2017 American Transplant Congress
Role of Chemokines in Resolution of BK Virus-Associated Nephropathy and Chronicity of Pathology Changes in Kidney Transplant Recipients.
David Geffen School of Medicine at UCLA, Los Angeles, CA
BK virus-associated nephropathy (BKN) remains the most common infectious cause of allograft loss after kidney transplantation. We previously demonstrated increased frequency of polyfunctional T cells…2017 American Transplant Congress
Nephrectomy of the Failed First Kidney Allograft Predisposes Kidney Transplant Recipients to Presensitization with Alloreactive T-Cells and Inferior Allograft Survival After Retransplantation.
During the last two decades the number of recipients (KTRs) of a previous kidney transplantation being evaluated and waitlisted for a subsequent kidney transplantation has…2017 American Transplant Congress
Improvement in Inflammatory Response Follows Clearance of BKVN.
Intro: Development of BKV nephropathy (BKVN) is a significant risk factor for graft loss. Proximate cause of graft loss is commonly attributed to acute/chronic rejection…2017 American Transplant Congress
Donor Derived and BK Virus Positive Urologic Cancers After Renal Transplantation.
Background. Donor-derived tumours in organ recipients develop from donor tissue with no known pre-existing malignancy in the donor. In addition, polyoma BK virus (BKV) might…2017 American Transplant Congress
Clinical Utility of Viral miRNA in Urinary Exosomes to Diagnose BK Virus Nephropathy After Kidney Transplantation.
Polymerase chain reaction (PCR) demonstration of BK viral replication in plasma and urine supports the diagnosis of BK virus nephropathy (BKVN), an important cause of…2017 American Transplant Congress
De Novo DSA Positivity Is Associated with a Higher Rate of Post-Transplant Bacterial and Viral Infections.
Background: BK viremia has been shown to correlate with de novo anti-HLA DSA (dnDSA) in renal transplant patients. However, it is unknown if and how…2017 American Transplant Congress
The Search for a Polyomavirus BK Nephropathy (BKPyVN)-Specific Transcriptomic Signature.
Recent work suggests that genes related to DNA replication signaling, RNA polymerase assembly, & pathogen recognition receptors are biomarkers for BKPyVN (Sigdel et al. Transplant…2016 American Transplant Congress
Incidence and Factors Associated with De Novo DSA After BK Viremia in Renal Transplant Recipients.
Houston Methodist Hospital, Houston, TX.
Recent literature indicates an elevated rate of de novo DSA (dnDSA) following BK viremia (BKV) in renal transplant recipients (RTR). We sought to review our…2016 American Transplant Congress
Immune Response to BK Virus in Renal Transplant Recipients.
Background: The adaptive immune characteristics associated with BK Virus (BKV) infection and control remain incompletely described. In this study we further elucidate the immune response…2016 American Transplant Congress
Identification of Donor HLA-Specific Antibodies as a Risk Factor for Graft Dysfunction and Failure Following BK Virus Associated Nephropathy.
Transplantation Medicine, Weill Cornell Medicine, New York, NY.
Background: BK virus associated nephropathy (BKVN) has emerged as a significant cause of graft dysfunction and graft failure. Identification of risk factors for graft dysfunction…
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