Articles tagged "Polyma virus"

2017 American Transplant Congress
Poor Outcome of Polyomavirus -Associated Nephropathy with Glomerular Parietal Epithelial Cells Infected by Polyomavirus.
G. Huang,¹ W. Chen,² J. Qiu,¹ X. Chen,¹ L. Chen,¹ C. Wang.¹
¹Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; ²Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Background: Bowman's capsular epithelium infected by polyomavirus(Py) in polyomavirus -associated nephropathy (PyVAN) is infrequent and considered as the advanced stage of the disease. The aim…
2017 American Transplant Congress
Resumption of Standard Dose Immunosuppression Following Resolution of BK Viremia Does Not Lead to Viremia Recurrence.
K. Alquadan, A. Santos, M. Casey, T. Ozrazgat-Baslanti, S. Bozorgmehri, J. Gregg, K. Womer.
Medicine, Nephrology, University of Florida, Gainesville, FL
Introduction: Reduction of immunosuppression (IS) in response to BK viremia following kidney transplantation prevents the development of BK virus nephropathy, with no apparent increase in…
2017 American Transplant Congress
Defining a BKV Cutt-Off and Profile for Early Detection of BKV Associated Nephropathy.
C. Nihei,¹ F. Agena,¹ F. Paula,¹ D. David,¹ M. Fink,³ L. Pierrotti,² E. David-Neto.¹
¹Renal Transplantation Service, Universidade de São Paulo, São Paulo, SP, Brazil; ²Parasitic and Infectious Diseases Division, Universidade de São Paulo, São Paulo, SP, Brazil; ³Tropical Medicine Institute, Universidade de São Paulo, São Paulo, SP, Brazil
BK polyomavirus-associated nephropathy (BKPyVAN) represents a challenge to transplant centers. Prevention using early detection of BKPy viremia (BKPyV) and immunosuppression(IS) reduction is the best current…
2017 American Transplant Congress
Calibration of BK Virus Nucleic Acid Amplification Testing to the 1^st WHO International Standard for BK Virus.
S. Tan,¹ S. Milligan,² M. Sahoo,³ N. Taylor,² B. Pinsky.^1,2,3
¹Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA; ²Clinical Virology Laboratory, Stanford Health Care, Stanford, CA; ³Department of Pathology, Stanford University School of Medicine, Stanford, CA
Significant inter-assay variability in the quantification of BK virus (BKV) DNA has limited the broad applicability of thresholds for the management of BKV infection in…
2017 American Transplant Congress
Does Histologic Grade in BK Polyoma Nephropathy Associate with Viral Load, Allograft Dysfunction or Allograft Loss? A Single Center Experience.
M. Swee,¹ S. Kuppachi,¹ M. Fraer,¹ P. Rastogi,² P. Ten Eyck,¹ M. Sanders.¹
¹Nephrology, University of Iowa, Iowa City, IA; ²Pathology, University of Iowa, Iowa City, IA
Purpose: BK polyoma nephropathy (BKPyN) is a well-recognized cause of allograft dysfunction and loss after kidney transplant. Despite increased recognition, it is unclear if changes…
2017 American Transplant Congress
Repeat Biopsies After the Diagnosis of BK Virus Associated Nephropathy: Importance of Integrating Clinical and Pathological Findings.
C. Drachenberg,¹ J. Papadimitriou,¹ R. Ugarte,² M. Mavanur,² B. Thomas,² C. Cangro,² N. Costa,² M. Weir,² A. Haririan.²
¹Pathology, University of Maryland School of Medicine, Baltimore, MD; ²Medicine, University of Maryland School of Medicine, Baltimore, MD
Early diagnosis of PV nephropathy(PyVAN) leads to overall improvements in the short term but sclerosing sequelae and risk for rejection (mainly antibody mediated) contribute to…
2017 American Transplant Congress
Treatment and Outcomes of Simultaneous Acute Rejection and Polyomavirus Allograft Nephropathy.
T. Sparkes, S. Hammad, C. Drachenberg, A. Haririan.
University of Maryland, Baltimore, MD
Background: Reduction of immunosuppression for polyomavirus allograft nephropathy (PVAN) is associated with risk of acute rejection (AR), and in uncommon cases both are present together…
2016 American Transplant Congress
Urinary Virome in Human Kidney Transplants Reveals Multiple Virus Subtypes with Distinct Genome Polymorphisms.
R. Ranjan,¹ A. Rani,¹ H. McGee,¹ D. Brennan,² P. Finn,¹ D. Perkins.^1,3
¹Medicine, University of Illinois, Chicago, IL; ²Division of Renal Diseases, Washington University School of Medicine, St. Louis, MO; ³Surgery, University of Illinois, Chicago, IL.
Recent studies have established that human urine has its own unique microbiome, but little is known about the virome. The human virome is the collection…
2016 American Transplant Congress
Autologous BK-Specific T-Cell Lines in Kidney Transplant Recipients.
C. Lamarche,^1,2,3 O. Julie,^1,3 C. Carli,^1,3 J.-S. Delisle.^1,2,3
¹Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada; ²Canadian National Transplant Research Program (CNTRP), Edmonton, Canada; ³ThéCell Network, Quebec, Canada.
Background: More than 75% of the population has been exposed to BK polyomavirus and carries latent virus in the uroepithelium. Immunocompetent hosts are asymptomatic but…
2016 American Transplant Congress
Potential Biomarkers and Treatment for BK Virus Associated Nephropathy.
M. Borkar,¹ V. Srivastava,² R. Cunnington,¹ T. Sharma,¹ L. Tibbles.¹
¹Faculty of Mediicne, University of Calgary, Calgary, AB, Canada; ²CSIR-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India.
Background: BK polyomavirus assoiciated nephropathy (BKVAN) is one of the major complications in renal transplants, and is associated with significant fibrosis It is important to…