Articles tagged "Polymorphism"

2017 American Transplant Congress
Benefits of Mycophenolate Sodium Over Mycophenolate Mofetil in Renal Transplant Patients Carrying UGT1A9 Polymorphism.
N. Calvo Romero, I. Perez-Flores, A. Shabaka, M. Moreno De La Higuera, B. Rodriguez-Cubillo, J. Delgado, M. Calvo, V. Lopez De La Manzanara, A. Sanchez-Fructuoso.
Nephrologist, Hospital Clínico San Carlos, Madrid, Spain
Aims: To analyze the differences in mycophenolic acid (MPA) pharmacokinetics and digestive side effects in renal transplant recipients on treatment with Mycophenolate mofetil (MMF) and…
2017 American Transplant Congress
Impact of Polymorphisms of UGT 1 A9 on the Prognosis of Renal Transplant Patients. Association with Digestive Tumors.
N. Calvo, I. Perez-Flores, A. Shabaka, M. Moreno, B. Rodriguez-Cubillo, J. Delgado, M. Calvo, A. Sanchez-Fructuoso.
Nephrologist, Hospital Clinico San Carlos, Madrid, Spain
The aim of this study was to evaluate the distribution of UGT1A9 promoter region T-275A and C-2152T single nucleotide polymorphisms (SNPs) in stable transplant patients…
2016 American Transplant Congress
Differences in Tacrolimus Troughs and Doses Between Caucasians and African Americans with Two CYP3A5 Loss-of-Function Alleles: Looking Beyond CYP3A5 Expression.
W. Oetting,¹ D. Schladt,² W. Guan,¹ R. Remmel,¹ C. Dorr,² K. Sanghavi,¹ A. Matas,¹ R. Mannon,³ A. Israni,² P. Jacobson,¹ For DeKAF Genomics,¹ GEN-03 Investigators.¹
¹University of Minnesota, Minneapolis, MN; ²Hennepin County Medical Center and Minneapolis Medical Research Foundation, Minneapolis, MN; ³University of Alabama, Birmingham, AL.
Higher tacrolimus (TAC) dose requirements and lower TAC troughs (TT) in African Americans (AA) relative to Caucasians (CA) have been presumed to be due to…
2015 American Transplant Congress
Single Nucleotide Polymorphisms (SNPs) Associated With Acute Rejection in European American Kidney Transplant Recipients: A Genome Wide Association Study (GWAS)
A. Israni,¹ C. Dorr,¹ M. Miller,² D. Schladt,¹ K. Sanghavi,³ A. Muthusamy,¹ R. Remmel,³ W. Guan,⁴ B. Wu,⁴ W. Oetting,³ P. Jacobson,³ A. Matas,⁵ For DeKAF Genomics & GEN03 Investigators.¹
¹Medicine, MMRF, Hennepin County Medical Center, Minneapolis, MN; ²Psychology, University of MN, Minneapolis, MN; ³Pharmacy, University of MN, Minneapolis, MN; ⁴Biostatistics, University of MN, Minneapolis, MN; ⁵Surgery, University of MN, Minneapolis, MN.
Purpose: Acute rejection (AR) is associated with increased risk of allograft loss. Therefore, we conducted a GWAS to determine SNPs associated with AR in a…
2015 American Transplant Congress
First Dose Tacrolimus Level Is Better Than CYP3A5 Genotyping in Prediction of Target Tacrolimus Dose
N. Townamchai,¹ W. Chancharoenthana,¹ S. Wattanatorn,¹ S. Vadcharavivad,² P. Chariyavilaskul,³ A. Leelahavanichkul,⁴ Y. Avihingsanon,¹ K. Praditpornsilpa.¹
¹Department of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand; ²Department of Pharmacy Practice, Chulalongkorn University, Bangkok, Thailand; ³Pharmacokinetic Research Unit, Chulalongkorn University, Bangkok, Thailand; ⁴Department of Microbiology, Chulalongkorn University, Bangkok, Thailand.
Background: Tacrolimus dose highly varies among Asian kidney transplant recipients. This can be explained by variety of CYP3A5 expression. CYP3A5 genotyping is highly recommended for…
2015 American Transplant Congress
Identification of Genetic Variants Associated With Variation of Tacrolimus Levels in African Americans Using GWAS
W. Oetting,¹ D. Schladt,² W. Guan,¹ A. Israni,² R. Remmel,¹ C. Dorr,² K. Sanghavi,¹ R. Mannon,³ B. Herrera,⁴ A. Matas,¹ D. Salomon,⁵ P. Kwok,⁴ P. Jacobson,¹ for DeKAF Genomics.¹
¹Univ. of Minnesota, Minneapolis; ²Minneapolis Medical Research Foundation, Minneapolis; ³Univ. of Alabama, Birmingham; ⁴Univ. of California, San Francisco; ⁵Scripps Research Center, La Jolla.
African American kidney transplant recipients (AA) have a higher incidence of allograft failure when compared to Caucasians. We have previously reported that tacrolimus troughs (TT)…