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American Transplant Congress abstracts

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Articles tagged "Polymorphism"

  • 2020 American Transplant Congress

    The FcγRIIIa-158 VV Genotype Increased the Risk of Post-Transplant Lymphoproliferative Disorder in T-Cell Depleted Kidney Transplant Recipients

    P. Gatault1, L. Lajoie1, J. Stojanova2, P. Marquet2, G. Thibault1

    1CHU Tours, Tours, France, 2CHU Limoges, Limoges, France

    *Purpose: Post-transplantation lymphoproliferative disorder (PTLD) is a severe complication in organ transplant recipients. The use of T lymphocyte-depleting antibodies (TLDAb), especially rabbit TLDAb contributes to…
  • 2020 American Transplant Congress

    Significance of Gene Polymorphism on Infectious Complications and Rejection after Liver Transplantation

    H. Egawa1, T. Kato1, Y. Kotera1, A. Ohmori1, G. Shibuya1, S. Yamashita1, S. Ariizumi1, M. Yamamoto1, T. Ishizuka2, Y. Tanaka3, H. Ohdan3

    1Tokyo Women's Medical University, Tokyo, Japan, 2Clinical Labotratory, Tokyo Women's Medical University, Tokyo, Japan, 3Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: Clinical application of gene polymorphism is a key of precision medicine in the field of organ transplantation. Infection and rejection are major factors affecting…
  • 2020 American Transplant Congress

    Precision Dosing for Tacrolimus Using Genotypes and Clinical Factors

    M. Al-Kofahi1, W. Oetting1, A. Israni2, D. Schladt3, W. Guan4, B. Wu4, C. Dorr5, R. Remmel6, R. Mannon7, N. Pankratz8, A. Matas9, P. Jacobson1

    1Experimental and Clinical Pharmacology, Univ of MN, College of Pharmacy, Minneapolis, MN, 2Nephrology, Univ of MN and Hennepin HealthCare, Minneapolis, MN, 3Hennepin HealthCare Research Institute, Hennepin HealthCare, Minneapolis, MN, 4Biostatistics, Univ of MN, Minneapolis, MN, 5Nephrology, Hennepin HealthCare, Minneapolis, MN, 6Medicinal Chemistry, Univ of MN, College of Pharmacy, Minneapolis, MN, 7Nephrology, Univ of Alabama, Minneapolis, MN, 8Lab Medicine Pathology, Univ of MN, Minneapolis, MN, 9Surgery, Univ of MN, Minneapolis, MN

    *Purpose: Variants in CYP3A4/5 genes, clinical factors and drug-drug interactions are associated with tacrolimus (TAC) clearance and dose. This results in high intra- and inter-…
  • 2020 American Transplant Congress

    Impact of PD1, PDL1 Gene Polymorphisms on Allo-Immune Responses after Kidney Transplantation

    H. Yamane, Y. Tanaka, M. Ohira, H. Tahara, K. Ide, H. Ohdan

    Hiroshima University, Hiroshima, Japan

    *Purpose: The programmed death (PD)-1/PD-1 ligands (PD-Ls) pathway, a member of the B7/CD28 family, triggers an immune checkpoint resulting in inhibition of T cells. Several…
  • 2018 American Transplant Congress

    Identification of Human SIRPa Diversity That Could Regulate Innate Allorecognition

    A. Friday,1 H. Dai,1 A. Williams,1 M. Oberbarnscheidt,1 J. Danska,2 F. Lakkis.1

    1Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 2Immunology and Medical Biophysics, University of Toronto, Toronto, ON, Canada.

    Innate allorecognition is a process by which myeloid cells, such as monocytes, distinguish syngeneic from allogeneic cells. Monocytes that recognize donor cells as non-self differentiate…
  • 2018 American Transplant Congress

    Glucocorticoid Receptor Polymorphism Affects Susceptibility of Dyslipidemia in Recipients One Year after Kidney Transplantation

    K. Numakura,1 H. Kagaya,2 N. Komine,1 R. Yamamoto,1 N. Fujiyama,3 H. Tsuruta,1 A. Maeno,1 M. Saito,1 S. Narita,4 T. Inoue,1 T. Niioka,2 M. Miura,2 T. Habuchi,1 S. Satoh.3

    1Urology, Akita University Graduate School of Medicine, Akita, Japan; 2Pharmacy, Akita University Hospital, Akita, Japan; 3Center for Kidney Disease and Transplantation, Akita University Hospital, Akita, Japan; 4Blood Purification, Akita University Hospital, Akita, Japan.

    Purpose. Dyslipidemia (DL) is a critical comorbidity after renal transplantation and can arise cardiovascular diseases. The relationship between developing of DL and glucocorticoid receptor (NR3C1)…
  • 2017 American Transplant Congress

    Donor SIRPa Polymorphism Modulates the Innate Immune Response to Allogeneic Grafts.

    H. Dai,1 A. Friday,1 K. Abou-Daya,1 A. Williams,1 M. Oberbarnscheidt,1 J. Danska,2 F. Lakkis.1

    1Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 2Hospital for Sick Children, University of Toronto, Toronto, ON, Canada

    Mice devoid of T, B, NK, and innate lymphoid cells distinguish between self and allogeneic non-self despite the absence of an adaptive immune system. When…
  • 2017 American Transplant Congress

    Impact of Cytokine Gene Polymorphism on Clinical Outcome of Renal Transplantation.

    I. Pérez-Flores,1 J. Santiago,2 A. Moreno Dela Higuera,1 N. Calvo,1 B. Rodriguez-Cubillo,1 E. Urcelay,2 A. Shabaka,1 M. Calvo,1 A. Sanchez-Fructuoso.1

    1Nephrologist, Hospital Clinico San Carlos, Madrid, Spain; 2UGC Immunology, Hospital Clinico San Carlos and Instituto de Investigación Sanitaria (IdISSC), Madrid, Spain

    Cytokine production is subject to genetic regulation, in such a way that gene polymorphisms at the level of promoter or coding regions can alter their…
  • 2017 American Transplant Congress

    CMV Infection in Renal Transplant Recipients: Incidence and Efficacy of Prophylaxis According to Cytokine Single Nucleotide Polymorphisms.

    I. Perez-Flores, M. Moreno De La Higuera, N. Calvo Romero, B. Rodriguez Cubillo, A. Shabaka, M. Calvo Arevalo, V. Lopez De La Manzanara, A. Sanchez-Fructuoso.

    Nephrology, Hospital Clínico San Carlos, Madrid, Spain

    Objectives: To evaluate the influence of single nucleotide polymorphisms (SNP)of IL10, TNFα, IFNγand IL18 in the incidence of CMV infection in renal transplant recipients. Methods:…
  • 2017 American Transplant Congress

    Noninvasive Renal Transplant Graft Monitoring in Single Institution Using Cell-Free DNA in Recipient Plasma via Insertion-Deletion Allele Polymorphism.

    Y. Goh,1 S. Ho,2 L. Raman,1 V. Anantharaman,3 T. Goh,3 S. Koay,2 H. Tiong.1

    1Urology, National University Hospital, Singapore, Singapore; 2Laboratory Medicine, National University Hospital, Singapore, Singapore; 3Nephrology, National University Hospital, Singapore, Singapore

    IntroductionThere is an unmet clinical need in renal transplantation towards early detection of donor organ damage. Serum creatinine(SCr) and biopsies are not ideal.Cell-free donor DNA(cfdDNA)…
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