ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Is Prolonged Cold Ischemia a Contraindication to Using Kidneys from Acute Kidney Injury Donors?

M. Khan,1 A. Carrier,1 H. El-Hennawy,1 A. Farney,1 J. Rogers,1 G. Orlando,1 A. Reeves-Daniel,2 A. Palanisamy,2 M. Gautreaux,3 S. Iskandar,3 W. Doares,4 S. Kaczmorski,4 R. Stratta.1

1Surgery, Wake Forest, Winston-Salem, NC
2Internal Medicine, Wake Forest, Winston-Salem, NC
3Pathology, Wake Forest, Winston-Salem, NC
4Pharmacy, Wake Forest, Winston-Salem, NC.

Meeting: 2016 American Transplant Congress

Abstract number: 275

Keywords: Cadaveric organs, Kidney transplantation, Outcome, Preservation

Session Information

Date: Monday, June 13, 2016

Session Name: Concurrent Session: Acute Kidney Injury and Recovery after Transplantation

Session Time: 4:30pm-6:00pm

 Presentation Time: 5:42pm-5:54pm

Location: Ballroom C

Related Abstracts
  • Excellent Outcomes with Transplantation of Kidneys (KTx) from Deceased Donors (DDs) with Acute Kidney Injury (AKI)
  • Influence of Cold Ischemia Time in Combination With Donor Ischemic Events on Kidney Transplant Outcomes

Elevated deceased donor (DD) serum creatinine (SCr) levels and prolonged cold ischemia time (CIT) are major independent reasons for kidney discard following organ recovery. Many kidneys are declined locally because of acute kidney injury (AKI), which results in longer CIT as these kidneys are offered regionally and then nationally. The study purpose was to analyze the combined effect of these 2 factors on kidney transplant (KT) outcomes. Methods: We performed a single center retrospective analysis in adult DD KT patients (pts) receiving AKI donor kidneys. AKI was defined as doubling in the admit SCr and terminal SCr >2.0 mg/dl. Outcomes were stratified according to longer CIT categories. Delayed graft function (DGF) was defined as the need for dialysis in the 1st week post-KT. Results: Since 1/1/07, we performed 118 KTs from 89 AKI DDs. Mean DD age was 35 years; mean DD admit and terminal SCr levels were 1.2 mg/dl and 3.1 mg/dl, respectively. 27 KTs (23%) had CITs <20 hrs, 52 (44%) 20-<30 hrs, 30 (25%) 30-<40 hrs, and 9 (8%) ≥40 hrs. The proportion of imported kidneys (66% overall) increased with longer CIT category (30%, 67%, 90% and 89%, respectively, p<0.0001). Most kidneys (87%) were managed with both cold storage and machine perfusion (mean pump time 12.2 hrs, mean total CIT 26.3 hrs). The overall incidence of DGF was 41.5%; the DGF rate with longer CIT category was 30%, 48%, 33%, and 67%, respectively (p=NS). With mean follow-up of 52 months, overall pt and kidney graft survival rates were 91% and 81%, respectively. Death-censored graft survival (DCGS) rates were 84% and 88% for pts with and without DGF (p=NS). DCGS rates were 92% in pts with CIT <20 hrs compared to 85% in those with CIT ≥20 hrs (p=NS). In the 9 pts with CITs ≥40 hrs, the 4-year DCGS rate was 100%. Conclusions: These findings suggest that the presence of both AKI and prolonged CIT may not adversely influence intermediate-term outcomes, particularly when imported kidneys are placed on short-term machine preservation prior to KT. The presence of DGF likewise does not affect outcomes. Discard of AKI donor kidneys because of projected long CIT is not warranted.

CITATION INFORMATION: Khan M, Carrier A, El-Hennawy H, Farney A, Rogers J, Orlando G, Reeves-Daniel A, Palanisamy A, Gautreaux M, Iskandar S, Doares W, Kaczmorski S, Stratta R. Is Prolonged Cold Ischemia a Contraindication to Using Kidneys from Acute Kidney Injury Donors? Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Khan M, Carrier A, El-Hennawy H, Farney A, Rogers J, Orlando G, Reeves-Daniel A, Palanisamy A, Gautreaux M, Iskandar S, Doares W, Kaczmorski S, Stratta R. Is Prolonged Cold Ischemia a Contraindication to Using Kidneys from Acute Kidney Injury Donors? [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/is-prolonged-cold-ischemia-a-contraindication-to-using-kidneys-from-acute-kidney-injury-donors/. Accessed March 6, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Home
  • Search
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.