ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Methodology"

  • 2020 American Transplant Congress

    Mass Cytometry-Based Immunoprofiling as a Tool to Predict Rejection in a Large Cohort of Pediatric Transplant Recipients

    M. Rao1, J. T. Harden2, M. Lapasaran2, C. O. Esquivel3, O. M. Martinez2, S. M. Krams2

    1Pediatrics, Stanford University, Palo Alto, CA, 2Stanford University School of Medicine, Stanford, CA, 3Surgery and Pediatrics, Stanford University School of Medicine, Stanford, CA

    *Purpose: Rejection remains a serious problem in the pediatric transplant population. Early detection remains a challenge; furthermore, the changes in immune makeup which accompany rejection…
  • 2020 American Transplant Congress

    Improved Medication Safety Outcomes with a Mobile Health, Pharmacist-Led Intervention: Results of the TRANSAFE Rx Randomized Controlled Trial

    H. Gonzales, J. Fleming, M. Gebregziabher, J. McGillicuddy, D. Taber

    MUSC, Charleston, SC

    *Purpose: Medication (med) safety events are a predominant cause of poor health outcomes, particularly within high-risk groups such as kidney transplant (KTX) recipients. The primary…
  • 2020 American Transplant Congress

    Quantifying Gender-Based Disparties in Liver Allocation: A Path Forward

    B. A. Shelton1, K. Olthoff2, E. Pomfret3, K. A. Forde2, D. Sawinski4, M. Gray1, N. Ascher5, J. E. Locke1

    1University of Alabama at Birmingham, Birmingham, AL, 2University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 3University of Colorado School of Medicine, Denver, CO, 4University of Pennsylvania, Philadelphia, PA, 5University of California at San Francisco School of Medicine, San Francisco, CA

    *Purpose: Differences in local organ supply and demand have introduced geographic inequities in the Model for End-stage Liver Disease (MELD) based liver allocation system prompting…
  • 2020 American Transplant Congress

    microPOTS: A New Single Cell Proteomic Method for Profiling Human Kidney Transplant Biopsy Tissue

    T. Sigdel1, P. Piehowski2, S. Roy1, J. Liberto1, A. Schroeder1, P. Rashmi1, S. Sur1, I. Damm1, W. Qian2, M. M. Sarwal1

    1University of California San Francisco, San Francisco, CA, 2Pacific Northwest National Laboratory, Richland, WA

    *Purpose: The purpose of this study was to interrogate acute rejection (AR) in the renal allograft at single cell level. Despite advances in single cell…
  • 2020 American Transplant Congress

    The Centers for Medicare and Medicaid Services’ Proposed Metrics for Recertification of Organ Procurement Organizations: Evaluation by the Scientific Registry of Transplant Recipients

    J. Snyder1, D. Musgrove1, D. Zaun1, A. Wey1, N. Salkowski1, J. Rosendale2, A. Israni1, R. Hirose3, B. Kasiske1

    1SRTR, Minneapolis, MN, 2UNOS, Richmond, VA, 3Department of Surgery, Univ of California, San Francisco, San Francisco, CA

    *Purpose: On December 23, 2019, the US Centers for Medicare and Medicaid Services proposed two new standards that organ procurement organizations (OPOs) must meet for…
  • 2020 American Transplant Congress

    Mass-Spectrometry Based Discovery of Tubular Injury Marker in Chronic Kidney Disease

    J. Kim1, D. Han1, J. Jeong2, J. Moon1, S. Lee3, Y. Kim1, K. Yoo4, D. Kim1, Y. Kim1, S. Yang1

    1Seoul National University Hospital, Seoul, Korea, Republic of, 2Veterans Health Service Medical Center, Seoul, Korea, Republic of, 3Kangwon National University Hospital, Kangwon-do, Korea, Republic of, 4Ulsan National University Hospital, Ulsan, Korea, Republic of

    *Purpose: Renal tubular injury and interstitial fibrosis are inevitable processes in the progression of chronic kidney disease (CKD). The purpose of this study is to…
  • 2020 American Transplant Congress

    Enumeration of Platelets by Flow Cytometry Reveals Human Erythrocyte Fragmentation During Pig Organ Xenoperfusion Studies

    Z. Abady1, K. M. Petitpas1, L. Burdorf1, S. G. Pratts1, B. M. Cerel1, S. Sendil2, M. R. Connolly1, W. Qin3, Y. Kan3, J. Layer3, M. Youd3, W. Westlin3, L. Yang3, R. N. Pierson III1, A. M. Azimzadeh1

    1Surgery, Massachusetts General Hospital and Harvard School of Medicine, Boston, MA, 2Surgery, University of Maryland School of Medicine, Baltimore, MD, 3eGenesis, Cambridge, MA

    *Purpose: Human or baboon platelet sequestration and activation occurs during pig organ xenograft perfusion, although the mechanism remains poorly understood. To evaluate an apparent “rebound”…
  • 2020 American Transplant Congress

    Microarray and RNA-Seq Analysis of Rejection in Formalin-Fixed Paraffin-Embedded (FFPE) Biopsies: Comparing FFPE to Conventionally Stabilized (RNAlater Solution) Biopsies

    P. Halloran1, K. Famulski1, J. Reeve1, J. Huang2, N. Alexandrov2

    1University of Alberta, Edmonton, AB, Canada, 2R&D Transplant Diagnostics Division, Thermo Fisher Scientific, Los Angeles, CA

    *Purpose: Molecular understanding of organ transplant biopsies requires genome-wide measurements and molecular classifiers. To assess potential of performing molecular diagnostics on formalin-fixed paraffin-embedded (FFPE) biopsies,…
  • 2020 American Transplant Congress

    The State of Interventional Clinical Trials in Solid Organ Transplant: Insights from a Systematic Analysis of Clinicaltrials.gov

    A. C. Swaminathan1, J. Li1, K. Chiswell1, W. McManigle1, I. O’Doherty2, W. Fitzsimmons3, J. L. Todd1, S. Tibbs4, S. M. Palmer1

    1Duke Clinical Research Institute, Durham, NC, 2Critical Path Institute, Tuscan, AZ, 3Fitzsimmons LLC, Chicago, IL, 4Duke University, Durham, NC

    *Purpose: The approach to immunosuppression after solid organ transplant has remained relatively unchanged for almost 20 years, despite the high prevalence of immunosuppression-related complications and…
  • 2020 American Transplant Congress

    Challenges in Examining Transplant Outcomes in Patients with Fontan-Associated Liver Disease

    R. T. Fischer1, M. H. Kim2, A. Nguyen3, S. R. Kumar3, J. Bucuvalas4, E. F. Glynn1, M. A. Hoffman1, J. Emamaullee3

    1Children's Mercy Hospital, Kansas City, MO, 2Children's Hospital-Los Angeles, Los Angeles, CA, 3University of Southern California, Los Angeles, CA, 4Mount Sinai Kravis Children's Hospital, New York, NY

    *Purpose: The Fontan procedure has allowed patients born with single ventricle physiology to survive into adulthood. It is projected that the mean age of Fontan…
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