2016 American Transplant Congress
Achieving Timely Therapeutic Mycophenolic Acid Levels in Pediatric Lung Transplant Patients.
Texas Children's Hospital, Houston, TX.
The purpose of this study was to determine the appropriate initial dose of mycophenolate mofetil (MMF) in pediatric cystic fibrosis (CF) and non-CF lung transplant…2016 American Transplant Congress
Are We Refusing Good Organs? Outcomes of Ventilator Management of Sub-Optimal Lung Donors.
PurposeOptimizing donor lung function is essential for organ acceptance and successful lung transplantation (LTx). We hypothesized that ventilator management of sub-optimal donor lungs, PaO2<300 mmHg,…2016 American Transplant Congress
Outcomes in Lung Transplant Patients Requiring Extracorporeal Membrane Oxygenation (ECMO) in the Perioperative Period.
Cardiovascular Surger, Hospital of the University of Pennsylvania, Philadelphia, PA.
Objective As ECMO therapy is increasingly used to bridge high-risk patients with end-stage respiratory failure to lung transplantation, outcomes of this strategy employed in the…2016 American Transplant Congress
Abrogating Donor-Derived Myd88 Signaling Impairs the Recruitment of Recipient Neutrophils and CD8 T Cells into Lung Allografts in Mice.
Objectives: Transplant ischemia reperfusion injury (IRI) mediated primary graft dysfunction (PGD) remains the predominant cause of short- and long-term graft loss in lung transplantation. This…2016 American Transplant Congress
Hospitalizations, Survival, and Complications: 1-Year Outcomes for Elderly Lung Transplant Recipients.
Houston Methodist Hospital, Houston, TX.
Purpose: In 2014, The International Society for Heart and Lung Transplantation published consensus guidelines listing age greater than 65 years as a relative contraindication to…2016 American Transplant Congress
BATF Deficiency in Tolerant Lung Allograft Recipients Are Resistant to Anti-MHC and Anti-Self-Antigen Mediated Pathogenesis of Obliterative Airway Disease.
Antibodies (Abs) to donor MHC and lung self-antigens (SAgs) administered following induction of lung allograft tolerance by co-stimulation blockade can result in breaking of tolerance…2016 American Transplant Congress
Comparison of Clinical Outcomes in Lung Transplant Patients with and without Preoperative Pulmonary Hypertension.
St. Joseph's Hospital and Medical Center, Phoenix.
Purpose: End-stage lung disease patients (pts) who undergo lung transplantation (LTx) with an elevated mean pulmonary artery pressure (mPAP) are known to have adverse outcomes.…2016 American Transplant Congress
Obliterative Bronchiolitis Following Lung Transplantation Is Preceded by Depletion of Airway Submucosal Glands and Basal Stem Cells.
University of Iowa, Iowa City, IA.
Background: Obliterative bronchiolitis (OB), a major cause of morbidity and mortality following lung transplantation, is characterized by progressive fibrosis of distal airways. We hypothesized that…2016 American Transplant Congress
The Effect of Body Mass Index on Lung Transplant Outcomes.
Background: Lung transplant (LTx) has the potential to effectively extend the life expectancy for patients with end-stage lung disease. Both high and low body mass…2016 American Transplant Congress
Rapamycin Encapsulated Nanoparticles as Pre-Treatment in Lung Transplantation.
Introduction: While short-term lung transplant outcomes have improved over the years, long-term survival rates remain stagnant. Many injuries occur to the donor organ before transplantation,…
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