Articles tagged "Lung transplantation"

2018 American Transplant Congress
Reliability of Bronchiolitis Obliterans Syndrome Reporting to the OPTN
R. Carrico,¹ R. Lehman,¹ K. Uccellini,¹ K. Chan,² T. Whelan.³
¹United Network for Organ Sharing, Richmond; ²Univ of Michigan, Ann Arbor; ³Medical Univ of South Carolina, Charleston.
Background: Chronic rejection of the lung allograft is traditionally classified as bronchiolitis obliterans syndrome (BOS) diagnosed by obstructive airway physiology. The OPTN requires the reporting…
2018 American Transplant Congress
Using a Data Analytics Platform to Improve Patient Care in Pediatric Lung Transplantation
B. Scully,¹ K. Hosek,² D. Dash,² K. Carberry,^1,2 E. Melicoff,³ M. Gazzaneo,³ G. Mallory,³ J. Heinle.¹
¹Surgery, Baylor College of Medicine, Houston, TX; ²Outcomes and Impact Services, Texas Children's Hospital, Houston, TX; ³Pediatric Pulmonology, Baylor College of Medicine, Houston, TX.
PurposeLung transplantation in children remains challenging, requiring extensive infrastructure and expertise. At our institution, we have performed 191 pediatric lung transplants since 2002. We hypothesized…
2018 American Transplant Congress
Immunity and Tolerance after Bilateral Orthotopic Lung Transplant (BOLT) in Tandem with a CD3+/CD19+ Depleted Vertebral Bone Marrow Transplant (BOLT+BMT) from 1 of 8 HLA-Matched Cadaveric Donors
P. Szabolcs,¹ X. Chen,¹ A. Donnenberg,² M. Hill,¹ J. Rowan,¹ S. Mcintyre,¹ G. Kurland,¹ J. Barnum,¹ J. McDyer.¹
¹BMT-CT, Children Hospital of Pittsburgh UPMC, Pittsburgh, PA; ²IDM-HCC, University of Pittsburgh, Pittsburgh, PA.
Primary immunodeficiency patients may develop pulmonary complications and most are ineligible for either lung transplant or BMT due to futility. We report our first 2…
2018 American Transplant Congress
Circulating Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V, and Immunoregulatory Molecules Are Present in Bronchiolitis Obliterans Syndrome Following Pediatric Lung Transplantation
M. Sharma,¹ L. Danziger-Isakov,² P. Heeger,³ S. Sweet,⁴ T. Mohanakumar.¹
¹Norton Thoracic Insitute, St. Joseph's Hosp & Med Ctr, Phoenix; ²Cincinnati Children's Hosp Med Ctr, Cincinnati; ³Icahn Sch Med at Mt Sinai, New York; ⁴Washington Univ Sch Med, St. Louis.
Exosomes containing mismatched donor HLA and lung restricted self-antigens (SAgs), Kα1 Tubulin (Kα1T) and Collagen V (Col-V), have demonstrated in sera and bronchoalveolar lavage fluid…
2018 American Transplant Congress
Incidence of Atrial Arrhythmia after Lung Transplantation with a Universal Prophylaxis Strategy
M. Sullivan,¹ J. Lin,² R. Bag,² L. Potter.¹
¹Department of Pharmacy, The University of Chicago Medicine, Chicago, IL; ²Medicine/Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL.
PurposePostoperative atrial arrhythmias (AA) occur in 19-39% of patients after lung transplantation and are associated with increased mortality, hospital length of stay, and risk of…
2018 American Transplant Congress
Time and Perfusate Dependent Molecular Response in Ex Vivo Lung Perfusion
P. Dromparis,¹ N. Aboelnazar,² S. Wagner,¹ S. Himmat,² C. White,² J. Luc,² D. Freed,² J. Nagendran,² M. Mengel,¹ B. Adam.¹
¹Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; ²Department of Surgery (Cardiac), University of Alberta, Edmonton, Canada.
Lung transplantation has limited organ utilization and high rates of primary graft dysfunction, in part due to acute lung injury (ALI). Cold static preservation (CSP)…
2018 American Transplant Congress
The Aggressive Phenotype: Center-Level Characteristics in the Use of Suboptimal Lungs
M. Kosztowski, E. Bush, X. Luo, A. Thomas, M. Bowring, D. Segev, J. Garonzik Wang.
Johns Hopkins, Baltimore, MD.
The disparity between organ supply and demand has led some centers to expand their criteria for donor selection. We explored utilization of suboptimal lungs to…
2018 American Transplant Congress
Risk Factors for Postoperative Bleeding after Lung Transplantation
D. Adelmann,^1,2 S. Koch,¹ J. Menger,¹ P. Jaksch,³ M. Kurz,¹ M. Mouhieddine,¹ W. Klepetko,³ B. Steinlechner.¹
¹Department of Anesthesia, General Intensive Care and Pain Control, Medical University of Vienna, Vienna, Austria; ²Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA; ³Medical University of Vienna, Vienna, Austria.
Bleeding complications after lung transplantation (LuTX) are associated with increased morbidity. Risk factors for postoperative bleeding complications after LuTX have not yet been reported. In…
2018 American Transplant Congress
Characterization of Exosomal DNA from Human Lung Transplant Recipients
S. Bansal, M. Sharma, R. Walia, R. Bremner, M. Smith, T. Mohanakumar.
Norton Thoracic Institute, St. Joseph's Hosp & Med Ctr, Phoenix.
Exosomes are small vesicles which contains biological molecules including proteins, RNA`s and miRNAs. It has been reported that exosomes may contain ds DNA originated from…
2018 American Transplant Congress
Pattern of Respiratory Virus Infection (RVI) and Chronic Lung Allograft Dysfunction (CLAD) in Lung Transplant Recipients (LTR)
L. Somerville, S. Drews, K. Halloran, N. Lee, D. Kabbani, H. Hirji, K. Doucette, C. Cervera.
University of ALberta, Edmonton, AB, Canada.
Background: The indirect effects of RVI in LTR are controversial. We aimed to define patterns of RVI in LTR and the impact on CLAD and…