ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mixed chimerism"

  • 2020 American Transplant Congress

    Inducing Donor MHC Chimerism with Bone Marrow Derived Exosomes in Non-Human Primates

    P. M. Patel1, B. A. Gonzalez Nolasco1, J. A. Morrissette1, A. Prunevieille1, K. J. Ahrens1, J. M. O1, D. C. Becerra1, G. Benichou1, J. C. Madsen2

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA

    *Purpose: Cardiac allograft tolerance in non-human primates (NHPs) has been achieved by our group via hematopoietic mixed chimerism consisting of an allogeneic bone marrow (BM)…
  • 2019 American Transplant Congress

    Desensitization Using Costimulatory Blockade and Bortezomib Does Not Prevent DSA Formation and Rejection in Reconstructive Transplantation

    F. Messner1, Y. Guo1, R. Chen2, Y. Kuo2, G. Brandacher1, B. Oh1

    1Department of Plastic and Reconstructive Surgery, Johns Hopkins UJohns Hopkins University School of Medicine, Baltimore, MD, 2Division of Plastic Surgery, Kaohsiung Medical Univerity Hospital, Kaohsiung, Taiwan

    *Purpose: Sensitiziation in form of donor-specific antibodies (DSA) and subsequent antibody-mediated rejection (AMR) constitute some of the greatest risk factors for allograft rejection and long-term…
  • 2019 American Transplant Congress

    A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Lymphocyte Biology and Transplant Immunity

    L. Qiu1, J. Wang2, R. Fernandez3, X. Yeap1, S. Han1, F. Zheng1, C. Lin2, Z. J. Zhang1

    1Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, 2Northwestern University, Chicago, IL, 3Department of Surgery, Northwestern University, Chicago, IL

    *Purpose: Spleen-derived lymphocytes and myeloid cell populations are critical to the development of organ transplant ischemia-reperfusion injury (IRI) and allograft rejection. In this study, we…
  • 2019 American Transplant Congress

    Full and Sustained Donor Hematopoietic Chimerism after an Isolated Kidney Transplantation

    J. Zuber1, O. Boyer1, B. Neven1, E. Six2, R. Berthaud1, M. Ould Rabah1, S. Sobrino2, C. Lagresle2, I. André-Schmutz2, M. Cavazzana1, S. Blanche1, R. Salomon1

    1Paris Descartes University, Paris, France, 2Inserm UMRS 1163, Paris, France

    *Purpose: Full donor chimerism was reported three times in the absence of myelosuppressive regimen, only after liver or multivisceral transplantation, but never after kidney transplantation.…
  • 2019 American Transplant Congress

    MHC Cross-Dressing in Mixed Hematopoietic Chimerism

    B. Gonzalez Nolasco1, M. Wang1, W. Orent1, A. Prunevieille1, K. Pruner1, J. O1, J. Paster1, J. C. Madsen2, G. Benichou1

    1Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Achieving specific long-term allograft survival without ongoing immunosuppression is one of the main objectives in transplantation. Mixed hematopoietic chimerism is a strategy that has…
  • 2019 American Transplant Congress

    Bcl-2/Bcl-xL Inhibition by Navitoclax vs. Bcl-2 Alone Inhibition by Venetoclax for Induction of Mixed Chimerism in Non-Human Primates

    H. Sasaki1, D. Ma1, T. Oura1, A. Dehnadi1, I. Rosales2, B. Cosimi1, P. Cippa3, T. Fehr3, T. Kawai1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Pathology, Massachusetts General Hospital, Boston, MA, 3Medicine, University of Zurich, Zurich, Switzerland

    *Purpose: We recently demonstrated that a specific Bcl-2 inhibitor, Venetoclax, can promote mixed chimerism and renal allograft tolerance in non-human primates (NHPs) with reduced myelosuppressive…
  • 2019 American Transplant Congress

    Donor-Specific Tregs Prolong Peripheral Chimerism in Baboons Receiving GalTKO hCD47-tg Porcine Peripheral Blood Stem Cells

    N. P. Llore1, J. Stern1, G. Pierre1, E. Lopes1, D. Ekanayake-Alper1, P. Alonso-Guallart1, K. Bruestle1, H. Sakai1, D. Ayares2, M. Lorber2, R. Hawley1, D. H. Sachs1, M. Sykes1, A. D. Griesemer1

    1Columbia Center for Translational Immunology, New York, NY, 2United Therapeutics, Silver Springs, MD

    *Purpose: We have previously evaluated the ability of transplantation of polyclonal expanded recipient T regulatory cells to prolong xenogeneic chimerism and skin grafts after transplantation…
  • 2019 American Transplant Congress

    Bcl-2 Inhibition with Venetoclax Promotes Induction of Mixed Chimerism and Renal Allograft Tolerance without Severe Myelosuppression in Non-Human Primate

    H. Sasaki1, D. Ma1, T. Oura1, A. Dehnadi1, I. Rosales2, B. Cosimi1, P. Cippa3, T. Fehr3, T. Kawai1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Pathology, Massachusetts General Hospital, Boston, MA, 3Medicine, University of Zurich, Zurich, Switzerland

    *Purpose: Specific Bcl-2 inhibition has been shown to promote mixed chimerism and skin allograft tolerance without myelosuppressive conditioning in murine models. To extend this approach…
  • 2019 American Transplant Congress

    Tolerance Induction with Hematopoietic Stem Cells in Kidney Transplantations

    K. Lee, J. Park, Y. Chung, S. Kim

    Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: Tolerance induction is considered to be the final goal in the field of organ transplantation. We have performed combined bone marrow and kidney transplantation…
  • 2019 American Transplant Congress

    Prolongation of Allograft Survival via Donor MHC Chimerism Induced by Exosomes

    B. Gonzalez Nolasco1, M. Wang1, W. Orent1, A. Prunevieille1, J. O1, K. Ahrens1, J. C. Madsen2, G. Benichou1

    1Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Achieving robust and durable host immune tolerance of allogeneic transplants is the ultimate goal in clinical transplantation. Mixed chimerism induced via donor bone marrow…
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