Articles tagged "Lung transplantation"

2022 American Transplant Congress
High TTV Load Before First Vaccine Dose is Associated with Poor Serological Response to Covid-19 Vaccination in Lung Transplant Recipients
C. C. Van Leer Buter¹, R. A. Hoek², E. A. Verschuuren³, R. D. de Vries⁴, D. van Baarle¹, M. van der Heiden¹, H. G. Niesters¹, C. GeurtsvanKessel⁴
¹Dept. of Medical Microbiology, University Medical Center Groningen, Groningen, Netherlands, ²Dept. of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, Netherlands, ³Dept. of Pulmonary Diseases,, University Medical Center Groningen, Groningen, Netherlands, ⁴Dept. of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: Torque tenovirus (TTV), a highly prevalent virus which is not known to cause pathology in humans, is currently being investigated as a marker of…
2022 American Transplant Congress
Benefit of Kidney Transplantation for Post Lung Transplantation Renal Failure: Need for Priority Allocation
S. Karhadkar¹, A. Gregor¹, K. Jonathan¹, J. Dawes¹, A. Diamond², K. Wirshup¹, A. DiCarlo¹
¹Temple University Hospital, Philadelphia, PA, ²-, Garnet Valley, PA
*Purpose: Nephrotoxicity is a major side effect of thoracic transplantation. Many patients will eventually require renal transplantation (KAL) to manage their developing ESRD. Recently, simultaneous…
2022 American Transplant Congress
Place Based Risk for Early Rejection in Lung Transplant
W. M. Tsuang¹, X. Wang², J. Curtis³
¹Respiratory Institute, Cleveland Clinic, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ³Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH
*Purpose: Within 5 years after lung transplant (LT), half of recipients have lost 20% or more of lung function. Despite a consistent link between social…
2022 American Transplant Congress
Assessment of Letermovir as Universal Prophylaxis for Cytomegalovirus Infection in Lung Transplant Recipients
L. F. Borges, T. Sparkman, K. Gutierrez, J. Banbury
UAB Hospital, Birmingham, AL
*Purpose: Cytomegalovirus (CMV) poses a significant concern in the post-operative management of lung transplant (LT) recipients. Current recommended prophylactic strategies with ganciclovir (GCV) or valganciclovir…
2022 American Transplant Congress
Temporal Trends in Utilization, Discard, and Outcomes for Extended Criteria Donor Lungs
A. Hallett¹, L. Zeiser¹, W. Lightle², J. Ruck¹, J. Alejo¹, A. Massie¹, D. Segev¹
¹Johns Hopkins, Baltimore, MD, ²Baylor, Houston, TX
*Purpose: Extended criteria donor lungs (ECDL) are defined as those failing to meet ≥1 standard donor criteria (P/F > 300, age < 55, smoking <…
2022 American Transplant Congress
Effect of Micafungin Bridging on Prevention of Invasive Candidiasis Post Lung Transplantation
C. Baladad¹, M. Converse¹, K. DeSear¹, S. Karimi¹, E. Rubido¹, G. El Helou², T. Pasley¹
¹Pharmacy, University of Florida Health, Shands, Gainesville, FL, ²Infectious Diseases, University of Florida Health, Shands, Gainesville, FL
*Purpose: This study aims to determine the effect of micafungin, added as a bridging agent to azole antifungal prophylaxis, in lung transplantation patients with positive…
2022 American Transplant Congress
Natural Killer Cell NKG2D Receptor Mediates Airway Cell Hypoxic Injury Through Recognition of Stress Molecules
T. Tsao¹, E. Aminian¹, A. Shemesh¹, L. Tran¹, P. Wang¹, F. Deiter¹, J. R. Greenland², D. R. Calabrese¹
¹University of California, San Francisco, San Francisco, CA, ²Medicine, University of California, San Francisco, CA
*Purpose: Primary graft dysfunction (PGD), the clinical syndrome of pulmonary hypoxia and reperfusion, occurs afer 1/3 of all lung transplants, and accounts for excess mortality.…
2022 American Transplant Congress
Lung Allograft-Resident Eosinophils Maintain Long-Term Graft Integrity by Restraining Humoral Alloimmunity
Z. Mei¹, Y. Guo¹, D. Li¹, M. Khalil¹, A. Banerjee¹, A. Gelman², D. Kreisel², A. Krupnick³
¹Department of Surgery, University of Maryland, Baltimore, Baltimore, MD, ²Washington University in St. Louis, St. Louis, MO, ³Department of Surgery, University of Maryland, Baltimore, baltimore, MD
*Purpose: The finding that eosinophils facilitate immunosuppression-mediated acceptance of murine lung allograft by downregulating alloreactive CD8+ T cells has been recently described by our group.…
2022 American Transplant Congress
Oseltamivir for the Prevention of Influenza Infection in Lung Transplant Recipients at an Academic Medical Center
D. Majmundar, A. Mishkin, J. Burnell, C. Ruggia-Check, J. Au
Temple University Hospital, Philadelphia, PA
*Purpose: Influenza is commonly considered a community acquired infection, but in transplant recipients, nosocomial transmission is frequently encountered. The lung transplant program at Temple University…
2022 American Transplant Congress
The Unique Course of dd-cfDNA After Lung Transplant
D. Levine¹, C. Giner¹, C. Pham², R. Woodward³, A. Roux⁴
¹University of Texas Health System San Antonio, San Antonio, TX, ²CareDX, South San Francisco, CA, ³CareDx, South San Francisco, CA, ⁴Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France
*Purpose: The time necessary for dd-cfDNA to reach baseline levels following transplantation has been reported in kidney, heart, and liver as 14-21 days. We explored…