Articles tagged "Preservation"

2017 American Transplant Congress
Proteins in Preservation Fluid Predict Delayed Graft Function of Kidneys from Donors After Circulatory Death.
B. van Balkom,¹ H. Gremmels,¹ L. Ooms,⁴ R. Toorop,² F. Dor,⁵ O. de Jong,¹ L. Michielsen,¹ G. de Borst,² W. de Jager,³ A. van Zuilen,¹ M. Verhaar.¹
¹Nephrology and Hypertension, UMC Utrecht, Utrecht, Netherlands; ²Vascular Surgery, UMC Utrecht, Utrecht, Netherlands; ³Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands; ⁴Surgery, Erasmus MC, Rotterdam, Netherlands; ⁵Renal and Transplant Services, Imperial College Healthcare NHS Trust, London, United Kingdom
Background and objectivesKidney transplantation is the preferred treatment for end-stage kidney disease, and donor kidney shortage urges proper donor-recipient matching. Zero-hour biopsies provide predictive value…
2017 American Transplant Congress
Split Liver Ex-situ Oxygenated Machine Perfusion: A Novel Approach to Organ Preservation and Treatment.
N. Karimian,¹ V. Huang,¹ S. Geerts,¹ S. Mert,¹ I. Beijert,² F. Fontan,¹ M. Aburawi,¹ R. Porte,² K. Uygun,¹ J. Markmann,¹ H. Yeh.¹
¹Division of Transplantation, Massachusetts General Hospital, Boston; ²Division of Transplantation, University Medical Center Groningen, Groningen, Netherlands
Ex-situ machine perfusion (MP) is a promising method to improve organ viability prior to transplantation and is being used in various clinical trials worldwide. However,…
2017 American Transplant Congress
Cost-Effectiveness of Renal Machine Perfusion Use After Long Cold Ischemia Time.
A. Matos,¹ D. Malheiro,³ S. Morgado,¹ L. Requi[acirc]o-Moura,¹ M. Souza-Durão,^1,2 E. Tonato,¹ M. Nogueira,¹ M. Borrelli,¹ A. Pacheco-Silva.^1,2
¹Renal Transplant, Hospital Israelita Albert Einstein, São Paulo, Brazil; ²Nephrology, Universidade Federal de São Paulo, São Paulo, Brazil; ³Health Economics Department, Hospital Israelita Albert Einstein, São Paulo, Brazil
High cold ischemia time (CIT) and inadequate care of donors in Brazil lead to a high incidence of delayed graft function (DGF), 60%-70%, and as…
2017 American Transplant Congress
36 Hours of Ex-Vivo Warm Cellular Perfusion of Swine Liver Using the Organ Care System (OCS™) Liver with Excellent Functional, Metabolic and Histological Outcomes.
J. Magliocca,¹ J. Markmann,² M. Abouljoud,³ M. Ghobrial,⁴ A. Demetris.⁵
¹Division of Transplant Surgery Department of Surgery, The Emory Transplant Center, Atlanta, GA; ²Department of Surgery Division of Transplantation, Massachusetts General Hospital, Boston, MA; ³Transplant Institute and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ⁴Surgery - General, Houston Methodist Hospital, Houston, TX; ⁵Department of Transplant Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
Cold storage preservation results in ischemia/reperfusion injury to the donor liver, it lacks any resuscitative or assessment capabilities. The OCS™ Liver maintains livers in a…
2017 American Transplant Congress
Assessment and Transplantation of Declined Human Kidneys Using Ex-Vivo Normothermic Kidney Perfusion.
S. Hosgood,¹ M. Hamed,¹ A. Sawpaul,² R. Figueiredo,² K. Saeb-Parsy,¹ C. Wilson,² M. Nicholson.¹
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom; ²Transplantation, Transplant Institute, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, United Kingdom
PurposeThe aim of this study was to make more kidneys available for transplantation by using ex-vivo normothermic kidney perfusion (EVKP) technology to assess the quality…
2016 American Transplant Congress
Replacing Cold Storage with Normothermic Ex Vivo Kidney Perfusion Improves Function of Grafts Retrieved After Circulatory Death (DCD).
J. Kaths,^1,2 Y.-M. Chun,¹ D. Cen,¹ J. Echeverri,¹ I. Linares,¹ P. Yip,³ R. John,³ D. Bagli,⁴ I. Mucsi,⁵ A. Ghanekar,¹ D. Grant,¹ L. Robinson,² M. Selzner.¹
¹Department of Surgery, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada; ³Laboratory Medicine & Pathobiology, Toronto General Hospital, Toronto, ON, Canada; ⁴Departments of Surgery (Urology) & Physiology, The Hospital for Sick Children, Toronto, ON, Canada; ⁵Department of Medicine, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
Normothermic ex vivo kidney perfusion (NEVKP) and avoidance of static cold storage (SCS) is an attractive strategy to minimize injury of DCD kidney grafts. We…
2016 American Transplant Congress
Hydrogen Sulfide Treatment Mitigates Donor Tissue Necrosis During Prolonged Cold Storage and Improves Survival Following Allogeneic Renal Transplantation.
I. Lobb,^1,3 W. Liu,² J. Jiang,³ D. Lian,³ A. Sener.^1,3,4
¹Microbiology and Immunology, Western University Canada, London, ON, Canada; ²Pathology, Western University Canada, London, ON, Canada; ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ⁴Surgery, Western University Canada, London, ON, Canada.
Organ procurement is inherently associated with ischemia-reperfusion injury (IRI), resulting from loss and subsequent restoration of blood flow, which is detrimental to short- and long-term…
2016 American Transplant Congress
Prolonged Normothermic Ex Vivo Kidney Perfusion Is a Safe Preservation Technique for Kidney Transplantation: A New Opportunity for the Storage, Assessment and Repair of Kidney Grafts.
J. Kaths,^1,2,3 J. Echeverri,¹ N. Goldaracena,¹ K. Louis,¹ Y.-M. Chun,¹ I. Linares,^1,3 A. Wiebe,¹ P. Yip,⁵ R. John,⁵ I. Mucsi,⁶ A. Ghanekar,¹ D. Bagli,^7,3 D. Grant,¹ L. Robinson,^2,3 M. Selzner.^1,3
¹Department of Surgery, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada; ³Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ⁴Department of General, Visceral, and Transplant Surgery, University Medical Center Mainz, Mainz, Germany; ⁵Laboratory Medicine & Pathobiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ⁶Department of Medicine, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ⁷Departments of Surgery (Urology) & Physiology, The Hospital for Sick Children, Toronto, ON, Canada.
Hypothermic kidney storage causes preservation injury. We investigated whether SCS can be safely replaced with prolonged normothermic ex vivo kidney perfusion (NEVKP). Right kidneys were…
2016 American Transplant Congress
Signs of a Dying Organ: Beyond Resistance in Subnormothermic Kidney Perfusion.
M. Blum, D. Urcuyo, Q. Liu, B. Soliman, T. Okamoto, D. Goldfarb, C. Quintini.
Cleveland Clinic, Cleveland, OH.
Purpose: In hypothermic machine preservation of the kidney, resistance is often used to assess organ quality. Since no prognostic standard yet exists for subnormothermic ex-vivo…
2016 American Transplant Congress
Ex-Vivo Normothermic Perfusion for Assessment of High Risk Deceased Donor Kidneys for Transplantation.
S. Kabagambe, I. Palma, Y. Smolin, T. Boyer, I. Palma, J. Sageshima, C. Santhanakrishnan, C. Troppmann, J. McVicar, R. Perez.
Surgery, University of California-Davis, Sacramento, CA.
Despite the organ shortage, many procured deceased donor kidneys are deemed too high risk for failure and discarded. Ex-vivo normothermic perfusion (EVNP) may be useful…