Articles tagged "Preservation"

2018 American Transplant Congress
A Cost Analysis on Normothermic Machine Perfusion at a Single Center
D. Pezzati, Q. Liu, H. Hassan, G. Iuppa, L. Hernandez, G. D'Amico, T. Diago Uso, B. Heghtsad, C. Miller, C. Quintini.
General Surgery, Cleveland Clinic, Cleveland, OH.
INTRODUCTION: Normothermic machine perfusion (NMP) for liver transplantation is a novel and promising technique.One of the concerns related to its usage is the high cost.The…
2018 American Transplant Congress
Ischemia-Free Liver Transplantation for Fatty Liver Grafts in Human
W. Ju, S. Huang, Z. Guo, G. Chen, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
BACKGROUND&AIMS: Fatty liver diseases have led to a continuous increase of available donor livers containing fat. Fatty liver grafts were identified as an independent risk…
2018 American Transplant Congress
Hypothermic Oxygenated Machine Perfusion in Liver and Kidney Transplantation of Extended Criteria Donors: A Phase-1 of Clinical Trial
M. Ravaioli,¹ V. De Pace,¹ M. Cescon,¹ M. Del Gaudio,¹ V. R. Bertuzzo,¹ A. Siniscalchi,¹ A. D'Errico,² G. Comai,² G. La Manna,² A. D. Pinna.¹
¹General Surgery and Transplantation, University of Bologna Sant'Orsola - Malpighi Hospital, Bologna, Emilia Romagna, Italy; ²Experimental Diagnostic and Specialty Medicine, University of Bologna Sant'Orsola- Malpighi Hospital, Bologna, Emilia Romagna, Italy.
In the field of liver (LT) and kidney transplantation (KT), extended criteria donors (ECD) offer an additional organ source that is more vulnerable for early…
2018 American Transplant Congress
One-Pump versus Two-Pump Normothermic Ex Vivo Perfusion Machines in Discarded Human Livers
A. Hassan, Q. Liu, D. Pezzati, A. Nassar, B. Soliman, M. Blum, P. Grady, G. Iuppa, T. Uso, J. Fung, K. Abu-Elmagd, C. Quintini.
Transplant Surgery, Cleveland Clinic, Cleveland.
Introduction:Physiologic flows and pressures need to be provided by the ex vivo liver perfusion device. We hypothesized that the 1-pump designed machines would provide the…
2018 American Transplant Congress
Resuscitation and Viability Testing of Initially Declined Livers Using Sequential Hypo- and Normothermic Machine Perfusion with an Acellular Fluid
Y. de Vries,^1,2 A. Matton,^1,2 S. Karangwa,^1,2 M. Nijsten,³ R. de Kleine,² A. van den Berg,⁴ V. de Meijer,² P. Meyer,⁵ M. de Boer,² R. Porte.²
¹Surgical Research Laboratory, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; ²Section of HPB Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, Netherlands; ³Department of Critical Care, University Medical Center Groningen, Groningen, Netherlands; ⁴Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands; ⁵Department of Anesthesiology, University Medical Center Groningen, Groningen, Netherlands.
While end-ischemic dual hypothermic oxygenated machine perfusion (DHOPE) resuscitates mitochondria and reduces ischemia-reperfusion injury, normothermic machine perfusion (NMP) allows for ex-situ functional testing of donor…
2018 American Transplant Congress
Unraveling the Neuroimmunological Pathways Surrounding Brain Death: Systematic Study of Clinically Relevant Serum Biomarker Changes during Donor Management from Admission to Procurement
K. Bera, M. LoFaro, H. Huang, S. Maslau, R. Ploeg.
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Donation after brain death (BD) remains an important source of transplanted organs worldwide and it has been shown that BD causes a hostile environment with…
2018 American Transplant Congress
Assessment of Hepatic Ischemia-Reperfusion Injuries by NRF2-Dependent Transcriptional Activities of Bile Transporters in Rats
J. Kim,¹ A. Martin,¹ J. Yee,¹ L. Fojut,¹ A. Geurts,² K. Oshima,³ M. Zimmerman,¹ J. Hong.¹
¹Surgery, Medical College of Wisconsin, Milwaukee, WI; ²Physiology, Medical College of Wisconsin, Milwaukee, WI; ³Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: The effect of hepatic ischemia and reperfusion injury (IRI) on bile transporter (BT) gene expression and the role of Nrf2 in BT regulation during…
2018 American Transplant Congress
A Novel Preservation Solution for Lung That Improves Cell Viability and Tissue Architecture
J. Friedman,¹ M. Samamrco,¹ L. Marrero,¹ B. Bunnell,¹ D. Spyropoulos.²
¹Tulane University, New Orleans; ²MUSC, Charleston.
Backgroud: Only 20% of donor lungs are used for transplant and 10 y survival of recipients is low. Many patients die within 30 d of…
2018 American Transplant Congress
A Proteomic Analysis of Kidneys Subjected to Normothermic Ex Vivo Kidney Perfusion (NEVKP) Demonstrates That Metabolism is an Important Determinant of Kidney Function Following Warm Ischemia
A. Konvalinka,^1,4 T. Tokar,² S. Reid,⁴ P. Urbanellis,⁴ M. Hamar,⁴ M. Kaths,⁴ I. Jurisica,² L. Robinson,^4,3 M. Selzner.^4,5
¹Medicine/Nephrology, University Health Network, Toronto, ON, Canada; ²Medical Biophysics/Computer Science, University of Toronto, Toronto, ON, Canada; ³Pediatrics/Nephrology, Hospital for Sick Children, Toronto, ON, Canada; ⁴Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ⁵Surgery/General Surgery, University Health Network, Toronto, ON, Canada.
Kidney transplantation reduces mortality compared to staying on dialysis, incentivizing the use of marginal kidneys in face of organ shortage. These marginal kidneys after cardiocirculatory…
2018 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Restores the Genetic Profile of Marginal Kidney Grafts Subjected to Warm Ischemia
P. Urbanellis,¹ M. Hamar,¹ I. Linares,¹ D. Kollmann,¹ S. Ganesh,¹ R. John,¹ P. Yip,¹ I. Mucsi,¹ A. Ghanekar,¹ D. Bagli,² A. Konvalinka,¹ D. Grant,¹ L. Robinson,² M. Selzner.¹
¹University Health Network, Toronto, ON, Canada; ²SickKids Hospital, Toronto, ON, Canada.
Background: Increasing evidence demonstrates the superiority of normothermic ex-vivo kidney perfusion (NEVKP) over cold storage (CS) for marginal renal grafts. To account for this improvement,…