2018 American Transplant Congress
Death-Censored Graft Failure (DCGF) Post Kidney Transplant (KTx) is Usually the Result of Rapid Loss of Function after Periods of Stability
Late graft dysfunction leading to clinically indicated transplant biopsy (KTxBx) is a better predictor of subsequent DCGF than baseline data and early post-transplant events (Gaston…2018 American Transplant Congress
T Cell-Mediated Rejection Poses Greater Risk to Graft Survival Than Antibody-Mediated Rejection in Heart Transplants
University of Alberta, Edmonton, Canada.
Purpose: In kidney transplants, failure post-biopsy is associated with acute injury transcript expression reflecting the histologically silent tissue response-to-wounding (JCI 120:1862) and antibody-mediated rejection (ABMR),…2018 American Transplant Congress
Livers from Diabetic Donors Can Safely Be Used in Donation after Circulatory Death Liver Transplantation
Liver grafts from donors with a history of diabetes mellitus (DM) have been associated with reduced graft survival after liver transplantation. Transplantation centers are often…2018 American Transplant Congress
Direct-Acting Antiviral Therapy Immune-Mediated Graft Dysfunction in Liver Transplant Recipients with Hepatitis C
Background and Aims:Interferon (IFN) treatment of hepatitis C virus (HCV) infection after liver transplantation (LT) can result in severe immune-mediated graft dysfunction (IGD). The occurrence…2018 American Transplant Congress
Serum Cytokines as Markers of Influenza Infection Outcomes after Transplantation
Background:Influenza infection in transplant patients can be severe but factors predictive of outcome in this setting are unclear. The aim of the study was to…2018 American Transplant Congress
Factor Analysis (FA) Identifies 5 Major Axes of Kidney Transplant Biopsy (KTxBx) Pathology
Definitions for acute rejection (ACR) and antibody mediated rejection (AMR) in KTxBx exist, but no data driven methods exist for quantitative analysis of all Banff,…2018 American Transplant Congress
Effect of Acute Vascular Inflammation (v) on Death Censored Graft Failure (DCGF) Following Kidney Transplant (KTx)
The impact of acute vascular inflammation in acute cellular or humoral rejection following KTx, and the effect of isolated vascular inflammatory lesions on late DCGF,…2018 American Transplant Congress
Factor Analysis (FA) of Renal Transplant Biopsy (KTxBx) Data Enables Objective Assessment of Risk for Subsequent Death Censored Graft Failure (DCGF)
We examined the impact of five axes of injury identified by FA in the KTxBx on the hazard for subsequent DCGF in two DeKAF cohorts.Methods:…2018 American Transplant Congress
Population-Based Modeling of Prototypes and Determinants of Allograft Function Trajectories after Kidney Transplantation: Implications for Patient Monitoring and Risk Stratification
Paris Transplant Group, Paris, France.
Background:Although the current gold standard of monitoring kidney allograft patients relies primarily on GFR assessment, little is known about long-term eGFR trajectories prototypes and their…2017 American Transplant Congress
Variability in Tacrolimus Concentrations Across Pediatric Solid Organ Transplants.
PURPOSE: We characterized the evolution of out-of-range tacrolimus (TAC) concentrations and associated factors during 1 year following a pediatric solid organ transplant (SOT).METHODS: Heart, kidney…
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