil; ²Nephrology, Universidade Federal de São Paulo, São Paulo, Brazil; ³Health Economics Department, Hospital Israelita Albert Einstein, São Paulo, Brazil
High cold ischemia time (CIT) and inadequate care of donors in Brazil lead to a high incidence of delayed graft function (DGF), 60%-70%, and as…
2016 American Transplant Congress
Impact of Machine Perfusion on Long-Term Kidney Transplant Outcomes.
S. Sandal,^1,2 X. Luo,² A. Massie,² M. Cantarovich,¹ D. Segev.²
¹MUHC, Montreal, Canada; ²JHU, Baltimore.
Machine perfusion (MP) has been shown to decrease DGF rates in kidney transplant (KT) recipients when compared with static cold storage (CS). However, there is…
2016 American Transplant Congress
Normothermic Ex Vivo Liver Perfusion (NEVLP) Using Steen Solution as Preservation Technique for Liver Transplantation-First Clinical Results.
M. Selzner, N. Goldaracena, J. Echeverri, I. Linares, M. Kaths, N. Selzner, M. Cattral, E. Renner, A. Ghanekar, L. Lilly, P. Greig, I. McGilvray, D. Grant.
Surgery, Toronto General Hospital, Toronto, Canada.
The European trial investigating NEVLP as preservation technique for liver transplantation uses Gelafusine, a non-FDA approved bovine derived gelatin-based perfusion solution. In contrast, we report…
2016 American Transplant Congress
Is Prolonged Cold Ischemia a Contraindication to Using Kidneys from Acute Kidney Injury Donors?
M. Khan,¹ A. Carrier,¹ H. El-Hennawy,¹ A. Farney,¹ J. Rogers,¹ G. Orlando,¹ A. Reeves-Daniel,² A. Palanisamy,² M. Gautreaux,³ S. Iskandar,³ W. Doares,⁴ S. Kaczmorski,⁴ R. Stratta.¹
¹Surgery, Wake Forest, Winston-Salem, NC; ²Internal Medicine, Wake Forest, Winston-Salem, NC; ³Pathology, Wake Forest, Winston-Salem, NC; ⁴Pharmacy, Wake Forest, Winston-Salem, NC.
Elevated deceased donor (DD) serum creatinine (SCr) levels and prolonged cold ischemia time (CIT) are major independent reasons for kidney discard following organ recovery. Many…
2016 American Transplant Congress
Hypothermic Machine Perfusion Is Also Beneficial for Deceased Donor Kidneys When Cold Ischemic Time Is Short and a Short Cold Ischemic Time Is Also Beneficial When Kidneys Are Machine Perfused.
J. Kox,¹ C. Moers,² D. Monbaliu,³ A. Strelniece,⁴ J.-W. Treckmann,⁵ I. Jochmans,³ H. Leuvenink,² L. van Heurn,¹ J. Pirenne,³ A. Paul,⁵ R. Ploeg.^2,6
¹Dept. of Surgery, Maastricht University Medical Center, Maastricht, Netherlands; ²Dept. of Surgery, University Medical Center Groningen, Groningen, Netherlands; ³Abdominal Transplant Surgery, University Hospital Leuven, Leuven, Belgium; ⁴Eurotransplant, Leiden, Netherlands; ⁵General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany; ⁶Oxford Transplant Centre, Oxford, United Kingdom.
IntroductionHypothermic machine perfusion (HMP) of deceased donor kidneys is associated with better outcome compared to static cold storage (SCS). It is generally assumed that HMP…
2016 American Transplant Congress
Influence of Pancreas Import and Cold Ischemia on Outcomes Following Pancreas Transplantation.
M. Khan,¹ H. El-Hennawy,¹ J. Rogers,¹ A. Farney,¹ G. Orlando,¹ A. Reeves-Daniel,² A. Palanisamy,² R. Stratta.¹
¹Surgery, Wake Forest, Winston-Salem, NC; ²Internal Medicine, Wake Forest, Winston-Salem, NC.
Proposed changes in pancreas transplant (PT) allocation may improve organ sharing but increase cold ischemia time (CIT). Methods: We performed a single center, retrospective study…