Articles tagged "Polymorphism"

2015 American Transplant Congress
First Dose Tacrolimus Level Is Better Than CYP3A5 Genotyping in Prediction of Target Tacrolimus Dose
N. Townamchai,¹ W. Chancharoenthana,¹ S. Wattanatorn,¹ S. Vadcharavivad,² P. Chariyavilaskul,³ A. Leelahavanichkul,⁴ Y. Avihingsanon,¹ K. Praditpornsilpa.¹
¹Department of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand; ²Department of Pharmacy Practice, Chulalongkorn University, Bangkok, Thailand; ³Pharmacokinetic Research Unit, Chulalongkorn University, Bangkok, Thailand; ⁴Department of Microbiology, Chulalongkorn University, Bangkok, Thailand.
Background: Tacrolimus dose highly varies among Asian kidney transplant recipients. This can be explained by variety of CYP3A5 expression. CYP3A5 genotyping is highly recommended for…
2015 American Transplant Congress
Identification of Genetic Variants Associated With Variation of Tacrolimus Levels in African Americans Using GWAS
W. Oetting,¹ D. Schladt,² W. Guan,¹ A. Israni,² R. Remmel,¹ C. Dorr,² K. Sanghavi,¹ R. Mannon,³ B. Herrera,⁴ A. Matas,¹ D. Salomon,⁵ P. Kwok,⁴ P. Jacobson,¹ for DeKAF Genomics.¹
¹Univ. of Minnesota, Minneapolis; ²Minneapolis Medical Research Foundation, Minneapolis; ³Univ. of Alabama, Birmingham; ⁴Univ. of California, San Francisco; ⁵Scripps Research Center, La Jolla.
African American kidney transplant recipients (AA) have a higher incidence of allograft failure when compared to Caucasians. We have previously reported that tacrolimus troughs (TT)…