ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Lung transplantation"

  • 2022 American Transplant Congress

    Poor Tolerability of CFTR Modulator Therapy in Lung Transplant Recipients

    C. Doligalski, C. McKinzie, A. Yang, R. Coakley

    UNC Health, Chapel Hill, NC

    *Purpose: Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is a highly effective therapy for cystic fibrosis (CF) with potential benefits in lung transplant recipients (LTRs) for extrapulmonary CF manifestations, however…
  • 2022 American Transplant Congress

    Missed Opportunities in Lung Transplant

    C. J. Lehr, P. R. Gunsalus, M. Valapour, J. E. Dalton

    The Cleveland Clinic, Cleveland, OH

    *Purpose: Recent changes in lung allocation policy seek to improve geographic disparities in access. This study aims to understand geographic variation in donor availability and…
  • 2022 American Transplant Congress

    dd-cfDNA Varies Among Diagnostics Groups of Pulmonary AMR

    D. Levine1, C. Giner1, C. Pham2, R. Woodward3, A. Roux4

    1University of Texas Health System San Antonio, San Antonio, TX, 2CareDX, South San Francisco, CA, 3CareDx, South San Francisco, CA, 4Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France

    *Purpose: Antibody mediated rejection (AMR) in lung transplant remains complex, with differential diagnosis often overlapping with other causes of lung dysfunction. Diagnostic certainty declines to…
  • 2022 American Transplant Congress

    Strada Deficiency Results in Inhibition of Tumor Suppressor Gene Liver Kinase B1 Resulting in Epithelial Mesenchymal Transition Leading to Chronic Murine Lung Allograft Rejection

    M. Rahman, S. Bansal, R. Ravichandran, A. Sureshbabu, W. Lie, S. Perincheri, M. Smith, R. Bremner, T. Mohanakumar

    St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: Recently we demonstrated that tumor suppressor gene Liver Kinase B1 (LKB1) is down regulated in lung biopsies and in the circulating exosomes of lung…
  • 2022 American Transplant Congress

    Donor-Derived IL-33 Plays a Critical Role in Lung Allograft Acceptance

    Y. Guo1, Z. Mei1, M. Khalil1, D. Li1, A. Banerjee1, A. Gelman2, D. Kreisel2, A. Krupnick1

    1Department of Surgery, University of Maryland, Baltimore, Baltimore, MD, 2Washington University School of Medicine in St Louis, Saint Louis, MO

    *Purpose: IL-33 is considered an alarmin secreted in response to tissue damage. While it is elaborated by the lung allograft as part of ischemia-reperfusion injury…
  • 2022 American Transplant Congress

    Lung Transplant Waitlist Outcomes for Blood Group O Candidates After the Expansion of the Primary Allocation Unit in November 2017

    S. Greissman1, M. Anderson2, S. Arcasoy3, A. Dimango3, M. Gabriela3, H. Grewal3, H. Robbins3, L. Shah3, J. Costa3, F. D'Ovidio3, M. Leiva Juarez3, P. Lemaitre3, J. Sonett3, L. Benvenuto3

    1Department of Internal Medicine, New York Presbyterian, New York, NY, 2University of Pennsylvania, Philadelphia, PA, 3Columbia University, New York, NY

    *Purpose: Blood group O is associated with decreased lung transplant rates. Occasionally, blood group donor O lungs are allocated to non-blood group O recipients. Since…
  • 2022 American Transplant Congress

    Immunomodulation in Lung Transplant May Facilitate Transformation of Usual Interstitial Pneumonia Into Pleuroparenchymal Fibroelastosis

    Q. Cai1, K. Batra2, J. R. Torrealba1

    1Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, 2Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, TX

    *Purpose: Pleuroparenchymal fibroelastosis (PPFE) is a rare but distinctive manifestation of interstitial lung disease (ILD) characterized by a highly elastotic pattern of lung fibrosis. Its…
  • 2022 American Transplant Congress

    B and Plasma Cell Populations Drive Chronic Rejection After Lung Transplantation

    M. Bueno1, N. F. Smirnova2, K. Riemondy3, P. Suresh1, M. Brown1, X. Wang1, S. Collins4, J. Sembrat1, M. Koenigshoff1, M. Snyder1, J. McDyer1, O. Eickelberg1

    1Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 2I2MC, INSERM UMR1297, Toulouse, France, 3Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, 4Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO

    *Purpose: Chronic lung allograft dysfunction (CLAD) remains the major determinant of morbidity and mortality post-lung transplantation (LTx). Bronchiolitis obliterans syndrome (BOS) is the most prevalent…
  • 2022 American Transplant Congress

    Impact Of Antifungal Prophylaxis Discontinuation On Immunosuppression In Lung Transplant Recipients

    R. Huntsman, K. Neuhaus

    Pharmacy, Cleveland Clinic, Cleveland, OH

    *Purpose: The purpose of this study is to characterize the impact of antifungal discontinuation on immunosuppressant levels and incidence of acute rejection and fungal infections…
  • 2022 American Transplant Congress

    Differing Gene Expression Profiles and Signaling Pathways Observed Between Alloreactive and Tolerant T Cells in a Recipient Following Bilateral Orthotopic Lung Transplant (BOLT) and Bone Marrow Transplant (BMT) from the Same Cadaveric UNOS Donor

    P. Szabolcs, E. Garchar, D. Rajasundaram, X. Chen

    UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA

    *Purpose: Primary immunodeficiency (PID) patients may develop pulmonary complications, and most are ineligible for either BOLT or BMT due to futility. A prospective trial in…
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