The Impact of Preoperative Glucose Intolerance and Hypertension on the Living Kidney Donors
T. Hiramitsu1, T. Tomosugi1, K. Futamura1, M. Okada1, N. Goto1, S. Narumi1, K. Uchida2, Y. Watarai1
1Department of Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya Aichi, Japan, 2Department of Transplant Surgery, Masuko Memorial Hospital, Nagoya Aichi, Japan
Meeting: 2020 American Transplant Congress
Abstract number: C-074
Keywords: Donors, marginal, Glomerular filtration rate (GFR), Living donor, Metabolic disease
Session Information
Session Name: Poster Session C: Kidney Living Donor: Long Term Outcomes
Session Type: Poster Session
Date: Saturday, May 30, 2020
Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
Location: Virtual
*Purpose: Recently the mortality of living kidney donors was demonstrated to be significantly worse than that of healthy general population. However, the impact of preoperative comorbidities of living kidney donors were not assessed properly. We investigated the impact of preoperative glucose intolerance and hypertension on the living kidney donors.
*Methods: 802 out of 807 living kidney donors who underwent donor nephrectomy between January 2008 and December 2016 and were followed up more than 5 months after operation were enrolled in this study. Preoperative comorbidities included hypertension, dyslipidemia, glucose intolerance, and obesity. Postoperative estimated glomerular filtration rate (eGFR) and mortality of living kidney donors with both glucose intolerance and hypertension were compared with those of healthy living kidney donors without preoperative comorbidities using linear mixed model analysis and log-rank tests.
*Results: Delta eGFRs of living kidney donors with both glucose intolerance and hypertension in every time point demonstrated to be similar to those in healthy living kidney donors without pre-operative comorbidities (Figure 1).
Log-rank tests stratified by age (≥60 years or <60 years) and sex showed no significant difference in mortality between 2 groups (Figure 2).
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*Conclusions: The postoperative eGFR and mortality of living kidney donors with both glucose intolerance and hypertension were similar to those of healthy living kidney donors without preoperative comorbidities when followed up properly after operation.
To cite this abstract in AMA style:
Hiramitsu T, Tomosugi T, Futamura K, Okada M, Goto N, Narumi S, Uchida K, Watarai Y. The Impact of Preoperative Glucose Intolerance and Hypertension on the Living Kidney Donors [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/the-impact-of-preoperative-glucose-intolerance-and-hypertension-on-the-living-kidney-donors/. Accessed October 10, 2024.« Back to 2020 American Transplant Congress