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Normothermic Ex Vivo Liver Perfusion (NEVLP) Using Steen Solution as Preservation Technique for Liver Transplantation-First Clinical Results.

M. Selzner, N. Goldaracena, J. Echeverri, I. Linares, M. Kaths, N. Selzner, M. Cattral, E. Renner, A. Ghanekar, L. Lilly, P. Greig, I. McGilvray, D. Grant.

Surgery, Toronto General Hospital, Toronto, Canada.

Meeting: 2016 American Transplant Congress

Abstract number: 21

Keywords: Liver preservation, Liver transplantation, Preservation

Session Information

Date: Sunday, June 12, 2016

Session Name: Concurrent Session: Donor Management: All Organs

Session Time: 2:30pm-4:00pm

 Presentation Time: 2:42pm-2:54pm

Location: Room 306

Related Abstracts
  • Prolonged Normothermic Ex Vivo Kidney Perfusion Is a Safe Preservation Technique for Kidney Transplantation: A New Opportunity for the Storage, Assessment and Repair of Kidney Grafts.
  • Normothermic Acellular Ex Vivo Liver Perfusion (NEVLP): Development of a New Method for the Storage, Assessment, and Repair of Marginal Liver Grafts

The European trial investigating NEVLP as preservation technique for liver transplantation uses Gelafusine, a non-FDA approved bovine derived gelatin-based perfusion solution. In contrast, we report the first clinical NEVLP experience with Steen solution, a human-based albumin-based perfusate approved for lung perfusion.

Methods: Eight human liver grafts were preserved on the Metra device and perfused at 37C with Steen solution plus 3 units of erythrocytes. Epoprostenol, Taurocholic acid, heparin, and insulin were added during the perfusion. Data is expressed as median and range.

Results: Eight liver transplantations (6 NDD, 2 DCD) were performed. Donor age and BMI were 46 years (22-60yrs) and 24 (20-26). Preservation time was 11hr (9-13) with a perfusion duration of 6 hr (4-8hrs). Peak ALT level during perfusion was 444 U/L (152 – 1460U/L). Lactate decreased in all grafts during the perfusion. Bile production during perfusion was 10ml/hr (7-24ml/hr). AST and ALT levels 24hrs after transplantation were 312U/L (54 – 2858U/L) and 156U/L (21 – 1383U/L) respectively. All patients had excellent graft function with INR and bilirubin levels of 1.2 (1.05 – 1.3) and 1.3mg/dl (0.8-13mg/dl) 3 days after transplantation. ICU and hospital stay were 1day (0-5days) and 12days (9-26days). Two patients were fast tracked without post-transplant ICU care. No severe complication (Dindo-Clavien >3) occurred after transplantation.

Conclusion: Normothermic ex vivo perfusion with the Metra device using Steen solution is feasible and can result in good outcome after human liver transplantation. Using FDA approved Steen solution will avoid a potential regulatory barrier (the use of bovine based materials) to the clinical development of NEVLP in North America.

CITATION INFORMATION: Selzner M, Goldaracena N, Echeverri J, Linares I, Kaths M, Selzner N, Cattral M, Renner E, Ghanekar A, Lilly L, Greig P, McGilvray I, Grant D. Normothermic Ex Vivo Liver Perfusion (NEVLP) Using Steen Solution as Preservation Technique for Liver Transplantation-First Clinical Results. Am J Transplant. 2016;16 (suppl 3).

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To cite this abstract in AMA style:

Selzner M, Goldaracena N, Echeverri J, Linares I, Kaths M, Selzner N, Cattral M, Renner E, Ghanekar A, Lilly L, Greig P, McGilvray I, Grant D. Normothermic Ex Vivo Liver Perfusion (NEVLP) Using Steen Solution as Preservation Technique for Liver Transplantation-First Clinical Results. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/normothermic-ex-vivo-liver-perfusion-nevlp-using-steen-solution-as-preservation-technique-for-liver-transplantation-first-clinical-results/. Accessed April 22, 2021.

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