2019 American Transplant Congress
The Effects of Anti-BAFF Monoclonal Antibody in the HLA-A2 Sensitized Mouse Model
*Purpose: B-cell activating factor (BAFF) is a cytokine that plays a role in the survival, proliferation and differentiation of B-cells. The aim of this study…2019 American Transplant Congress
BCMA Expression by Alloreactive B Cells Increases during De Novo Alloantibody Responses
Comprehensive Transplant Center, Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: BCMA(TNFRSF17) belongs to tumor necrosis factor receptor superfamily. It is selectively expressed during B/plasma cell differentiation while being nearly absent on naive and memory…2019 American Transplant Congress
In Vivo/In Situ Behaviour of Allogeneic Spleen versus Bone Marrow Cells in Wild-Type Neonatal Mice: Insights into Robust Transplant Tolerance Induction
Pediatrics, University of Alberta, Edmonton, AB, Canada
*Purpose: Comparing the behaviour of fully allogeneic spleen (SC) vs bone marrow cells (BMC) in non-conditioned neonatal mice is important for maximizing synergistic interactions between…2019 American Transplant Congress
Autoantibody Production Significantly Decreased with APRIL/BLyS Blockade in Murine Chronic Rejection Kidney Transplant Model
University of Wisconsin, Madison, WI
*Purpose: Chronic antibody mediated rejection (cAMR) remains a significant barrier to achieving long-term graft survival in kidney transplantation. Alloantibody production from B lymphocytes and plasma…2019 American Transplant Congress
Heterozygous Gene Mutations In The Complement Factor I (cfi) Was Susceptibility Gene For The C3 Glomerulonephritis In Native Kidney And Renal Allograft
*Purpose: We previously reported heterozygous c.848A > G and c.1339C > T gene mutations in the complement factor I (CFI) gene (NM_000204.3) in a kidney transplant recipient with C3…2019 American Transplant Congress
Increased Frequency of Myeloid-Derived Suppressor Cells Contributing to Prolong Skin Allograft Survival in Aged Mice
General Surgery, Chang-gung Hospital, Taoyuan, Taiwan
*Purpose: Currently, aged people are increasing and more and more aged people have organ transplantation. The immunity in aged people is weaker than young people.…2018 American Transplant Congress
Origin and Traffic of Donor-Derived Extracellular Vesicles during Allo-Sensitization
The idea that donor dendritic cells (DCs) transplanted with the grafts and mobilized to draining lymphoid tissues (dLTs) present donor MHC molecules to allo-reactive naïve…2018 American Transplant Congress
Lymphotoxin Beta Receptor Modulation in Lymphatic Endothelial Cells Alters Regulatory T Cell Dynamics
Background:Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels (LV)…2018 American Transplant Congress
The LncRNA MALAT1 Induces Tolerogenic DCs and Antigen Specific Tregs Subsequently Mediating Cardiac Allograft Tolerance in Mice via MiR-155/DC-SIGN/IL10 Axis
Background: Tolerogenic dendritic cells(DCs) by shaping T cells immunity and inducing Tregs play critical roles in the induction of allograft tolerance in transplantation. Long noncoding…2018 American Transplant Congress
In Vivo Imaging and Function of Renal Tertiary Lymphoid Organs
Starzl Transplantation Institute, Pittsburgh.
Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues in the setting of chronic inflammation such as organ transplantation. The function…
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