ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Metabolic disease"

  • 2022 American Transplant Congress

    Safety and Efficacy of GLP-1 Agonists in Solid Organ Transplant Recipients

    E. Heiman, D. Blanco, A. Webb

    Pharmacy, Tampa General Hospital, Tampa, FL

    *Purpose: Glucagon-like peptide-1 receptor agonists (GLP-1 RA) have been shown to improve glycemic control, obesity, and cardiovascular disease in the general population. The safety and…
  • 2022 American Transplant Congress

    Development and Validation of a Medication Safety Dashboard in Veteran Transplant Recipients: Preliminary Results of a Multicenter Cluster-Randomized Controlled Clinical Trial

    D. Taber1, R. Felkner2, K. Rife3, D. Cooney3, S. Laforest3, E. Santa4, N. Super5, C. Hall6, T. Goddard1, R. Alexander1

    1MUSC, Charleston, SC, 2Madison VA, Madison, WI, 3Cleveland VA, Cleveland, OH, 4Atlanta VA, Atlanta, GA, 5Chicago VA, Chicago, IL, 6Charleston VA, Charleston, SC

    *Purpose: In organ transplant, med errors, adverse drug events, and nonadherence lead to increased healthcare utilization and graft loss. Veterans with transplants are a high-risk…
  • 2021 American Transplant Congress

    State-level Trend in the Prevalence of Non-alcoholic Steatohepatitis for Liver Transplant Candidates in the United States, 2001-2017

    S. Chang1, M. Wang1, M. Pozo2, D. Ladner2, D. Borja-Cacho2

    1Washington University School of Medicine, Saint Louis, MO, 2Northwestern University, Chicago, IL

    *Purpose: As variation in the prevalence of obesity across states continues to grow, the prevalence of nonalcoholic steatohepatitis (NASH) is also rising. However, little is…
  • 2021 American Transplant Congress

    Taurodeoxycholic Acid and L-valine Ameliorate Macrophage Driven Alloimmunity in Obese Transplant Recipients

    M. Quante1, J. Iske1, D. Perkins2, M. Alegre3, H. Zhou1, A. Elkhal1, S. G. Tullius1

    1Department of Surgery, Brigham and Women's Hospital, Boston, MA, 2University of Illinois at Chicago, Chicago, IL, 3Department of Medicine, The University of Chicago, Chicago, IL

    *Purpose: Obesity initiates a chronic inflammatory network linked to more frequent perioperative complications and increased acute rejection rates after organ transplantation. Clinically, morbidly obese transplant…
  • 2021 American Transplant Congress

    Mitochondrial Transplant Minimizes Liver Ischemia Reperfusion Injury in Lean and Obese Mice

    C. Watkins1, G. Lamanilao1, C. Kuscu1, C. Kuscu1, J. F. Pierre2, J. Eason1, A. Bajwa1

    1Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, 2Department of Pediatrics - Divisions of Neonatology and Pediatric Obesity, The University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Ischemia induces altered bioenergetics within cells with increased mitochondrial swelling and reactive oxygen species and that ultimately degrade of cellular function. Ischemia reperfusion injury…
  • 2021 American Transplant Congress

    Superior Metabolic Function of Type 2 Diabetes Mellitus Patients After Simultaneous Kidney/pancreas Transplantation Compared with Kidney Transplantation Alone

    X. Y. Fu, C. Yu, H. Wang, J. Zhao, Z. Wang, C. Mo, X. Shi, G. Feng, W. Song, Z. Shen

    Tianjin First Centeral Hospital, Tianjin, China

    *Purpose: To compare the renal function, metabolic profiles and survival outcomes of simultaneous pancreas kidney transplantation (SPK) and kidney transplantation alone (KTA) to end-stage renal…
  • 2021 American Transplant Congress

    A Pediatric Liver Allograft with an Occult Urea Cycle Defect Carrier Mutation Causing Delayed Graft Function and Metabolic Crisis After Liver Transplantation

    A. Peters, M. Rezvani, C. Prada, K. Campbell

    Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    *Purpose: We report an interesting case of delayed graft function following pediatric liver transplantation, which was attributed to previously unrecognized urea cycle carrier genetic defect…
  • 2020 American Transplant Congress

    Assessment of Sarcopenia and Obesity by Bioelectrical Impedance Analysis in Transplant and Hepatobiliary Populations

    J. Konel1, T. Kitajima2, L. Arevalo1, N. Murray1, T. Pietrowsky2, D. Venkat2, H. Gonzalez2, M. Samaniego2, M. Abouljoud2, S. Nagai2

    1Wayne State University School of Medicine, Detroit, MI, 2Henry Ford Transplant Institute, Detroit, MI

    *Purpose: Sarcopenia and obesity are common among transplant and hepatobiliary patients; however, current methods of measuring these risk factors may provide an inadequate representation of…
  • 2020 American Transplant Congress

    Selectively Transplanting Moderately to Severely Macrosteatotic Grafts: Does Recipient Metabolic Environment Affect Outcomes?

    P. J. Altshuler, A. Rios Diaz, O. Shaheen, A. P. Shah, W. R. Maley, A. Frank, C. Ramirez, J. Glorioso, H. Dang, A. S. Bodzin

    Department of Surgery, Thomas Jefferson University, Philadelphia, PA

    *Purpose: As incidence of Non-Alcoholic Steatohepatitis (NASH) cirrhosis rises, organ utilization remains stagnant. Recently, it has been shown that selective utilization of >30% macrosteatotic grafts…
  • 2020 American Transplant Congress

    Pediatric Liver Transplantation for Metabolic Liver Diseases versus Biliary Atresia: Single Center Experience

    A. M. Elsabbagh, K. M. Khan, A. A. Amin, S. S. Kaufman, N. A. Yazigi, T. M. Fishbein

    MedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC

    *Purpose: The main indication for LT in children has been biliary atresia (BA). Recent advances in surgical management and the development of new immunosuppressants have…
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