Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall D1
The WHO agency for cancer research has classified BKV as "possibly carcinogenic".The etiological role of BKV in human cancer, however,remains controversial.We present 5 cases of malignancies in Solid Organ Transplant recipients in association with BKV
The clinical characteristics and histology/immunohistochemistry(IHC) of tumors was studied by a chart review of 5 SOTR with renourinary tract tumors and +SV40 IHC and/or BK viremia
|Age at diagnosis||Organ/Transplant
|Year of diagnosis of BKV (Yrs posttransplant)||Year of diagnosis of cancer (Yrs posttransplant)||Location/Invasion||SV40||Histology|
|1||47 M||Heart 1998
|2012(14)||2015(17)||Bladder/pT1||+||Adenocarcinoma,micro papillary variant|
|2||57 M||Kidney 2003||2011(8)||2016(13)||Transplant kidney/pT3a||+||Poorly differentiated carcinoma|
|3||58 M||Lung 2008||2015(7)||Bladder/pT2||+||Urothelial: Small tubular pattern, plasmacytoid|
|4||72 M||Heart 1993||2007 (14)
|Bladder/pT1 at diagnosis
|+(LN)||Micropapillary variant GATA-3/CK7+|
|5||47 M||SPK 2008||2011(3)||2016(8)||Bladder
|Ureter urothelial ca, high grade
Bladder urothelial ca in situ
All patients were male with mean age of 56.6 years and 2 were dual organ transplants.3 SOTRs received induction with ATG. The mean time to diagnosis of cancer from transplant was 11.8 years. All Renal transplant recipients had BKV for a mean duration of 4.3 years prior to diagnosis of cancer.4 tumors had positive SV40, it is still pending in one case(5).The occurrence of urothelial cancer in transplant ureter along with bladder cancer in this patient, with tumor genotype revealing recipient tissue rather than donor, in the presence of BKV, points towards the possibility of + SV40 in the tissue.Other interesting findings are SV40+ in a lymph node metastasis(4) and the SV40+ tumor in allograft nephrectomy tissue 2 years after the allograft failed(3)
While the potential oncogenic role of BKV is unclear, the increasing no. of reported renourinary tract tumors in patients with BKV, and the long latent period after transplant, warrant increased vigilance for early detection of cancers in patients with persistent BKV particularly in highly immunocompromised patients (dual organ transplants , ATG induction).
CITATION INFORMATION: Prashar R, Shah A, Stewart D, Williamson S, Patel A. BK Polyoma Virus and Malignancy: Cause or Co-Incidence? Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Prashar R, Shah A, Stewart D, Williamson S, Patel A. BK Polyoma Virus and Malignancy: Cause or Co-Incidence? [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/bk-polyoma-virus-and-malignancy-cause-or-co-incidence/. Accessed October 22, 2020.
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