ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Impact of Machine Perfusion on Long-Term Kidney Transplant Outcomes.

S. Sandal,1,2 X. Luo,2 A. Massie,2 M. Cantarovich,1 D. Segev.2

1MUHC, Montreal, Canada
2JHU, Baltimore.

Meeting: 2016 American Transplant Congress

Abstract number: 316

Keywords: Graft failure, Kidney transplantation, Preservation

Session Information

Date: Monday, June 13, 2016

Session Name: Concurrent Session: Kidney Transplant Recipient: Long Term Outcomes Session I

Session Time: 4:30pm-6:00pm

 Presentation Time: 5:30pm-5:42pm

Location: Veterans Auditorium

Related Abstracts
  • Renal Resistance Measured During Pulsatile Perfusion and Long-Term Kidney Transplant Outcomes
  • Impact of Machine Perfusion After Long Static Cold Storage On Delayed Graft Function Incidence and Duration and Time to Hospital Discharge

Machine perfusion (MP) has been shown to decrease DGF rates in kidney transplant (KT) recipients when compared with static cold storage (CS). However, there is a paucity of data examining the effect of MP on graft outcomes, particularly those beyond 1 year.

Methods: We conducted a retrospective analysis of 78,207 adult deceased-donor KT recipients using SRTR data from 2006-2013. The cohort was stratified by donor type (SCD-DBD, SCD- DCD, ECD-DBD, ECD-DCD). Outcomes of interest were DGF, all cause graft failure, death-censored graft failure (DCGF) and mortality. We used Cox regression to model the association between MP and graft outcomes, and logistic regression for DGF, adjusting for recipient, donor and transplant characteristics.

Results: When compared with SCD-DBD kidneys (26.7%), more ECD-DCD (87.6%), SCD-DCD (72.4%) and ECD-DBD (53.2%) kidneys underwent MP. MP use was associated with lower risk of DGF in SCD-DBD (OR 0.53, p<0.01), SCD-DCD (OR 0.62 p<0.01) and ECD-DBD (OR 0.53, p<0.01) KTs but not in ECD-DCD KTs (OR 0.77, p=0.3). MP did not affect DCGF, except ECD-DCD KTs where it was associated with 44% lower risk in the 1st year, and ECD-DBD KTs where it was associated with a 15% increased risk after the 1st year

Table 1: Hazard ratio for MP use and graft outcomes; significant values in bold

 

0-1 year

95% CI

p value

0-5 year

95% CI

p value

DCGF

SCD-DBD

1.03

0.93-1.14

0.5

1.05

0.97-1.14

0.2

SCD-DCD

1.11

0.90-1.38

0.3

1.14

0.92-1.42

0.2

ECD-DBD

1.04

0.91-1.19

0.5

1.15

1.01-1.31

0.04

ECD-DCD

0.56

0.32-0.98

0.04

0.73

0.34-1.54

0.4

All cause graft failure

SCD-DBD

1.02

0.94-1.10

0.7

1

0.94-1.07

0.9

SCD-DCD

1.11

0.94-1.32

0.2

1.11

0.95-1.30

0.2

ECD-DBD

0.99

0.89-1.10

0.8

1

0.91-1.11

0.9

ECD-DCD

0.59

0.38-0.91

0.019

0.91

0.55-1.51

0.7

Mortality

SCD-DBD

1.01

0.91-1.13

0.8

0.97

0.89-1.05

0.2

SCD-DCD

1.19

0.93-1.51

0.2

1.15

0.95-1.40

0.1

ECD-DBD

0.96

0.83-1.11

0.6

0.96

0.86-1.07

0.5

ECD-DCD

0.68

0.33-1.42

0.3

0.91

0.54-1.54

0.7

. There was no association between MP use and recipient survival.

Conclusion: Despite lowering DGF rates, MP seems to harm ECD-DBD kidneys; however, in all other categories of donors, there seems to be improvement in either DGF and/or allograft loss.

CITATION INFORMATION: Sandal S, Luo X, Massie A, Cantarovich M, Segev D. Impact of Machine Perfusion on Long-Term Kidney Transplant Outcomes. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Sandal S, Luo X, Massie A, Cantarovich M, Segev D. Impact of Machine Perfusion on Long-Term Kidney Transplant Outcomes. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/impact-of-machine-perfusion-on-long-term-kidney-transplant-outcomes/. Accessed March 2, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.