ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Non-invasive diagnosis"

  • 2021 American Transplant Congress

    High Levels of Donor-Derived Cell-Free DNA Predict EGFR Decline After Kidney Transplantation

    T. Alhamad1, V. Bowers2, E. Stites3, S. Anand4, J. S. Bromberg5, H. Murad1, G. Gupta6, I. Moinuddin6, L. Bu7, S. Ghosh8, J. Zeng8, A. Pai9

    1Washington University in St. Louis, St. Louis, MO, 2Tampa General Hospital, Tampa, FL, 3University of Colorado, Aurora, CO, 4Intermountain Medical Center, Murray, UT, 5University of Maryland School of Medicine, Baltimore, MD, 6Virginia Commonwealth University, Richmond, VA, 7University of Minnesota, Minneapolis, MN, 8CareDx, Brisbane, CA, 9University of Texas McGovern Medical School, Houston, TX

    *Purpose: Persistent, low-grade inflammation is associated with decline in eGFR. Cross-sectional studies have demonstrated a consistent association between circulating inflammatory markers and kidney function. Our…
  • 2021 American Transplant Congress

    Benign Pneumatosis Intestinalis with Pneumoperitoneum in the Immunocompromised Patient: Three Cases

    A. Mohamed, K. Delvecchio, T. Kitajima, M. Rizzari, K. Collins, A. Yoshida, S. Nagai, J. Denny, M. Abouljoud

    Department of Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI

    *Purpose: Isolated pneumatosis intestinalis after solid organ transplantation, as well as its surgical management in appropriate clinical context, is a well described entity. The management…
  • 2021 American Transplant Congress

    Assessment of Donor-Derived Cell-Free DNA Performance Characteristics Across the Spectrum of TCMR and ABMR After Kidney Transplant

    L. Bu1, S. Anand2, A. Pai3, J. S. Bromberg4, T. Alhamad5, V. Bowers6, I. Moinuddin7, S. Ghosh8, W. Tian8, E. Stites9, G. Gupta7

    1University of Minnesota, Minneapolis, MN, 2Intermountain Medical Center, Murray, UT, 3University of Texas McGovern Medical School, Houston, TX, 4University of Maryland School of Medicine, Baltimore, MD, 5Washington University in St. Louis, St. Louis, MO, 6Tampa General Hospital, Tampa, FL, 7Virginia Commonwealth University, Richmond, VA, 8CareDx, Brisbane, CA, 9University of Colorado, Aurora, CO

    *Purpose: Different donor-derived cell-free DNA (dd-cfDNA) thresholds have been reported in association with varying TCMR, ABMR and “Borderline” diagnoses. Interpretation of dd-cfDNA levels spanning active…
  • 2021 American Transplant Congress

    Kidney Transplant Rejection Can Be Diagnosed or Even Predicted by Tracking Donor Reactive T Cell Clones in Post-transplant Samples

    Y. Sambandam1, M. Kandpal1, J. He1, X. Huang1, T. S. Taylor1, A. A. Shetty2, J. M. Mathew1, J. R. Leventhal1

    1Surgery-Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Medicine, Nephrology Division, Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: To test if kidney transplant (KTx) rejection can be diagnosed by monitoring for donor reactive T-cell (DRTC) clones in post-transplant (post-tx) biopsy and non-invasively…
  • 2021 American Transplant Congress

    Donor-Derived Cell-Free DNA Levels Risk-Stratify Polyoma BK Viremia and Associated Clinical Events After Kidney Transplantation – Preliminary Results from ADMIRAL Study

    A. Pai1, L. Bu2, J. S. Bromberg3, G. Gupta4, I. Moinuddin4, T. Alhamad5, V. Bowers6, S. Ghosh7, W. Tian7, E. Stites8, S. Anand9

    1University of Texas McGovern Medical School, Houston, TX, 2University of Minnesota, Minneapolis, MN, 3University of Maryland School of Medicine, Baltimore, MD, 4Virginia Commonwealth University, Richmond, VA, 5Washington University in St. Louis, St. Louis, MO, 6Tampa General Hospital, Tampa, FL, 7CareDx, Brisbane, CA, 8University of Colorado, Aurora, CO, 9Intermountain Medical Center, Murray, UT

    *Purpose: The threshold of 10,000 copies for blood Quant BK PCR has been used as a surrogate for BK nephropathy (BKN) in kidney transplant recipients…
  • 2021 American Transplant Congress

    High Donor-Derived Cell-Free DNA Levels Predict Development of De Novo HLA Donor-Specific Antibodies After Kidney Transplantation – Data from the ADMIRAL Study

    G. Gupta1, T. Alhamad2, V. Bowers3, I. Moinuddin1, S. Ghosh4, J. Zeng4, E. Stites5, A. Pai6, J. S. Bromberg7, S. Anand8

    1Virginia Commonwealth University, Richmond, VA, 2Washington University in St. Louis, St. Louis, MO, 3Tampa General Hospital, Tampa, FL, 4CareDx, Brisbane, CA, 5University of Colorado, Aurora, CO, 6University of Texas McGovern Medical School, Houston, TX, 7University of Maryland School of Medicine, Baltimore, MD, 8Intermountain Medical Center, Murray, UT

    *Purpose: Donor-derived cell-free DNA (dd-cfDNA) as a marker of injury can serve to quantify subclinical inflammation and molecular injury. As the release of graft genomic…
  • 2021 American Transplant Congress

    Urinary Exosomal Cystatin C and Lipopolysaccharide Binding Protein as Biomarkers for Monitoring Antibody-mediated Rejection After Kidney Transplantation

    M. Kim, S. Lim, S. Shin

    Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of

    *Purpose: This study aims to discover and validate urinary exosomal biomarkers for antibody-mediated rejection (ABMR) after kidney transplantation.*Methods: A total of 60 urine samples from…
  • 2021 American Transplant Congress

    Donor-derived Cell-free DNA in Upper Extremity Vascular Composite Allograft Recipients

    R. Kalsi1, M. Abuzeineh2, J. Littleton1, J. T. Shores1, D. S. Cooney1, C. Cooney1, R. J. Redett1, G. Brandacher1, D. C. Brennan2

    1Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD, 2Nephrology, Johns Hopkins University, Baltimore, MD

    *Purpose: Diagnosing rejection in VCA recipients relies on clinical exam and biopsy which are both easily confounded by common causes of skin irritation. dd-cfDNA in…
  • 2021 American Transplant Congress

    Donor-Derived Cell-Free DNA Performance Characteristics are Similar for Repeat and Primary Kidney Transplant Recipients

    V. R. Peddi1, S. Akkina2, S. C. Jordan3, W. Tian4, Y. Qazi5

    1California Pacific Medical Center, San Francisco, CA, 2Loyola University Medical Center, Maywood, IL, 3Cedars-Sinai Medical Center, Los Angeles, CA, 4CareDx, Brisbane, CA, 5University of Southern California, Los Angeles, CA

    *Purpose: Repeat kidney transplants (RKT) represent 12.4% of kidney transplants (KT) (10.9% of all living donor and 13.6% of all deceased donor). Most RKT are…
  • 2021 American Transplant Congress

    Nonadherence Post-kidney Transplant is Associated with Increased Immune Activation Detected by Peripheral Blood Gene Expression Assay

    N. Singh1, A. Palermini1, M. S. Naseer1, T. Le1, S. Tandukar1, D. Aultman2, H. Shokouh-Amiri2, G. Zibari2

    1Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, 2Advanced Surgery, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA

    *Purpose: Nonadherence to immunosuppression medications is common post-transplantation. We hypothesize that nonadherence results in a heightened alloimmune response in kidney transplant recipients (KTRs) which in…
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