ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Articles tagged "Mixed chimerism"

  • 2020 American Transplant Congress

    Interim Experience in a Phase 3 Prospective, Randomized, Multi-Center, Open-Label, Controlled Trial of Cellular Immunotherapy with MDR-101 for Induction of Immune Tolerance in Recipients of HLA-Matched, Living Donor Kidney Transplants

    D. Kaufman1, J. Piper2, M. Stegall3, S. Akkina4, E. Marin5, A. Gaber6, Y. Qasi7, T. Srinivas8, D. Alonso9, A. Patel10, M. Laftavi11, A. Shah12, S. Collette13, E. Stites14, K. Chavin8, S. Crowley15

    1UW, Madison, WI, 2INOVA, Fairfax, VA, 3Mayo, Rochester, MN, 4LUMC, Chicago, IL, 5Yale, New Haven, CT, 6Houston Methodist, Houston, TX, 7USC, Los Angeles, CA, 8UH Cleveland, Cleveland, OH, 9Intermountain, Murray, UT, 10SBMC, Livingston, NJ, 11UH Upstate, Syracuse, NY, 12TJU, Philadelphia, PA, 13CIUSSS, Montreal, QC, Canada, 14UCH, Denver, CO, 15Medeor, San Francisco, CA

    *Purpose: The goals of tolerance in patients with kidney transplants (KTxp) are to eliminate the lifelong need for immunosuppressive drugs (IS) and to prevent graft…
  • 2020 American Transplant Congress

    Orthogonal IL-2 Cytokine-Receptor Pair Capable of Selective Expansion of Regulatory T Cells Facilitates Alloengraftment

    T. Hirai1, F. Simonetta2, L. L. Su3, L. Picton3, J. Baker2, J. Lin4, P. Li4, W. J. Leonard4, K. C. Garcia3, R. S. Negrin2

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, 2Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA, 3Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA, 4Laboratory of Molecular Immunology, National Institutes of Health, Bethesda, MD

    *Purpose: Adoptive transfer of regulatory T cells (Tregs) has been shown to improve alloengraftment in animal models. However, ex vivo Treg expansion for the purpose…
  • 2020 American Transplant Congress

    Induction of Delayed Immune Tolerance after Reconstructive Transplantation by Combining Donor Bone Marrow Transplantation and High-Dose Cyclophosphamide Treatment

    Y. Guo1, F. Messner1, B. Oh1, G. Furtmüller1, W. Lee1, D. Cooney1, L. Luznik2, G. Brandacher1

    1Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 2Hematology, Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Immunosuppression avoidance by induction of immune tolerance represents a primary goal in the field of transplantation. Yet, success of this concept relies on extensive…
  • 2020 American Transplant Congress

    Inducing Donor MHC Chimerism with Bone Marrow Derived Exosomes in Non-Human Primates

    P. M. Patel1, B. A. Gonzalez Nolasco1, J. A. Morrissette1, A. Prunevieille1, K. J. Ahrens1, J. M. O1, D. C. Becerra1, G. Benichou1, J. C. Madsen2

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA

    *Purpose: Cardiac allograft tolerance in non-human primates (NHPs) has been achieved by our group via hematopoietic mixed chimerism consisting of an allogeneic bone marrow (BM)…
  • 2019 American Transplant Congress

    MHC Cross-Dressing in Mixed Hematopoietic Chimerism

    B. Gonzalez Nolasco1, M. Wang1, W. Orent1, A. Prunevieille1, K. Pruner1, J. O1, J. Paster1, J. C. Madsen2, G. Benichou1

    1Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Achieving specific long-term allograft survival without ongoing immunosuppression is one of the main objectives in transplantation. Mixed hematopoietic chimerism is a strategy that has…
  • 2019 American Transplant Congress

    Bcl-2/Bcl-xL Inhibition by Navitoclax vs. Bcl-2 Alone Inhibition by Venetoclax for Induction of Mixed Chimerism in Non-Human Primates

    H. Sasaki1, D. Ma1, T. Oura1, A. Dehnadi1, I. Rosales2, B. Cosimi1, P. Cippa3, T. Fehr3, T. Kawai1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Pathology, Massachusetts General Hospital, Boston, MA, 3Medicine, University of Zurich, Zurich, Switzerland

    *Purpose: We recently demonstrated that a specific Bcl-2 inhibitor, Venetoclax, can promote mixed chimerism and renal allograft tolerance in non-human primates (NHPs) with reduced myelosuppressive…
  • 2019 American Transplant Congress

    Donor-Specific Tregs Prolong Peripheral Chimerism in Baboons Receiving GalTKO hCD47-tg Porcine Peripheral Blood Stem Cells

    N. P. Llore1, J. Stern1, G. Pierre1, E. Lopes1, D. Ekanayake-Alper1, P. Alonso-Guallart1, K. Bruestle1, H. Sakai1, D. Ayares2, M. Lorber2, R. Hawley1, D. H. Sachs1, M. Sykes1, A. D. Griesemer1

    1Columbia Center for Translational Immunology, New York, NY, 2United Therapeutics, Silver Springs, MD

    *Purpose: We have previously evaluated the ability of transplantation of polyclonal expanded recipient T regulatory cells to prolong xenogeneic chimerism and skin grafts after transplantation…
  • 2019 American Transplant Congress

    Bcl-2 Inhibition with Venetoclax Promotes Induction of Mixed Chimerism and Renal Allograft Tolerance without Severe Myelosuppression in Non-Human Primate

    H. Sasaki1, D. Ma1, T. Oura1, A. Dehnadi1, I. Rosales2, B. Cosimi1, P. Cippa3, T. Fehr3, T. Kawai1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Pathology, Massachusetts General Hospital, Boston, MA, 3Medicine, University of Zurich, Zurich, Switzerland

    *Purpose: Specific Bcl-2 inhibition has been shown to promote mixed chimerism and skin allograft tolerance without myelosuppressive conditioning in murine models. To extend this approach…
  • 2019 American Transplant Congress

    Tolerance Induction with Hematopoietic Stem Cells in Kidney Transplantations

    K. Lee, J. Park, Y. Chung, S. Kim

    Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: Tolerance induction is considered to be the final goal in the field of organ transplantation. We have performed combined bone marrow and kidney transplantation…
  • 2019 American Transplant Congress

    Prolongation of Allograft Survival via Donor MHC Chimerism Induced by Exosomes

    B. Gonzalez Nolasco1, M. Wang1, W. Orent1, A. Prunevieille1, J. O1, K. Ahrens1, J. C. Madsen2, G. Benichou1

    1Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Achieving robust and durable host immune tolerance of allogeneic transplants is the ultimate goal in clinical transplantation. Mixed chimerism induced via donor bone marrow…
  • 1
  • 2
  • 3
  • …
  • 6
  • Next Page »

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
      • Direct Oral Anticoagulation Use in Kidney Transplant Recipients

      Visit Our Partner Sites

      American Transplant Congress (ATC)

      Visit the official site for the American Transplant Congress »

      American Journal of Transplantation

      The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

      American Society of Transplantation (AST)

      An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

      American Society of Transplant Surgeons (ASTS)

      The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

      Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

      Privacy Policy | Terms of Use

      This site uses cookies: Find out more.