2022 American Transplant Congress
Novel Drug Target Identified for Reversal of Renal Tubular Injury
*Purpose: Understanding the unique susceptibility of the human kidney tubule to oxidative cell stress and to identify compounds to support reversal of renal tubular damage.*Methods:…2022 American Transplant Congress
Living Related Liver Transplantation for Children with Metabolic Diseases- The Earlier the Better
*Purpose: Metabolic defects in children are rare throughout the world, however if diagnosed too late they can cause severe neurological irreversible deterioration, eventually being fatal.…2021 American Transplant Congress
Taurodeoxycholic Acid and L-valine Ameliorate Macrophage Driven Alloimmunity in Obese Transplant Recipients
*Purpose: Obesity initiates a chronic inflammatory network linked to more frequent perioperative complications and increased acute rejection rates after organ transplantation. Clinically, morbidly obese transplant…2021 American Transplant Congress
Mitochondrial Transplant Minimizes Liver Ischemia Reperfusion Injury in Lean and Obese Mice
*Purpose: Ischemia induces altered bioenergetics within cells with increased mitochondrial swelling and reactive oxygen species and that ultimately degrade of cellular function. Ischemia reperfusion injury…2021 American Transplant Congress
Superior Metabolic Function of Type 2 Diabetes Mellitus Patients After Simultaneous Kidney/pancreas Transplantation Compared with Kidney Transplantation Alone
Tianjin First Centeral Hospital, Tianjin, China
*Purpose: To compare the renal function, metabolic profiles and survival outcomes of simultaneous pancreas kidney transplantation (SPK) and kidney transplantation alone (KTA) to end-stage renal…2021 American Transplant Congress
A Pediatric Liver Allograft with an Occult Urea Cycle Defect Carrier Mutation Causing Delayed Graft Function and Metabolic Crisis After Liver Transplantation
Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: We report an interesting case of delayed graft function following pediatric liver transplantation, which was attributed to previously unrecognized urea cycle carrier genetic defect…2021 American Transplant Congress
State-level Trend in the Prevalence of Non-alcoholic Steatohepatitis for Liver Transplant Candidates in the United States, 2001-2017
1Washington University School of Medicine, Saint Louis, MO, 2Northwestern University, Chicago, IL
*Purpose: As variation in the prevalence of obesity across states continues to grow, the prevalence of nonalcoholic steatohepatitis (NASH) is also rising. However, little is…2020 American Transplant Congress
Impact of Dialysis and Diabetes on Survival in Recipients of Combined Heart-Kidney Transplant
*Purpose: Mounting data shows a survival benefit of combined heart-kidney transplantation in patients with heart and renal failure. However, little has been done to understand…2020 American Transplant Congress
Intravenous Administration of Mitochondria Minimizes Liver Ischemia Reperfusion Injury in Lean and Diet Induced Obese Mice
*Purpose: Ischemia induces altered bioenergetics within cells with increased mitochondrial swelling and reactive oxygen species and that ultimately degrade of cellular function. Ischemia reperfusion injury…2020 American Transplant Congress
Long-Term Metabolic Control and Health Outcomes in Maple Syrup Urine Disease Following Liver Transplantation in Children and Young Adults
*Purpose: Determine outcomes and branch-chain amino acid (BCAA - leucine [LEU], isoleucine [ISO], and valine [VAL]) levels at 1-3, 4-7, and 8-10 years for patient’s…
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