Articles tagged "Polyma virus"

2020 American Transplant Congress
Incidence and Risks Factors of Kidney Allograft Loss Due to BK Virus in Pediatric Population: UNOS Data Set
H. Patel¹, K. Agrawal¹, A. Pawar¹, N. Rodig², N. Agrawal¹, F. Cardarelli¹
¹Transplant Nephrology, Beth Israel Deaconess Medical Center, Boston, MA, ²Nephrology (Medicine), Boston Children's Hospital, Boston, MA
*Purpose: BK virus infection can lead to graft dysfunction and loss in kidney transplant patients. Incidence and prevalence of BK Viremia (BKV) and BK Virus…
2020 American Transplant Congress
Risk Factors for BK Virus Infection after Kidney Transplantation in the Contemporary Era: A Single-Centre Observational Study
N. Phagura¹, K. Thandi¹, F. Evison², S. Gallier², A. Sharif³
¹College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, ²Department of Health Informatics, University Hospitals Birmingham, Birmingham, United Kingdom, ³Department of Nephrology and Transplantation, University Hospitals Birmingham, Birmingham, United Kingdom
*Purpose: BK infection remains a risk factor for kidney transplant dysfunction and allograft loss. While many risk factors are reported in the literature, many are…
2020 American Transplant Congress
Development of Self-Limited Low-Level BK Viremia/Viruria Suggests Ideal Immunosuppression to Suppress T-Cell and Antibody-Mediated Rejection and to Preserve Kidney Allograft Function
B. Näf, T. Müller, R. Wüthrich, T. Schachtner
University Hospital Zurich, Zurich, Switzerland
*Purpose: Polyomavirus BK (BKV) has been suggested as a surrogate marker of overimmunosuppression. Due to recent advances in monitoring strategies and pre-emptive therapy, progression to…
2020 American Transplant Congress
Everolimus for BKV Nephropathy in Kidney Transplant Recipients: A Prospective, Controlled Study
E. Bussalino¹, D. Bellino¹, L. Marsano¹, F. Massarino¹, R. Russo¹, I. Fontana², G. Zaza³, G. Stallone⁴, E. Paoletti¹
¹Nephrology, Dialysis, and Transplantation, Policlinico San Martino Genova, Genova, Italy, ²Transplantation Unit, Policlinico San Martino Genova, Genova, Italy, ³Renal Unit, Department of Medicine,, University Hospital of Verona, Verona, Italy, ⁴Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy
*Purpose: Polyoma BK virus nephropathy (BKVN) of KTRs is associated with adverse outcome, since no specific therapy exists. EVR showed promising antiviral effects but systematic…
2020 American Transplant Congress
The Noninvasive Urinary Sediment Double Immunostaining Test Predicts BK Polyomavirus Nephropathy in Kidney Transplant Recipients
G. Huang¹, X. Chen¹, S. Yang¹, X. Hou², H. Yang³, C. Wang¹
¹The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Guangzhou KingMed Center for Clinical Laboratory Co, Ltd, Guangzhou, China, ³Fuda Cancer Hospital, Jinan University, Fuda Cancer Hospital, Guangzhou, China
*Purpose: This study aimed to improve the diagnostic value of decoy cells for BK polyomavirus associated-nephropathy (BKPyVAN) in kidney transplant recipients.*Methods: A total of 105…
2020 American Transplant Congress
Impact of Depleting Induction Agents on BK Virus and Polyomavirus Associated Nephropathy
J. Clark¹, A. Barlow¹, A. Haririan²
¹University of Maryland Medical Center, Baltimore, MD, ²University of Maryland School of Medicine, Baltimore, MD
*Purpose: Polyomavirus associated nephropathy (PVAN) is an opportunistic infection associated with graft loss and rejection. Due to limited treatment options, identifying kidney transplant recipients at…
2020 American Transplant Congress
Longitudinal Study Investigating Characteristics of Human Polyimaviruses Infection after Kidney Transplantation
E. Favi¹, S. Delbue², C. Colico¹, L. Signorini², L. Clementoni¹, M. Ferraresso¹
¹Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, ²Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy
*Purpose: Human Polyomaviruses (HPyV) infections are extremely common, ranging from 60% to 100% in the general population, depending on the virus. After primary infection, which…
2020 American Transplant Congress
Urine Donor Derived Cell Free DNA Aids in the Diagnosis of BK Polyomavirus Nephropathy in Kidney Transplant Recipients with BK Viruria
G. Huang¹, X. Chen¹, W. Chen¹, P. Chen¹, T. Jiang², C. Wang¹, L. Chen¹
¹The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²AlloDx Biotech Co., Ltd, Suzhou, China
*Purpose: BK polyomavirus nephropathy (BKVN) are important cause of dysfunction and failure of renal transplants, which is similar to T cell mediated rejection (TCMR) in…
2020 American Transplant Congress
Pathological Characteristics of BK Polyomavirus Nephropathy with Glomerular Involvement
G. Huang¹, X. Chen¹, W. Chen², S. Yang², J. Qiu¹
¹Department of Organ Transplantation, 1st Affiliated Hospital, Zhongshan University, Guangzhou, China, ²Department of Pathology, 1st Affiliated Hospital, Zhongshan University, Guangzhou, China
*Purpose: This study aimed to investigate the pathological characteristics of BK polyomavirus-associated nephropathy with glomerular involvement in kidney transplant recipients.*Methods: Forty-four patients with glomerular BK…
2020 American Transplant Congress
Experience with a BKV-Specific, Neutralizing Monoclonal Antibody (MAU868) for Treatment of Severe BK Virus Nephropathy (BKVN) after Kidney Transplant (FDA EIND #139112)
S. C. Jordan¹, S. J. Kovacs², J. R. Abend³, N. Ammerman¹, M. Toyoda¹, C. C. Nast¹, E. Huang¹, R. Najjar¹, S. Sethi¹, A. Peng¹, K. Lim¹, M. R. Hodges⁴, A. Vo¹
¹Cedars Sinai Medical Ctr, Los Angeles, CA, ²Novartis Institutes for BioMedical Research, East Hanover, NJ, ³Novartis Institutes for BioMedical Research, Emeryville, CA, ⁴Amplyx Pharmaceuticals, San Diego, CA
*Purpose: BK viral reactivation leading to nephropathy and allograft loss in kidney transplant recipients remains a significant challenge. No effective BKV-therapies are currently available. Management…