2019 American Transplant Congress
Stabilization of Cell Junctions Ameliorates the Effects of Brain Death Induced Acute Lung Injury Post-Transplantation
*Purpose: Donor Brain death (BD) induces acute lung injury (BD-ALI), characterized by the breakdown of endo/epithelial barrier functions. These injuries are further exacerbated by ischemia…2019 American Transplant Congress
Patterns of Rejection in Murine, Porcine, and Human Vascularized Composite Allografts Based on Clinical, Histologic, and Immunohistochemical Analysis
Plastic and Reconstructive Surgery, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: The side effects of chronic immunossupression limit the more extensive use of Vascularized Composite Allotransplantation (VCA), and because reliable pre-clinical animal models will be…2019 American Transplant Congress
Estrogen Mediated Protection in Renal Ischemia Reperfusion Injury (IRI) is Extrinsic to the Kidney
*Purpose: IRI causes morbidity in renal transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required so that strategies…2019 American Transplant Congress
Tolerance Induction by Myeloid Progenitor Cells Modulates T and B Cell Responses
Allergy, Asthma and Immunology, Children's Mercy Hospital, Kansas City, MO
*Purpose: Modulation of the immune system using cellular therapy is an increasingly attractive option to prevent solid organ graft rejection, while at the same time…2019 American Transplant Congress
Sequestration of PLIN2 Regulates High-Fat Diet Induced Metabolic Syndrome and Nonalcoholic Fatty Liver Disease in a Mouse Model of Ischemia Reperfusion Injury
*Purpose: This study aimed to define characteristics and mechanisms leading to nonalcoholic fatty liver disease and metabolic syndrome in a fatty liver mouse model that…2019 American Transplant Congress
Implication of Melanocortin Receptors in Alloimmunity
Transplantation Research Center, Renal, Brigham and Women's Hospital, Boston, MA
*Purpose: Recent studies have indicated the importance of the melanocortin pathway in the regulation of immune responses. In particular, the role that melanocortin receptors (MCRs)…2019 American Transplant Congress
mTOR Inhibitors Enhance Antitumor Activity of Liver Resident NK Cells
Gastroenterology and transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: The immunosuppressive regimen currently used after organ transplantation reduces adaptive components. Therefore, the innate immune cells play pivotal roles in immune surveillance and defense…2019 American Transplant Congress
Lineage Tracing Identifies C-Kit Cells as a Population of Kidney-Specific Stem Cells during Development and in Acute and Chronic Kidney Diseases
*Purpose: We recently reported that c-Kit cells isolated from developing kidneys exhibit regenerative potential in mouse models of acute nephrotic syndrome and ischemia-reperfusion injury. These…2019 American Transplant Congress
Sex Specific Regulation of Podocyte-Specific Genes and Proteins Determines Glomerular Response to mTOR Inhibition
*Purpose: mTOR inhibitors are increasingly used in transplantation with high interindividual variation in proteinuric responses. Although males have higher prevalence and faster progression of glomerular…2019 American Transplant Congress
Treg Suppressor Function within Allografts is Required for Tolerance
Surgery, University of Pittsburgh, Pittsburgh, PA
*Purpose: The role of regulatory CD4+Foxp3+ T cells (Treg) suppressor function within allografts in tolerance remains unclear. Thus, we sought to directly address: 1) whether…
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