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American Transplant Congress abstracts

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Articles tagged "Metabolic disease"

  • 2022 American Transplant Congress

    Novel Drug Target Identified for Reversal of Renal Tubular Injury

    S. Sur, M. Kerwin, S. Pineda, M. Sarwal

    UCSF, San Francisco, CA

    *Purpose: Understanding the unique susceptibility of the human kidney tubule to oxidative cell stress and to identify compounds to support reversal of renal tubular damage.*Methods:…
  • 2022 American Transplant Congress

    Living Related Liver Transplantation for Children with Metabolic Diseases- The Earlier the Better

    M. Schulze, A. Aldana, M. Shagrani, D. D. Broering

    Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

    *Purpose: Metabolic defects in children are rare throughout the world, however if diagnosed too late they can cause severe neurological irreversible deterioration, eventually being fatal.…
  • 2021 American Transplant Congress

    State-level Trend in the Prevalence of Non-alcoholic Steatohepatitis for Liver Transplant Candidates in the United States, 2001-2017

    S. Chang1, M. Wang1, M. Pozo2, D. Ladner2, D. Borja-Cacho2

    1Washington University School of Medicine, Saint Louis, MO, 2Northwestern University, Chicago, IL

    *Purpose: As variation in the prevalence of obesity across states continues to grow, the prevalence of nonalcoholic steatohepatitis (NASH) is also rising. However, little is…
  • 2021 American Transplant Congress

    Taurodeoxycholic Acid and L-valine Ameliorate Macrophage Driven Alloimmunity in Obese Transplant Recipients

    M. Quante1, J. Iske1, D. Perkins2, M. Alegre3, H. Zhou1, A. Elkhal1, S. G. Tullius1

    1Department of Surgery, Brigham and Women's Hospital, Boston, MA, 2University of Illinois at Chicago, Chicago, IL, 3Department of Medicine, The University of Chicago, Chicago, IL

    *Purpose: Obesity initiates a chronic inflammatory network linked to more frequent perioperative complications and increased acute rejection rates after organ transplantation. Clinically, morbidly obese transplant…
  • 2021 American Transplant Congress

    Mitochondrial Transplant Minimizes Liver Ischemia Reperfusion Injury in Lean and Obese Mice

    C. Watkins1, G. Lamanilao1, C. Kuscu1, C. Kuscu1, J. F. Pierre2, J. Eason1, A. Bajwa1

    1Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, 2Department of Pediatrics - Divisions of Neonatology and Pediatric Obesity, The University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Ischemia induces altered bioenergetics within cells with increased mitochondrial swelling and reactive oxygen species and that ultimately degrade of cellular function. Ischemia reperfusion injury…
  • 2021 American Transplant Congress

    Superior Metabolic Function of Type 2 Diabetes Mellitus Patients After Simultaneous Kidney/pancreas Transplantation Compared with Kidney Transplantation Alone

    X. Y. Fu, C. Yu, H. Wang, J. Zhao, Z. Wang, C. Mo, X. Shi, G. Feng, W. Song, Z. Shen

    Tianjin First Centeral Hospital, Tianjin, China

    *Purpose: To compare the renal function, metabolic profiles and survival outcomes of simultaneous pancreas kidney transplantation (SPK) and kidney transplantation alone (KTA) to end-stage renal…
  • 2021 American Transplant Congress

    A Pediatric Liver Allograft with an Occult Urea Cycle Defect Carrier Mutation Causing Delayed Graft Function and Metabolic Crisis After Liver Transplantation

    A. Peters, M. Rezvani, C. Prada, K. Campbell

    Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    *Purpose: We report an interesting case of delayed graft function following pediatric liver transplantation, which was attributed to previously unrecognized urea cycle carrier genetic defect…
  • 2020 American Transplant Congress

    Sleeve Gastrectomy Compared with Gastric Bypass for Morbidly Obese Liver Transplant Candidates: A Decision Analysis

    R. A. Choudhury1, D. Yoeli1, G. Hoeltzel2, H. B. Moore1, H. Yaffe1, K. R. Dumon3, N. N. Williams3, P. L. Abt4, K. D. Conzen1, J. J. Pomposelli1, E. A. Pomfret1, T. L. Nydam1

    1Department of Surgery- Division of Transplantation Surgery, University of Colorado Hospital, Aurora, CO, 2Thomas Jefferson University Hospital, Philadelphia, PA, 3Department of Surgery, University of Pennsylvania Hospital, Philadelphia, PA, 4Department of Surgery- Division of Transplantation Surgery, University of Pennsylvania Hospital, Philadelphia, PA

    *Purpose: The use of bariatric surgery has increased for morbidly obese liver transplant candidates for whom placement on the waitlist is often restricted until they…
  • 2020 American Transplant Congress

    Long Term Outcome of Patients Transplanted for Non Alcoholic Steatohepatitis Related Cirrhosis

    W. Alhamoudi1, I. Salih2, S. Yousif2, M. Shawkat3, K. Bzeizi2, S. Alghamdi2, A. Albenmousa2, D. Broering2

    1Medicine, King Saud University, Riyadh, Saudi Arabia, 2Liver Transplant, King Faisal Specialist Hospital, Riyadh, Saudi Arabia, 3Internal Medicine, Minia University, Minia, Egypt

    *Purpose: Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease worldwide. Cirrhosis secondary to Nonalcoholic Steatohepatitis (NASH) is projected to…
  • 2020 American Transplant Congress

    Progression of Insulin Resistance after Liver Transplantation – Prospective Study

    I. Mikova1, D. Erhartova1, K. Dvorakova1, P. Sedivy2, M. Drobny2, M. Dezortova2, M. Hajek2, M. Cahová3, H. Dankova3, E. Sticova4, V. Lanska5, P. Trunecka1

    1Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 3Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 4Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 5Medical Statistics Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

    *Purpose: Insulin resistance (IR) plays an important role in pathogenesis of nonalcoholic fatty liver disease (NAFLD) and other diseases. The data about prevalence and evolution…
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