Articles tagged "Methodology"

2020 American Transplant Congress
Enumeration of Platelets by Flow Cytometry Reveals Human Erythrocyte Fragmentation During Pig Organ Xenoperfusion Studies
Z. Abady¹, K. M. Petitpas¹, L. Burdorf¹, S. G. Pratts¹, B. M. Cerel¹, S. Sendil², M. R. Connolly¹, W. Qin³, Y. Kan³, J. Layer³, M. Youd³, W. Westlin³, L. Yang³, R. N. Pierson III¹, A. M. Azimzadeh¹
¹Surgery, Massachusetts General Hospital and Harvard School of Medicine, Boston, MA, ²Surgery, University of Maryland School of Medicine, Baltimore, MD, ³eGenesis, Cambridge, MA
*Purpose: Human or baboon platelet sequestration and activation occurs during pig organ xenograft perfusion, although the mechanism remains poorly understood. To evaluate an apparent “rebound”…
2020 American Transplant Congress
Microarray and RNA-Seq Analysis of Rejection in Formalin-Fixed Paraffin-Embedded (FFPE) Biopsies: Comparing FFPE to Conventionally Stabilized (RNAlater Solution) Biopsies
P. Halloran¹, K. Famulski¹, J. Reeve¹, J. Huang², N. Alexandrov²
¹University of Alberta, Edmonton, AB, Canada, ²R&D Transplant Diagnostics Division, Thermo Fisher Scientific, Los Angeles, CA
*Purpose: Molecular understanding of organ transplant biopsies requires genome-wide measurements and molecular classifiers. To assess potential of performing molecular diagnostics on formalin-fixed paraffin-embedded (FFPE) biopsies,…
2020 American Transplant Congress
The State of Interventional Clinical Trials in Solid Organ Transplant: Insights from a Systematic Analysis of Clinicaltrials.gov
A. C. Swaminathan¹, J. Li¹, K. Chiswell¹, W. McManigle¹, I. O’Doherty², W. Fitzsimmons³, J. L. Todd¹, S. Tibbs⁴, S. M. Palmer¹
¹Duke Clinical Research Institute, Durham, NC, ²Critical Path Institute, Tuscan, AZ, ³Fitzsimmons LLC, Chicago, IL, ⁴Duke University, Durham, NC
*Purpose: The approach to immunosuppression after solid organ transplant has remained relatively unchanged for almost 20 years, despite the high prevalence of immunosuppression-related complications and…
2020 American Transplant Congress
Challenges in Examining Transplant Outcomes in Patients with Fontan-Associated Liver Disease
R. T. Fischer¹, M. H. Kim², A. Nguyen³, S. R. Kumar³, J. Bucuvalas⁴, E. F. Glynn¹, M. A. Hoffman¹, J. Emamaullee³
¹Children's Mercy Hospital, Kansas City, MO, ²Children's Hospital-Los Angeles, Los Angeles, CA, ³University of Southern California, Los Angeles, CA, ⁴Mount Sinai Kravis Children's Hospital, New York, NY
*Purpose: The Fontan procedure has allowed patients born with single ventricle physiology to survive into adulthood. It is projected that the mean age of Fontan…
2020 American Transplant Congress
Patient-Informed Design of an Educational Website on Living Kidney Donation
M. Keller¹, R. Seibert¹, T. Feeley², L. Kayler¹
¹Erie County Medical Center, Buffalo, NY, ²University at Buffalo, SUNY, Buffalo, NY
*Purpose: Web-based education may be a powerful tool to support kidney patients’ learning about living kidney donation (LKD); however, websites that are not user-friendly can…
2019 American Transplant Congress
Proteomics Reveals Molecular Window and Metabolism of Normothermically Perfused Human Kidneys
A. Weissenbacher¹, H. Huang², A. Thorne³, L. M. Lo Faro³, J. Hunter³, R. Ploeg³, C. C. Coussios⁴, P. J. Friend³, B. Kessler⁵
¹Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria, ²Nuffield Department o Medicine, Target Discovery Institute, University of Oxford, Oxford, United Kingdom, ³Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ⁴Oxford Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ⁵Nuffield Department o Medicine, Target Discovery Instituteiscovery Institute, University of Oxford, Oxford, United Kingdom
*Purpose: We have shown that 24h normothermic kidney perfusion (NKP) with urine recirculation (URC) is superior to non URC for maintaining homeostasis previously. However, the…
2019 American Transplant Congress
Modeling Patients as Dynamical Systems: Evaluating the Efficiency of Kidney Transplantation through Multi-Stage Data Envelopment Analysis
F. J. Santos Arteaga¹, D. Di Caprio², D. Cucchiari³, J. M. Campistol³, F. Oppenheimer³, F. Diekmann³, I. Revuelta³
¹Faculty of Economics and Management, Free University of Bolzano, Bolzano, Italy, ²Department of Mathematics and Statistics, York University, Toronto, ON, Canada, ³Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain
*Purpose: The occurrence of kidney graft loss is determined by a large set of variables interacting across the different stages of the transplantation process. This…
2019 American Transplant Congress
Interpretable Post-Transplant Graft Failure Prediction Using Decision Tree Neural Networks
J. N. Valdez¹, T. Fu¹, J. Hogan², S. Adhikary¹, M. Arenson², R. Zhang², X. Zhang³, K. Li², A. B. Adams², R. E. Patzer², J. Sun¹
¹Georgia Institute of Technology, Atlanta, GA, ²Emory University, Atlanta, GA, ³University of Michigan, Ann Arbor, MI
*Purpose: Various predictive models identify kidney transplant (KTx) recipients at high risk of graft failure (GF), but comparisons across statistical approaches for a full range…
2019 American Transplant Congress
Predicting Post Liver Transplant 30-Day Readmission Using Deep Neural Network Model
S. K. Niazi¹, H. O. Park², R. E. Carter³, A. Keaveny⁴, T. Schneekloth⁵, A. Spaulding⁶, D. Harnois⁴, P. F. Moreno-Franco⁷, E. Vargas⁶, T. Rummans¹, C. Taner⁷
¹Psychiatry & Psychology, Mayo Clinic, Jacksonville, FL, ²Enterprise Analytics, Mayo Clinic, Rochester, MN, ³Health Sciences Research, Mayo Clinic, Jacksonville, FL, ⁴GI & Hepatology, Mayo Clinic, Jacksonville, FL, ⁵Psychiatry & Psychology, Mayo Clinic, Rochester, MN, ⁶Health Services Research, Mayo Clinic, Jacksonville, FL, ⁷Transplantation, Mayo Clinic, Jacksonville, FL
*Purpose: Liver transplantation (LT) is a complex, expensive process and requires multidisciplinary care. A significant portion of the estimated $735,000 LT cost can be attributed…
2019 American Transplant Congress
Liver Waitlist Dropout and Transplant Rates for Metropolitan vs. Non-Metropolitan Candidates
D. Schladt¹, T. Weaver¹, J. Pyke¹, A. Herreid¹, B. Thompson¹, B. Kasiske¹, J. Snyder¹, W. Kim², J. Lake³, A. Israni¹
¹SRTR, Minneapolis, MN, ²Stanford Univ, Stanford, CA, ³Univ of Minnesota, Minneapolis, MN
*Purpose: Rural candidates may be disadvantaged on the liver waiting list. We evaluated rates and hazards of waitlist dropout and transplant by urbanicity.*Methods: We selected…