ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Preservation"

  • 2022 American Transplant Congress

    Intraabdominal Hypertension in the Death by Neurologic Criteria Organ Donor

    C. Schardein1, M. Moncure2, S. Craft1, S. Sanders3

    1General Surgery, University of Missouri at Kansas City, Kansas City, MO, 2Trauma and Critical Care Surgery, University of Missouri at Kansas City, Kansas City, MO, 3MTN, Kansas City, MO

    *Purpose: This study attempts to identify the incidence of abdominal compartment syndrome (ACS) within the death by neurological criteria organ donor population, provide timely intervention,…
  • 2022 American Transplant Congress

    Early vs. Late Heparin Administration After Declaration of Death in DCD Donors Does Not Impact Short Term Outcomes in Kidney Transplantation

    A. M. Hawxby, R. Ketcham, R. Squires, J. P. Orlowski, H. Solomon, C. Hostetler

    Organ Recovery, LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK

    *Purpose: Kidneys from Donation after Cardiac Death (DCD) donors are well-known to have satisfactory outcomes post-transplant. In DCD donors, heparin is typically given immediately prior…
  • 2022 American Transplant Congress

    Perfusate Il-6 Levels During Liver Nmp Are Predictive For Hemodynamic Response And Catecholamine Demand After Reperfusion In The Recipient

    A. Weissenbacher1, S. Mathis2, B. Cardini1, C. Bogensperger1, G. Putzer2, L. Gasteiger2, T. Resch1, R. Oberhuber1, D. Öfner1, T. Hell3, J. Martini2, S. Schneeberger1

    1Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria, 2Department of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria, 3Department of Mathematics, Faculty of Mathematics, Computer Science and Physics, University of Innsbruck, Innsbruck, Austria

    *Purpose: Normothermic liver preservation (NMP) has become a clinical routine at several transplant centres. Reperfusion-syndrome occurs less often in recipients of NMP-livers compared to cold…
  • 2022 American Transplant Congress

    Xenogeneic Cross-Circulation Supports Ex Vivo Human Livers for 24 Hours

    W. K. Wu1, R. Ukita2, Y. J. Patel2, I. A. Ziogas3, M. Cortelli2, M. Mentz2, J. R. Talackine2, S. A. Francois2, N. L. Cardwell2, J. W. Stokes2, S. P. Alexopoulos3, M. Bacchetta2

    1Hepatobiliary Surgery and Liver Transplantation; Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, 2Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, 3Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN

    *Purpose: Despite increasing use of machine perfusion as an organ preservation and rescue technique in liver transplantation, significant organ shortages and waitlist mortality highlight a…
  • 2022 American Transplant Congress

    Evaluation of UW-Based Solutions Formulated to Be Anti-Apoptotic and Neuroprotective of Retinal Ganglion Cells (RGCs) Following Whole Eye Transplantation (WET) in a Rat Model

    N. J. Khatter1, Y. Wang1, B. Li1, C. R. Owens1, A. H. Jani2, C. A. Huang1, R. W. Nickells3, A. A. Su1, K. M. Washington1

    1Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO, 2Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, 3Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI

    *Purpose: As vascularized composite allotransplantation (VCA) of an intact optical system to restore vision requires overcoming RGC apoptosis caused by ischemia reperfusion injury, UW and…
  • 2022 American Transplant Congress

    Regulation of Cell Death During Cold Preservation of Marginal Human Kidneys

    J. R. DiRito1, G. Chickering1, J. Langford1, D. Stern1, D. Qin2, S. Hosgood3, M. Nicholson3, J. Pober4, E. Gavathiotis5, R. Kitsis5, G. Tietjen1

    1Surgery, Yale School of Medicine, New Haven, CT, 2Albert Einstein College of Medicine, Bronx, NY, 3Surgery, University of Cambridge, Cambridge, United Kingdom, 4Immunology, Yale School of Medicine, New Haven, CT, 5Albert Einstein College of Medicine, Bronx, NM

    *Purpose: Each year thousands of kidneys from marginal donors are discarded due to an increased sensitivity to injury during cold storage and consequently a high…
  • 2022 American Transplant Congress

    Addressing the Organ Shortage, Improving Transplant Longevity, and Enabling Minimally Invasive Kidney Transplantation: Development of an Intraoperative Kidney Anastomosis Facilitation and Regelation Device

    K. S. Hansen1, R. Meier2, J. Gardner1

    1University of California San Francisco, San Francisco, CA, 2Division of Transplant Surgery, University of Maryland, San Francisco, CA

    *Purpose: Second warm ischemia time (SWIT) of a renal allograft during anastomosis increases rates of delayed graft function and premature graft failure. In the setting…
  • 2022 American Transplant Congress

    Novel Portable Hypothermic Cardiac Preservation Device Enhances Cardiac Viability and Function of the Isolated Porcine Hearts

    K. Andrijauskaite, R. J. Veraza, R. P. Lopez, E. C. Cisneros, I. J. Jessop, M. D. Watt, L. Bunegin

    Vascular Perfusion Solutions, Inc, San Antonio, TX

    *Purpose: Cardiac heart transplantation is the gold standard for treating end-stage heart failure; however, the list of patients waiting for heart transplants continues to increase.…
  • 2022 American Transplant Congress

    Analysis of Tissue and Effluent Damage Associated Molecular Patterns Following Hypothermic Oxygenated Machine Perfusion vs Static Cold Storage in Liver Transplantation

    G. G. Panayotova, Y. Qin, S. Simonishvili, T. Ayorinde, F. Paterno, L. Brown, A. Amin, K. E. Lunsford, J. V. Guarrera

    Transplant Surgery, Rutgers New Jersey Medical School, Newark, NJ

    *Purpose: Hypothermic Oxygenated Machine Perfusion (HMP-O2) results in decreased ischemia/reperfusion injury (IRI) after liver transplantation; however, the molecular pathways of protection are largely unexplored. In…
  • 2022 American Transplant Congress

    Artificial Mitochondria Transfer to Mitigate Ischemic Damage in an In Vitro Model of Tubular Injury and in an Ex Vivo Porcine Model of DCD Renal Transplantation

    A. Rossi1, S. Sedrakyan2, F. Montali3, C. Aardena4, N. Abraham5, A. Barbas5, L. N. Byers6, C. Palles7, A. Asthana6, J. Robertson4, L. Perin2, R. Senger4, B. Bussolati1, G. Orlando8

    1Un. of Turin, Turin, Italy, 2Children Hospital, Los Angeles, CA, 3Un. of L'Aquila, L'Aquila, Italy, 4VA Tech, Blacksburg, VA, 5Duke, Durham, NC, 6WFIRM, Winston Salem, NC, 7University of Florida, Gainesville, FL, 8Wake Forest Baptist, Winston-Salem, NC

    *Purpose: We aimed at assessing whether artificial mitochondrial transfer (AMT) mitigates renal injury in an in vitro model of tubular damage and in an ex…
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