Articles tagged "Lung"

2022 American Transplant Congress
Donor-Derived Cell-Free DNA Across the Spectrum of Solid Organ Transplantation
S. R. Potter¹, J. Miles², K. Qu², R. Woodward², S. Dholakia²
¹Baylor Scott & White Health, Temple, TX, ²CareDx, Inc, Brisbane, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a robust and clinically useful analyte initially validated for kidney allograft surveillance. Emerging data support the utility of dd-cfDNA…
2022 American Transplant Congress
Dynamic Changes and Roles of Specialized Pro-resolving Lipid Meditators in the Initiation and Resolution Process of Lung Ischemia-Reperfusion Injury in Rats
H. Oda¹, S. Tanaka¹, M. Shinohara², Y. Morimura¹, Y. Yokoyama¹, H. Kayawake¹, Y. Yamada¹, A. Ohsumi¹, D. Nakajima¹, H. Date¹
¹Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto City, Japan, ²The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, Kobe City, Japan
*Purpose: Lung ischemia-reperfusion injury (IRI) is one of the significant complications after lung transplantation, which is a form of acute lung injury by robust inflammation.…
2022 American Transplant Congress
A Model of Idiopathic Pneumonia Syndrome in Rhesus Macaques
R. S. Bermea¹, K. Ingersoll², L. P. Hariri³, M. Warren², L. Kean², V. Tkachev²
¹Pulmonary & Critical Care Medicine, Massachusetts General Hospital, Boston, MA, ²Hematology/Oncology, Boston Children's Hospital, Boston, MA, ³Pathology, Massachusetts General Hospital, Boston, MA
*Purpose: To create a model of idiopathic pneumonia syndrome (IPS), a deadly complication of hematopoietic stem cell transplantation (HSCT) in Rhesus macaques (RM).*Methods: RM were…
2022 American Transplant Congress
Infection Impacts dd-cfDNA in Lung Transplant Recipients
D. Levine¹, C. Giner¹, C. Pham², R. Woodward², A. Roux³
¹University of Texas Health System San Antonio, San Antonio, TX, ²CareDX, South San Francisco, CA, ³Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France
*Purpose: Infection is the leading cause of death within 1 year post lung transplant. Graft injury secondary to infection is affected by both source and…
2022 American Transplant Congress
Residential Mobility of Lung Recipients
W. M. Tsuang¹, E. Jiang¹, J. Curtis²
¹Cleveland Clinic, Cleveland, OH, ²Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH
*Purpose: The Final Rule from the U.S. Department of Health and Human Services mandates that patient geography should have a minimal role in organ transplant…
2022 American Transplant Congress
Place Based Risk for Early Rejection in Lung Transplant
W. M. Tsuang¹, X. Wang², J. Curtis³
¹Respiratory Institute, Cleveland Clinic, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ³Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH
*Purpose: Within 5 years after lung transplant (LT), half of recipients have lost 20% or more of lung function. Despite a consistent link between social…
2022 American Transplant Congress
OPTN Required SARS-CoV-2 Lower Respiratory Testing for Lung Donors: Early Impact on Patient Safety and Organ Utilization
S. E. Booker¹, C. Martinez¹, C. Fox¹, C. Jett¹, D. Klassen¹, L. Danziger-Isakov², R. M. La Hoz³
¹UNOS, Richmond, VA, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³University of Texas Southwestern Medical Center, Dallas, TX
*Purpose: The OPTN implemented emergency policy on 5/27/21 requiring lower respiratory testing (LRT) by nucleic acid test (NAT) for SARS-CoV-2 (COVID-19) for all potential deceased…
2021 American Transplant Congress
Nanoparticle Mediated Drug Delivery for Lung Transplantation
P. M. Patel¹, S. Jung², C. L. Miller¹, J. M. O¹, T. Costa¹, A. Dehnadi¹, I. Hanekamp¹, X. F. Li², L. Jiang², H. Ichimura², A. Azimzadeh¹, J. C. Madsen³, R. Abdi²
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Medicine, Transplant Research Center, Brigham and Women's Hospital, Boston, MA, ³Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Severe primary graft dysfunction (PGD) affects 30% of lung transplant patients. Pulmonary alveolar macrophages play a significant role in lung PGD, but systemic immunotherapy…
2021 American Transplant Congress
Beneficial Effects of Argon Inhalation on Reducing Lung Ischemia-reperfusion Injury in Miniature Swine
H. Sahara
Div. Organ Replacement and Xeno Tx, Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan
*Purpose: Noble gases, such as xenon and argon (Ar), are chemically inert but have shown to have cytoprotective effect. In contrast to xenon, Ar is…
2021 American Transplant Congress
Aligning Pediatric Waiting List and Post-Transplant Outcomes with the Adult Lung Allocation Score
M. Skeans¹, A. Wey¹, E. Lease², C. Lehr³, J. Alcorn⁴, R. Goff⁴, D. Stewart⁴, M. Valapour³
¹SRTR, Minneapolis, MN, ²Univ of Washington, Seattle, WA, ³Cleveland Clinic, Cleveland, OH, ⁴UNOS, Richmond, VA
*Purpose: Lung allocation is moving toward a continuous distribution framework (CDF), with components for waitlist (WL) urgency and post-transplant (PT) survival, as computed in LAS.…