ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mixed chimerism"

  • 2020 American Transplant Congress

    Inducing Donor MHC Chimerism with Bone Marrow Derived Exosomes in Non-Human Primates

    P. M. Patel1, B. A. Gonzalez Nolasco1, J. A. Morrissette1, A. Prunevieille1, K. J. Ahrens1, J. M. O1, D. C. Becerra1, G. Benichou1, J. C. Madsen2

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA

    *Purpose: Cardiac allograft tolerance in non-human primates (NHPs) has been achieved by our group via hematopoietic mixed chimerism consisting of an allogeneic bone marrow (BM)…
  • 2019 American Transplant Congress

    MHC Cross-Dressing in Mixed Hematopoietic Chimerism

    B. Gonzalez Nolasco1, M. Wang1, W. Orent1, A. Prunevieille1, K. Pruner1, J. O1, J. Paster1, J. C. Madsen2, G. Benichou1

    1Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Achieving specific long-term allograft survival without ongoing immunosuppression is one of the main objectives in transplantation. Mixed hematopoietic chimerism is a strategy that has…
  • 2019 American Transplant Congress

    Bcl-2/Bcl-xL Inhibition by Navitoclax vs. Bcl-2 Alone Inhibition by Venetoclax for Induction of Mixed Chimerism in Non-Human Primates

    H. Sasaki1, D. Ma1, T. Oura1, A. Dehnadi1, I. Rosales2, B. Cosimi1, P. Cippa3, T. Fehr3, T. Kawai1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Pathology, Massachusetts General Hospital, Boston, MA, 3Medicine, University of Zurich, Zurich, Switzerland

    *Purpose: We recently demonstrated that a specific Bcl-2 inhibitor, Venetoclax, can promote mixed chimerism and renal allograft tolerance in non-human primates (NHPs) with reduced myelosuppressive…
  • 2019 American Transplant Congress

    Donor-Specific Tregs Prolong Peripheral Chimerism in Baboons Receiving GalTKO hCD47-tg Porcine Peripheral Blood Stem Cells

    N. P. Llore1, J. Stern1, G. Pierre1, E. Lopes1, D. Ekanayake-Alper1, P. Alonso-Guallart1, K. Bruestle1, H. Sakai1, D. Ayares2, M. Lorber2, R. Hawley1, D. H. Sachs1, M. Sykes1, A. D. Griesemer1

    1Columbia Center for Translational Immunology, New York, NY, 2United Therapeutics, Silver Springs, MD

    *Purpose: We have previously evaluated the ability of transplantation of polyclonal expanded recipient T regulatory cells to prolong xenogeneic chimerism and skin grafts after transplantation…
  • 2019 American Transplant Congress

    Bcl-2 Inhibition with Venetoclax Promotes Induction of Mixed Chimerism and Renal Allograft Tolerance without Severe Myelosuppression in Non-Human Primate

    H. Sasaki1, D. Ma1, T. Oura1, A. Dehnadi1, I. Rosales2, B. Cosimi1, P. Cippa3, T. Fehr3, T. Kawai1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Pathology, Massachusetts General Hospital, Boston, MA, 3Medicine, University of Zurich, Zurich, Switzerland

    *Purpose: Specific Bcl-2 inhibition has been shown to promote mixed chimerism and skin allograft tolerance without myelosuppressive conditioning in murine models. To extend this approach…
  • 2019 American Transplant Congress

    Tolerance Induction with Hematopoietic Stem Cells in Kidney Transplantations

    K. Lee, J. Park, Y. Chung, S. Kim

    Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: Tolerance induction is considered to be the final goal in the field of organ transplantation. We have performed combined bone marrow and kidney transplantation…
  • 2019 American Transplant Congress

    Prolongation of Allograft Survival via Donor MHC Chimerism Induced by Exosomes

    B. Gonzalez Nolasco1, M. Wang1, W. Orent1, A. Prunevieille1, J. O1, K. Ahrens1, J. C. Madsen2, G. Benichou1

    1Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Achieving robust and durable host immune tolerance of allogeneic transplants is the ultimate goal in clinical transplantation. Mixed chimerism induced via donor bone marrow…
  • 2019 American Transplant Congress

    Expansion of Regulatory T and B Cells in Swine Rendered Tolerant of Allogeneic Vascularized Composite Allografts via Mixed Chimerism

    G. Saviane1, A. Lellouch1, A. Andrews1, L. Lantieri2, M. Randolph1, G. Benichou1, C. Cetrulo Jr1

    1Center for Transplantation Sciences, Division of Plastic Surgery, Boston, MA, USA, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA, 2European Georges Pompidou Hospital, University of Paris, Department of Plastic Surgery, Paris, France

    *Purpose: Prevention of acute rejection of vascularized composite allografts (VCAs) requires ongoing systemic immunosuppression, which subject patients to infectious, metabolic, reno-vascular and neoplastic complications. It…
  • 2019 American Transplant Congress

    Significantly High FOXP3 mRNA in the Renal Allograft as a Mechanism of Tolerance Induced by Transient Mixed Chimerism in Non-Human Primates

    M. Matsunami1, I. Rosales1, T. Oura1, B. Adam2, M. Mengel2, R. Smith1, A. Cosimi1, R. Colvin1, T. Kawai1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada

    *Purpose: Treg-rich organized lymphoid structures (TOLS) has been identified in recipients with renal allograft tolerance induced by transient mixed chimerism in non-human primates (NHPs) and…
  • 2019 American Transplant Congress

    After 10 Years: The Results of HLA Mismatched Combined Kidney and Bone Marrow Transplantation for Renal Allograft Tolerance

    T. Kawai1, D. H. Sachs1, T. Spitzer1, N. Tolkoff-Rubin1, R. B. Colvin1, N. Elias1, M. Sykes2, A. Cosimi1

    1Massachusetts General Hospital, Boston, MA, 2Columbia University, NYC, NY

    *Purpose: Based on decades-long basic studies in animal models, we have applied combined kidney and donor bone marrow transplantation (CKBMT) for induction of allograft tolerance…
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