Articles tagged "Polyma virus"

2022 American Transplant Congress
Concordance of POLQ and PARP-1 Expression and MMEJ Type Viral Integration in the Progression of BKPyV-Associated Diseases
Y. Wang¹, Z. Yan¹, Y. Liu², J. Geng³, W. Deng¹, R. Xia¹, W. Zeng¹, J. Xu¹, C. Wu⁴, Y. Miao¹
¹Department of Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China, ³Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁴Departments of Urology & Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: To reveal the mechanism of the increasing dominant position of integration, especially the microhomology-mediated end joint (MMEJ) form in the development of BK Polyomavirus…
2022 American Transplant Congress
BK Polyomavirus Infection is Not Associated with a Meaningful Increase in Donor-Derived Cell-Free DNA
J. Fisher¹, K. Vieira¹, R. Burke², R. Gohh¹, R. Rogers¹
¹Warren Alpert Medical School of Brown University, Providence, RI, ²CareDx, Brisbane, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a non-invasive measure of early allograft injury that has been clinically validated as a surveillance tool to detect antibody…
2022 American Transplant Congress
Kinetic Analysis of Post-Clearance Phase Inflammation in Kidney Biopsies After BK Viremia
M. Vincent¹, J. T. Rajagopal¹, E. Farkash²
¹University of Michigan, Ann Arbor, MI, ²Dept. of Pathology, University of Michigan, Ann Arbor, MI
*Purpose: During the post-clearance phase of BK polyomavirus nephropathy, tubulointerstitial inflammation can persist despite resolution of BK viremia. This inflammation is indistinguishable from low grade…
2022 American Transplant Congress
Dd-cfdna Correlates With Acute Rejection In The Setting Of Bk Viremia After Kidney Transplantation
N. M. Ali¹, J. Miles², V. Tatapudi¹, R. Chand¹, R. Montgomery¹
¹NYU Langone Transplant Institute, New York, NY, ²CareDx, Brooklyn, NY
*Purpose: BK virus reactivation is common among kidney transplant recipients (KTRs) and is a risk factor for allograft loss. Currently, there is no clearly established…
2022 American Transplant Congress
BK Polyomavirus and Cytomegalovirus Infections in Kidney Transplantation from Hepatitis C Positive Donors to Uninfected Recipients
I. Yakubu, V. Amrutiya, I. Moinuddin, M. Levy, G. Gupta, A. Azhar
Virginia Commonwealth University, Richmond, VA
*Purpose: Transplantation of hepatitis C viremic (HCV) donor kidneys into uninfected recipients (D+/R-) is becoming more common in the United States. However, the long-term risks…
2022 American Transplant Congress
Posoleucel as Preemptive Therapy for BKV Infection in Kidney Transplant Recipients: Safety and Tolerability in a Phase 2 Trial
R. K. Wali¹, M. Singh², D. Wojciechowski³, M. J. Ansari⁴, B. Lonze⁵, V. Nair⁶, A. Sharma⁷, S. Knechtle⁸, F. Cardarelli⁹, A. Chandraker¹⁰
¹Inova Transplant Center, Falls Church, VA, ²U. of Pittsburg Medical Center, Harrisburg, PA, ³UT Southwestern Medical Center, Dallas, TX, ⁴Northwestern U. Feinberg School of Medicine, Chicago, IL, ⁵NYU Langone Transplant Institute, New York, NY, ⁶Northwell Health, Manhasset, NY, ⁷U. of Pittsburgh Medical Center, Pittsburgh, PA, ⁸Duke U. School of Medicine, Durham, NC, ⁹AlloVir, Cambridge, MA, ¹⁰Brigham & Women's Hospital, Boston, MA
*Purpose: Kidney transplant (KT) recipients with BK viremia are at risk for BK virus (BKV) nephropathy and graft loss. There are no approved therapies for…
2022 American Transplant Congress
Early Tacrolimus Exposure is Associated with BK-Viremia in Kidney Transplant Recipients
S. Meziyerh, A. L. van Rijn, D. van der Helm, P. J. van der Boog, T. van Gelder, A. C. Kroes, J. W. de Fijter, D. J. Moes, J. I. Rotmans, M. C. Feltkamp, A. P. de Vries
LUMC, Leiden, Netherlands
*Purpose: There is scant evidence to what extent maintenance immunosuppression is quantitatively associated with BK viremia. We investigated the association between tacrolimus (tac) whole blood…
2022 American Transplant Congress
RBBP7 as a Novel Biomarker for the Molecular Diagnosis of BK Virus-Associated Nephropathy
W. Yicun, W. Yuxuan, H. Xiaopeng
Department of Urology, Beijing Chaoyang Hospital, Beijing, China
*Purpose: BK virus-associated nephropathy (BKVN) remains a major infectious complication of kidney transplantation, and its histologic appearance can mimic rejection, leading to a diagnostic dilemma…
2022 American Transplant Congress
Clinical Relevance of Absolute BK Polyoma Viral Load Kinetics in Patients with Biopsy Proven BK Polyomavirus Associated Nephropathy
H. Omic¹, J. P. Kläger¹, H. Herkner¹, S. W. Aberle¹, H. Regele¹, L. Weseslindtner¹, T. A. Schrag¹, G. Bond¹, K. Hohenstein¹, B. Watschinger¹, J. Werzowa², R. Strassl¹, M. Eder¹, Z. Kikic¹
¹Medical University of Vienna, Vienna, Austria, ²Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria
*Purpose: The absolute BK viral load is an important diagnostic surrogate for BK polyomavirus associated nephropathy (PyVAN) after renal transplant (KTX) and serial assessment of…
2022 American Transplant Congress
De-Novo Belatacept Therapy is Associated with Higher Levels of BK Viremia and Lower Rates of BK Clearance in Kidney Transplantation Patients
G. Petrossian¹, J. Ortiz², K. Addonizio¹, L. Teixeira¹, A. Hsiao¹, R. James³, N. Koizumi³, S. Patel⁴, D. Conti², R. Plews²
¹Albany Medical Center, Albany, NY, ²Division of Renal and Pancreatic Transplant Services, Albany Medical Center, Albany, NY, ³George Mason University, Fairfax, VA, ⁴UMC Las Vegas, Las Vegas, NV
*Purpose: To compare the incidence and severity of BK viremia in kidney transplantation patients with a de-novo belatacept (bela) vs. a no-bela maintenance immunosuppression regimen.*Methods:…

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