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American Transplant Congress abstracts

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Articles tagged "Polyma virus"

  • 2020 American Transplant Congress

    Incidence and Risks Factors of Kidney Allograft Loss Due to BK Virus in Pediatric Population: UNOS Data Set

    H. Patel1, K. Agrawal1, A. Pawar1, N. Rodig2, N. Agrawal1, F. Cardarelli1

    1Transplant Nephrology, Beth Israel Deaconess Medical Center, Boston, MA, 2Nephrology (Medicine), Boston Children's Hospital, Boston, MA

    *Purpose: BK virus infection can lead to graft dysfunction and loss in kidney transplant patients. Incidence and prevalence of BK Viremia (BKV) and BK Virus…
  • 2020 American Transplant Congress

    Risk Factors for BK Virus Infection after Kidney Transplantation in the Contemporary Era: A Single-Centre Observational Study

    N. Phagura1, K. Thandi1, F. Evison2, S. Gallier2, A. Sharif3

    1College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, 2Department of Health Informatics, University Hospitals Birmingham, Birmingham, United Kingdom, 3Department of Nephrology and Transplantation, University Hospitals Birmingham, Birmingham, United Kingdom

    *Purpose: BK infection remains a risk factor for kidney transplant dysfunction and allograft loss. While many risk factors are reported in the literature, many are…
  • 2020 American Transplant Congress

    Development of Self-Limited Low-Level BK Viremia/Viruria Suggests Ideal Immunosuppression to Suppress T-Cell and Antibody-Mediated Rejection and to Preserve Kidney Allograft Function

    B. Näf, T. Müller, R. Wüthrich, T. Schachtner

    University Hospital Zurich, Zurich, Switzerland

    *Purpose: Polyomavirus BK (BKV) has been suggested as a surrogate marker of overimmunosuppression. Due to recent advances in monitoring strategies and pre-emptive therapy, progression to…
  • 2020 American Transplant Congress

    Everolimus for BKV Nephropathy in Kidney Transplant Recipients: A Prospective, Controlled Study

    E. Bussalino1, D. Bellino1, L. Marsano1, F. Massarino1, R. Russo1, I. Fontana2, G. Zaza3, G. Stallone4, E. Paoletti1

    1Nephrology, Dialysis, and Transplantation, Policlinico San Martino Genova, Genova, Italy, 2Transplantation Unit, Policlinico San Martino Genova, Genova, Italy, 3Renal Unit, Department of Medicine,, University Hospital of Verona, Verona, Italy, 4Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy

    *Purpose: Polyoma BK virus nephropathy (BKVN) of KTRs is associated with adverse outcome, since no specific therapy exists. EVR showed promising antiviral effects but systematic…
  • 2020 American Transplant Congress

    The Noninvasive Urinary Sediment Double Immunostaining Test Predicts BK Polyomavirus Nephropathy in Kidney Transplant Recipients

    G. Huang1, X. Chen1, S. Yang1, X. Hou2, H. Yang3, C. Wang1

    1The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2Guangzhou KingMed Center for Clinical Laboratory Co, Ltd, Guangzhou, China, 3Fuda Cancer Hospital, Jinan University, Fuda Cancer Hospital, Guangzhou, China

    *Purpose: This study aimed to improve the diagnostic value of decoy cells for BK polyomavirus associated-nephropathy (BKPyVAN) in kidney transplant recipients.*Methods: A total of 105…
  • 2020 American Transplant Congress

    Impact of Depleting Induction Agents on BK Virus and Polyomavirus Associated Nephropathy

    J. Clark1, A. Barlow1, A. Haririan2

    1University of Maryland Medical Center, Baltimore, MD, 2University of Maryland School of Medicine, Baltimore, MD

    *Purpose: Polyomavirus associated nephropathy (PVAN) is an opportunistic infection associated with graft loss and rejection. Due to limited treatment options, identifying kidney transplant recipients at…
  • 2020 American Transplant Congress

    Longitudinal Study Investigating Characteristics of Human Polyimaviruses Infection after Kidney Transplantation

    E. Favi1, S. Delbue2, C. Colico1, L. Signorini2, L. Clementoni1, M. Ferraresso1

    1Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, 2Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy

    *Purpose: Human Polyomaviruses (HPyV) infections are extremely common, ranging from 60% to 100% in the general population, depending on the virus. After primary infection, which…
  • 2020 American Transplant Congress

    Urine Donor Derived Cell Free DNA Aids in the Diagnosis of BK Polyomavirus Nephropathy in Kidney Transplant Recipients with BK Viruria

    G. Huang1, X. Chen1, W. Chen1, P. Chen1, T. Jiang2, C. Wang1, L. Chen1

    1The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2AlloDx Biotech Co., Ltd, Suzhou, China

    *Purpose: BK polyomavirus nephropathy (BKVN) are important cause of dysfunction and failure of renal transplants, which is similar to T cell mediated rejection (TCMR) in…
  • 2020 American Transplant Congress

    Pathological Characteristics of BK Polyomavirus Nephropathy with Glomerular Involvement

    G. Huang1, X. Chen1, W. Chen2, S. Yang2, J. Qiu1

    1Department of Organ Transplantation, 1st Affiliated Hospital, Zhongshan University, Guangzhou, China, 2Department of Pathology, 1st Affiliated Hospital, Zhongshan University, Guangzhou, China

    *Purpose: This study aimed to investigate the pathological characteristics of BK polyomavirus-associated nephropathy with glomerular involvement in kidney transplant recipients.*Methods: Forty-four patients with glomerular BK…
  • 2020 American Transplant Congress

    Experience with a BKV-Specific, Neutralizing Monoclonal Antibody (MAU868) for Treatment of Severe BK Virus Nephropathy (BKVN) after Kidney Transplant (FDA EIND #139112)

    S. C. Jordan1, S. J. Kovacs2, J. R. Abend3, N. Ammerman1, M. Toyoda1, C. C. Nast1, E. Huang1, R. Najjar1, S. Sethi1, A. Peng1, K. Lim1, M. R. Hodges4, A. Vo1

    1Cedars Sinai Medical Ctr, Los Angeles, CA, 2Novartis Institutes for BioMedical Research, East Hanover, NJ, 3Novartis Institutes for BioMedical Research, Emeryville, CA, 4Amplyx Pharmaceuticals, San Diego, CA

    *Purpose: BK viral reactivation leading to nephropathy and allograft loss in kidney transplant recipients remains a significant challenge. No effective BKV-therapies are currently available. Management…
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