Articles tagged "Polyma virus"

2016 American Transplant Congress
Neutrophil-to-Lymphocyte Ratio as a Predictor of Polyomavirus BK Nephropathy in Kidney Transplant Patients.
K. Masutani,¹ A. Tsuchimoto,¹ Y. Matsukuma,¹ K. Kaku,² K. Kurihara,² Y. Okabe,² K. Tsuruya,¹ M. Nakamura,² T. Kitazono.¹
¹Department of Medicine and Clinical Science, Kyushu University, Fukuoka, Japan; ²Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan.
Background: Neutrophil-to-lymphocyte ratio (NLR) is an index for systemic inflammatory response, and has been reported to be a prognostic marker in the patients with malignancies…
2016 American Transplant Congress
Potential Applications of Viral miRNA Assays in the Management of Transplant Patients with Polyomavirus BK Infection.
P. Randhawa, G. Zeng, Y. Huang.
Department of Pathology, The Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA.
Background: BKV encodes two miRNAs from a single precursor: BKV-miR-B1-5p & BKV-JCV-miR-BJ1-3p. These viral miRNAs direct cleavage of large T antigen mRNAs, downregulate viral T…
2016 American Transplant Congress
Impact of BKV Subtype Distribution on BKV Nephropathy, Viremia, and Renal Outcome in Patients After Renal Transplantation.
S. Anke,¹ L. Silvia,¹ H. Hermann,¹ H. Albert,² S. Corinna.²
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Virology, Hannover Medical School, Hannover, Germany.
Factors determining the course of BK viral (BKV) infection remain uncertain. We studied the role of BKV subtype distribution in BKV-infected patients after renal transplantation.-We…
2016 American Transplant Congress
HLA Class II and BK Virus Reactivation in Renal Transplant Recipients.
P. Shah,¹ K. Anderson,² M. Aubrey,² C. Roark,² B. Freed,² A. Wiseman.¹
¹Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, CO; ²Division of Immunology, University of Colorado School of Medicine, Aurora, CO.
BK Viremia (BKV) and subsequent BK nephropathy are associated with renal graft loss. The Human Leukocyte Antigen (HLA) region has been implicated in susceptibility to…
2016 American Transplant Congress
Increased Gene Expression of TGF-β in Peripheral Blood Mononuclear Cells from Renal Transplant Patients with Polyomavirus BK Viremi.
W. Yin,¹ M. Lu.²
¹Surgery, School of Medicine, Tzu Chi University, Hualien, Taiwan, Division of General Surgery, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-I, Dalin, Taiwan; ²Allergy, Immunology and Rheumatology, School of Medicine, Tzu Chi University, Hualien, Taiwan, Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-I, Dalin, Taiwan.
We aimed to investigate the roles of cytokines during polyomavirus BK (BKV) reactivation in renal transplant patients. Forty-eight renal allograft recipients were enrolled in this…
2016 American Transplant Congress
Simultaneous Pancreas/Kidney Transplantation Increases the Risk of Late-Onset BKV-Associated Nephropathy.
T. Schachtner,^1,2 M. Zaks,¹ A. Kahl,¹ P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany.
Infections have increased in simultaneous pancreas/kidney transplant recipients (SPKTRs) with BKV-associated nephropathy (BKVN) being the most important infectious cause of allograft loss. Comparisons of BKVN…
2016 American Transplant Congress
New England BK Consortium: Regional Survey of BK Screening and Management Protocols in Comparison to Published Consensus Guidelines.
S. Gabardi, M. Pavlakis, C. Tan, J. Francis, F. Cardarelli, W. Asch, K. Bodziak, M. Chobanian, H. Gilligan, R. Gohh, S. Kung, L. Inker, S. Martin, N. Rodig, A. Rossi, A. Chandraker.
New England BK Consortium, Boston, MA.
Introduction: BK virus (BKV) continues to impact renal transplant recipients (RTR). The New England BK Consortium was formed to unite the leadership of 14 transplant…
2016 American Transplant Congress
Results of a Biopsy Based, Early Intervention Treatment Protocols for BK Viraemia and BK Virus Associated Nephropathy.
S. Jones,¹ S. Waller,¹ K. Lai,^2,3 A. Hibbard,¹ P. Trevillian,¹ M. Heer.¹
¹Newcastle Transplant Unit, John Hunter Hospital, Newcastle, NSW, Australia; ²Infectious Diseases and Immunology Department, John Hunter Hospital, Newcastle, NSW, Australia; ³University of Newcastle, Newcastle, NSW, Australia.
Background: Following the death of a renal transplant recipient (RTR) in 2003 following BK Virus associated nephropathy (BKVAN) and acute rejection, our centre adopted protocols…
2016 American Transplant Congress
Evaluation of Polyomavirus (BK) Treatment and Clinical Outcomes in Pediatric Kidney Transplant Recipients: A >10 Year Single Center Retrospective Experience.
R. Liverman,¹ E. Kraus,¹ R. Garro,² B. Warshaw,² P. Winterberg,² R. George.²
¹Children's Healthcare of Atlanta, Atlanta, GA; ²Division of Pediatric Nephrology, Emory University School of Medicine, Atlanta, GA.
BK viremia (BKV) is a serious infectious complication after kidney transplantation and can lead to BK nephropathy (BKN) and allograft loss. We reviewed our experience…
2016 American Transplant Congress
Incidence of Polyoma Virus Associated Nephropathy in a Single Transplant Center Employing a Reduction of Immunosuppression at a Lower Threshold of BK Viremia.
M. Azar, A. Valika, D. Banach, I. Hall, M. Malinis.
Internal Medicine, Infectious Diseases, Yale University, New Haven, CT.
BackgroundPolyoma virus associated nephropathy (PyVAN) caused by BK virus (BKV) is a major complication occurring in 1-10% of renal transplant recipients. Screening and reduction of…