ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mixed chimerism"

  • 2020 American Transplant Congress

    Interim Experience in a Phase 3 Prospective, Randomized, Multi-Center, Open-Label, Controlled Trial of Cellular Immunotherapy with MDR-101 for Induction of Immune Tolerance in Recipients of HLA-Matched, Living Donor Kidney Transplants

    D. Kaufman1, J. Piper2, M. Stegall3, S. Akkina4, E. Marin5, A. Gaber6, Y. Qasi7, T. Srinivas8, D. Alonso9, A. Patel10, M. Laftavi11, A. Shah12, S. Collette13, E. Stites14, K. Chavin8, S. Crowley15

    1UW, Madison, WI, 2INOVA, Fairfax, VA, 3Mayo, Rochester, MN, 4LUMC, Chicago, IL, 5Yale, New Haven, CT, 6Houston Methodist, Houston, TX, 7USC, Los Angeles, CA, 8UH Cleveland, Cleveland, OH, 9Intermountain, Murray, UT, 10SBMC, Livingston, NJ, 11UH Upstate, Syracuse, NY, 12TJU, Philadelphia, PA, 13CIUSSS, Montreal, QC, Canada, 14UCH, Denver, CO, 15Medeor, San Francisco, CA

    *Purpose: The goals of tolerance in patients with kidney transplants (KTxp) are to eliminate the lifelong need for immunosuppressive drugs (IS) and to prevent graft…
  • 2019 American Transplant Congress

    Bcl-2 Inhibition with Venetoclax Promotes Induction of Mixed Chimerism and Renal Allograft Tolerance without Severe Myelosuppression in Non-Human Primate

    H. Sasaki1, D. Ma1, T. Oura1, A. Dehnadi1, I. Rosales2, B. Cosimi1, P. Cippa3, T. Fehr3, T. Kawai1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Pathology, Massachusetts General Hospital, Boston, MA, 3Medicine, University of Zurich, Zurich, Switzerland

    *Purpose: Specific Bcl-2 inhibition has been shown to promote mixed chimerism and skin allograft tolerance without myelosuppressive conditioning in murine models. To extend this approach…
  • 2019 American Transplant Congress

    Tolerance Induction with Hematopoietic Stem Cells in Kidney Transplantations

    K. Lee, J. Park, Y. Chung, S. Kim

    Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: Tolerance induction is considered to be the final goal in the field of organ transplantation. We have performed combined bone marrow and kidney transplantation…
  • 2019 American Transplant Congress

    Prolongation of Allograft Survival via Donor MHC Chimerism Induced by Exosomes

    B. Gonzalez Nolasco1, M. Wang1, W. Orent1, A. Prunevieille1, J. O1, K. Ahrens1, J. C. Madsen2, G. Benichou1

    1Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Achieving robust and durable host immune tolerance of allogeneic transplants is the ultimate goal in clinical transplantation. Mixed chimerism induced via donor bone marrow…
  • 2019 American Transplant Congress

    Expansion of Regulatory T and B Cells in Swine Rendered Tolerant of Allogeneic Vascularized Composite Allografts via Mixed Chimerism

    G. Saviane1, A. Lellouch1, A. Andrews1, L. Lantieri2, M. Randolph1, G. Benichou1, C. Cetrulo Jr1

    1Center for Transplantation Sciences, Division of Plastic Surgery, Boston, MA, USA, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA, 2European Georges Pompidou Hospital, University of Paris, Department of Plastic Surgery, Paris, France

    *Purpose: Prevention of acute rejection of vascularized composite allografts (VCAs) requires ongoing systemic immunosuppression, which subject patients to infectious, metabolic, reno-vascular and neoplastic complications. It…
  • 2019 American Transplant Congress

    Significantly High FOXP3 mRNA in the Renal Allograft as a Mechanism of Tolerance Induced by Transient Mixed Chimerism in Non-Human Primates

    M. Matsunami1, I. Rosales1, T. Oura1, B. Adam2, M. Mengel2, R. Smith1, A. Cosimi1, R. Colvin1, T. Kawai1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada

    *Purpose: Treg-rich organized lymphoid structures (TOLS) has been identified in recipients with renal allograft tolerance induced by transient mixed chimerism in non-human primates (NHPs) and…
  • 2019 American Transplant Congress

    After 10 Years: The Results of HLA Mismatched Combined Kidney and Bone Marrow Transplantation for Renal Allograft Tolerance

    T. Kawai1, D. H. Sachs1, T. Spitzer1, N. Tolkoff-Rubin1, R. B. Colvin1, N. Elias1, M. Sykes2, A. Cosimi1

    1Massachusetts General Hospital, Boston, MA, 2Columbia University, NYC, NY

    *Purpose: Based on decades-long basic studies in animal models, we have applied combined kidney and donor bone marrow transplantation (CKBMT) for induction of allograft tolerance…
  • 2019 American Transplant Congress

    Desensitization Using Costimulatory Blockade and Bortezomib Does Not Prevent DSA Formation and Rejection in Reconstructive Transplantation

    F. Messner1, Y. Guo1, R. Chen2, Y. Kuo2, G. Brandacher1, B. Oh1

    1Department of Plastic and Reconstructive Surgery, Johns Hopkins UJohns Hopkins University School of Medicine, Baltimore, MD, 2Division of Plastic Surgery, Kaohsiung Medical Univerity Hospital, Kaohsiung, Taiwan

    *Purpose: Sensitiziation in form of donor-specific antibodies (DSA) and subsequent antibody-mediated rejection (AMR) constitute some of the greatest risk factors for allograft rejection and long-term…
  • 2019 American Transplant Congress

    A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Lymphocyte Biology and Transplant Immunity

    L. Qiu1, J. Wang2, R. Fernandez3, X. Yeap1, S. Han1, F. Zheng1, C. Lin2, Z. J. Zhang1

    1Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, 2Northwestern University, Chicago, IL, 3Department of Surgery, Northwestern University, Chicago, IL

    *Purpose: Spleen-derived lymphocytes and myeloid cell populations are critical to the development of organ transplant ischemia-reperfusion injury (IRI) and allograft rejection. In this study, we…
  • 2019 American Transplant Congress

    Full and Sustained Donor Hematopoietic Chimerism after an Isolated Kidney Transplantation

    J. Zuber1, O. Boyer1, B. Neven1, E. Six2, R. Berthaud1, M. Ould Rabah1, S. Sobrino2, C. Lagresle2, I. André-Schmutz2, M. Cavazzana1, S. Blanche1, R. Salomon1

    1Paris Descartes University, Paris, France, 2Inserm UMRS 1163, Paris, France

    *Purpose: Full donor chimerism was reported three times in the absence of myelosuppressive regimen, only after liver or multivisceral transplantation, but never after kidney transplantation.…
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