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Articles tagged "Polyma virus"

  • 2016 American Transplant Congress

    BK Viremia Surveillance and Management in Simultaneous Pancreas-Kidney Transplants.

    S. Westphal, C. Miles.

    Internal Medicine, University of Nebraska Medical Center, Omaha, NE.

    BK virus nephropathy is an important cause of kidney allograft dysfunction, and the mainstay of management is reduction of immunosuppression. In recipients of multiorgan transplants,…
  • 2016 American Transplant Congress

    Urinary Virome in Human Kidney Transplants Reveals Multiple Virus Subtypes with Distinct Genome Polymorphisms.

    R. Ranjan,1 A. Rani,1 H. McGee,1 D. Brennan,2 P. Finn,1 D. Perkins.1,3

    1Medicine, University of Illinois, Chicago, IL; 2Division of Renal Diseases, Washington University School of Medicine, St. Louis, MO; 3Surgery, University of Illinois, Chicago, IL.

    Recent studies have established that human urine has its own unique microbiome, but little is known about the virome. The human virome is the collection…
  • 2016 American Transplant Congress

    Autologous BK-Specific T-Cell Lines in Kidney Transplant Recipients.

    C. Lamarche,1,2,3 O. Julie,1,3 C. Carli,1,3 J.-S. Delisle.1,2,3

    1Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada; 2Canadian National Transplant Research Program (CNTRP), Edmonton, Canada; 3ThéCell Network, Quebec, Canada.

    Background: More than 75% of the population has been exposed to BK polyomavirus and carries latent virus in the uroepithelium. Immunocompetent hosts are asymptomatic but…
  • 2016 American Transplant Congress

    Potential Biomarkers and Treatment for BK Virus Associated Nephropathy.

    M. Borkar,1 V. Srivastava,2 R. Cunnington,1 T. Sharma,1 L. Tibbles.1

    1Faculty of Mediicne, University of Calgary, Calgary, AB, Canada; 2CSIR-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India.

    Background: BK polyomavirus assoiciated nephropathy (BKVAN) is one of the major complications in renal transplants, and is associated with significant fibrosis It is important to…
  • 2016 American Transplant Congress

    Sequential and Long-Term Protocol Biopsy Is Useful for the Detection of Subclinical Lesions of Clinical Interest in Kidney Allografts.

    M. Miura,1 H. Higashiyama,1 T. Tsuji,2 Y. Fukasawa.2

    1Department of Urology and Renal Transplantation Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan; 2Department of Pathology, Sapporo City General Hospital, Sapporo, Japan.

    Objectives: Detection of subclinical lesions is important to overcome the obstacles to improve long-term graft survival after kidney transplantation. The aim of this study was…
  • 2016 American Transplant Congress

    25-Hydroxyvitamin D Insufficiency Is Associated with Higher Risk of BK Virus Re-Activation After Kidney Transplantation.

    N. Elfadawy,1 S. Flechner,2 E. Poggio,2 B. Stephany,2 R. Fatica,2 J. Schold,2 S. Mossad.2

    1Internal Medicine, Case Western Reserve University, Cleveland, OH; 2Cleveland Clinic, Cleveland, OH.

    BACKGROUND: The past decade has seen increased interest in vitamin D, as new data suggest that it plays a role in the immune system. The…
  • 2016 American Transplant Congress

    Evaluating Posttransplant BKV-Specific T Cell Responses in Patients with Alemtuzumab Induction and Belatacept-Based Regimen.

    M. McRae, T. How, A. Kirk, H. Xu.

    Department of Surgery, Duke University, Durham, NC.

    Belatacept-based maintenance regimens prevent acute allograft rejection following alemtuzumab induction, and patients so treated maintain intact anti-CMV and -EBV T cell immune responses without viral…
  • 2016 American Transplant Congress

    BK Polyomavirus Seroreactivity of Kidney Donors Predicts Viremia and Nephropathy in Recipients.

    H. Wunderink,1 E. van der Meijden,1 C. van der Blij-de Brouwer,1 M. Mallat,2 G. Haasnoot,3 E. van Zwet,4 E. Claas,1 J. de Fijter,3 A. Kroes,1 F. Arnold,5 A. Touzé,5 F. Claas,3 J. Rotmans,3 M. Feltkamp.1

    1Medical Microbiology, LUMC, Leiden, Netherlands; 2Nephrology, LUMC, Leiden, Netherlands; 3Immunohematology and Blood Transfusion, LUMC, Leiden, Netherlands; 4Medical Statistics and Bioinformatics, LUMC, Leiden, Netherlands; 5UMR INRA 1282 ISP, Université François Rabelais, Tours, France.

    Background Kidney transplant (KTx) donors are not implicated in predicting BK polyomavirus (BKV) infection in the recipient. For BKV-associated nephropathy (BKVAN) however, donor origin of…
  • 2016 American Transplant Congress

    Incidence and Factors Associated with De Novo DSA After BK Viremia in Renal Transplant Recipients.

    S. Patel, S. Kuten, R. Knight, D. Nguyen, E. Graviss, A. Gaber.

    Houston Methodist Hospital, Houston, TX.

    Recent literature indicates an elevated rate of de novo DSA (dnDSA) following BK viremia (BKV) in renal transplant recipients (RTR). We sought to review our…
  • 2016 American Transplant Congress

    Immune Response to BK Virus in Renal Transplant Recipients.

    D. DeWolfe,1 J. Gandhi,1 M. Mackenzie,1 T. Broge,1 E. Bord,1 D. Mandelbrot,1 R. Viscidi,2 F. Cardarelli,1 M. Pavlakis,1 C. Tan.1

    1Medicine, Beth Israel Deaconess Medical Center, Boston, MA; 2Pediatrics, Johns Hopkins Medical Center, Baltimore, MD.

    Background: The adaptive immune characteristics associated with BK Virus (BKV) infection and control remain incompletely described. In this study we further elucidate the immune response…
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