2020 American Transplant Congress
Inducing Donor MHC Chimerism with Bone Marrow Derived Exosomes in Non-Human Primates
*Purpose: Cardiac allograft tolerance in non-human primates (NHPs) has been achieved by our group via hematopoietic mixed chimerism consisting of an allogeneic bone marrow (BM)…2019 American Transplant Congress
After 10 Years: The Results of HLA Mismatched Combined Kidney and Bone Marrow Transplantation for Renal Allograft Tolerance
1Massachusetts General Hospital, Boston, MA, 2Columbia University, NYC, NY
*Purpose: Based on decades-long basic studies in animal models, we have applied combined kidney and donor bone marrow transplantation (CKBMT) for induction of allograft tolerance…2019 American Transplant Congress
Desensitization Using Costimulatory Blockade and Bortezomib Does Not Prevent DSA Formation and Rejection in Reconstructive Transplantation
*Purpose: Sensitiziation in form of donor-specific antibodies (DSA) and subsequent antibody-mediated rejection (AMR) constitute some of the greatest risk factors for allograft rejection and long-term…2019 American Transplant Congress
A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Lymphocyte Biology and Transplant Immunity
*Purpose: Spleen-derived lymphocytes and myeloid cell populations are critical to the development of organ transplant ischemia-reperfusion injury (IRI) and allograft rejection. In this study, we…2019 American Transplant Congress
Full and Sustained Donor Hematopoietic Chimerism after an Isolated Kidney Transplantation
1Paris Descartes University, Paris, France, 2Inserm UMRS 1163, Paris, France
*Purpose: Full donor chimerism was reported three times in the absence of myelosuppressive regimen, only after liver or multivisceral transplantation, but never after kidney transplantation.…2019 American Transplant Congress
MHC Cross-Dressing in Mixed Hematopoietic Chimerism
*Purpose: Achieving specific long-term allograft survival without ongoing immunosuppression is one of the main objectives in transplantation. Mixed hematopoietic chimerism is a strategy that has…2019 American Transplant Congress
Bcl-2/Bcl-xL Inhibition by Navitoclax vs. Bcl-2 Alone Inhibition by Venetoclax for Induction of Mixed Chimerism in Non-Human Primates
*Purpose: We recently demonstrated that a specific Bcl-2 inhibitor, Venetoclax, can promote mixed chimerism and renal allograft tolerance in non-human primates (NHPs) with reduced myelosuppressive…2019 American Transplant Congress
Donor-Specific Tregs Prolong Peripheral Chimerism in Baboons Receiving GalTKO hCD47-tg Porcine Peripheral Blood Stem Cells
*Purpose: We have previously evaluated the ability of transplantation of polyclonal expanded recipient T regulatory cells to prolong xenogeneic chimerism and skin grafts after transplantation…2019 American Transplant Congress
Bcl-2 Inhibition with Venetoclax Promotes Induction of Mixed Chimerism and Renal Allograft Tolerance without Severe Myelosuppression in Non-Human Primate
*Purpose: Specific Bcl-2 inhibition has been shown to promote mixed chimerism and skin allograft tolerance without myelosuppressive conditioning in murine models. To extend this approach…2019 American Transplant Congress
Tolerance Induction with Hematopoietic Stem Cells in Kidney Transplantations
Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Tolerance induction is considered to be the final goal in the field of organ transplantation. We have performed combined bone marrow and kidney transplantation…
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