Articles tagged "Methodology"

2020 American Transplant Congress
Mass-Spectrometry Based Discovery of Tubular Injury Marker in Chronic Kidney Disease
J. Kim¹, D. Han¹, J. Jeong², J. Moon¹, S. Lee³, Y. Kim¹, K. Yoo⁴, D. Kim¹, Y. Kim¹, S. Yang¹
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Veterans Health Service Medical Center, Seoul, Korea, Republic of, ³Kangwon National University Hospital, Kangwon-do, Korea, Republic of, ⁴Ulsan National University Hospital, Ulsan, Korea, Republic of
*Purpose: Renal tubular injury and interstitial fibrosis are inevitable processes in the progression of chronic kidney disease (CKD). The purpose of this study is to…
2020 American Transplant Congress
Enumeration of Platelets by Flow Cytometry Reveals Human Erythrocyte Fragmentation During Pig Organ Xenoperfusion Studies
Z. Abady¹, K. M. Petitpas¹, L. Burdorf¹, S. G. Pratts¹, B. M. Cerel¹, S. Sendil², M. R. Connolly¹, W. Qin³, Y. Kan³, J. Layer³, M. Youd³, W. Westlin³, L. Yang³, R. N. Pierson III¹, A. M. Azimzadeh¹
¹Surgery, Massachusetts General Hospital and Harvard School of Medicine, Boston, MA, ²Surgery, University of Maryland School of Medicine, Baltimore, MD, ³eGenesis, Cambridge, MA
*Purpose: Human or baboon platelet sequestration and activation occurs during pig organ xenograft perfusion, although the mechanism remains poorly understood. To evaluate an apparent “rebound”…
2020 American Transplant Congress
Microarray and RNA-Seq Analysis of Rejection in Formalin-Fixed Paraffin-Embedded (FFPE) Biopsies: Comparing FFPE to Conventionally Stabilized (RNAlater Solution) Biopsies
P. Halloran¹, K. Famulski¹, J. Reeve¹, J. Huang², N. Alexandrov²
¹University of Alberta, Edmonton, AB, Canada, ²R&D Transplant Diagnostics Division, Thermo Fisher Scientific, Los Angeles, CA
*Purpose: Molecular understanding of organ transplant biopsies requires genome-wide measurements and molecular classifiers. To assess potential of performing molecular diagnostics on formalin-fixed paraffin-embedded (FFPE) biopsies,…
2020 American Transplant Congress
The State of Interventional Clinical Trials in Solid Organ Transplant: Insights from a Systematic Analysis of Clinicaltrials.gov
A. C. Swaminathan¹, J. Li¹, K. Chiswell¹, W. McManigle¹, I. O’Doherty², W. Fitzsimmons³, J. L. Todd¹, S. Tibbs⁴, S. M. Palmer¹
¹Duke Clinical Research Institute, Durham, NC, ²Critical Path Institute, Tuscan, AZ, ³Fitzsimmons LLC, Chicago, IL, ⁴Duke University, Durham, NC
*Purpose: The approach to immunosuppression after solid organ transplant has remained relatively unchanged for almost 20 years, despite the high prevalence of immunosuppression-related complications and…
2020 American Transplant Congress
Challenges in Examining Transplant Outcomes in Patients with Fontan-Associated Liver Disease
R. T. Fischer¹, M. H. Kim², A. Nguyen³, S. R. Kumar³, J. Bucuvalas⁴, E. F. Glynn¹, M. A. Hoffman¹, J. Emamaullee³
¹Children's Mercy Hospital, Kansas City, MO, ²Children's Hospital-Los Angeles, Los Angeles, CA, ³University of Southern California, Los Angeles, CA, ⁴Mount Sinai Kravis Children's Hospital, New York, NY
*Purpose: The Fontan procedure has allowed patients born with single ventricle physiology to survive into adulthood. It is projected that the mean age of Fontan…
2020 American Transplant Congress
Patient-Informed Design of an Educational Website on Living Kidney Donation
M. Keller¹, R. Seibert¹, T. Feeley², L. Kayler¹
¹Erie County Medical Center, Buffalo, NY, ²University at Buffalo, SUNY, Buffalo, NY
*Purpose: Web-based education may be a powerful tool to support kidney patients’ learning about living kidney donation (LKD); however, websites that are not user-friendly can…
2020 American Transplant Congress
Mass Cytometry-Based Immunoprofiling as a Tool to Predict Rejection in a Large Cohort of Pediatric Transplant Recipients
M. Rao¹, J. T. Harden², M. Lapasaran², C. O. Esquivel³, O. M. Martinez², S. M. Krams²
¹Pediatrics, Stanford University, Palo Alto, CA, ²Stanford University School of Medicine, Stanford, CA, ³Surgery and Pediatrics, Stanford University School of Medicine, Stanford, CA
*Purpose: Rejection remains a serious problem in the pediatric transplant population. Early detection remains a challenge; furthermore, the changes in immune makeup which accompany rejection…
2020 American Transplant Congress
Improved Medication Safety Outcomes with a Mobile Health, Pharmacist-Led Intervention: Results of the TRANSAFE Rx Randomized Controlled Trial
H. Gonzales, J. Fleming, M. Gebregziabher, J. McGillicuddy, D. Taber
MUSC, Charleston, SC
*Purpose: Medication (med) safety events are a predominant cause of poor health outcomes, particularly within high-risk groups such as kidney transplant (KTX) recipients. The primary…
2019 American Transplant Congress
Liver Waitlist Dropout and Transplant Rates for Metropolitan vs. Non-Metropolitan Candidates
D. Schladt¹, T. Weaver¹, J. Pyke¹, A. Herreid¹, B. Thompson¹, B. Kasiske¹, J. Snyder¹, W. Kim², J. Lake³, A. Israni¹
¹SRTR, Minneapolis, MN, ²Stanford Univ, Stanford, CA, ³Univ of Minnesota, Minneapolis, MN
*Purpose: Rural candidates may be disadvantaged on the liver waiting list. We evaluated rates and hazards of waitlist dropout and transplant by urbanicity.*Methods: We selected…
2019 American Transplant Congress
The C-Statistic Provides No Information on the Accuracy of Program Evaluations or the Presence of Unmeasured Confounders
A. Wey, N. Salkowski, B. Kasiske, M. Skeans, S. Gustafson, A. Israni, J. Snyder
SRTR, Minneapolis, MN
*Purpose: The C-statistic of risk-adjustment models is regularly used to assess accuracy of program evaluations or determine presence of unmeasured confounding. However, the C-statistic depends…