Articles tagged "Lung transplantation"

2019 American Transplant Congress
Polymorphisms in Mycophenolate Mofetil Glucuronidation Gene Are Associated with Leukopenia and Decreased CLAD-Free Survival
A. Barnes, D. R. Calabrese, E. Henricksen, R. Florez, K. Dewey, P. Wang, J. Teraoka, K. Lien, S. Hays, J. P. Singer, J. Golden, J. Kukreja, J. R. Greenland
UCSF Medical Center, San Francisco, CA
*Purpose: Lung transplant recipients vary in their tolerance of the immunosuppressant mycophenolate mofetil (MMF). Single nucleotide polymorphisms (SNPs) in UDP-glucuronosyltransferase 2B7 (UGT2B7) increase conversion of…
2019 American Transplant Congress
Alteration in Local Complement Activation in First 24h Post-Lung Transplantation (LTx) Helps Identify Recipients Developing Primary Graft Dysfunction
H. Kulkarni¹, M. Elvington², L. Ma¹, M. Cano¹, K. Pugh³, R. Hachem¹, J. Atkinson², A. Gelman³
¹Pulmonary and Critical Care Medicine, Washington University, Saint Louis, MO, ²Rheumatology, Washington University, Saint Louis, MO, ³Surgery, Washington University, Saint Louis, MO
*Purpose: Primary graft dysfunction (PGD) is a form of acute lung injury driven by ischemia-reperfusion mediated damage. An increase in plasma complement proteins - specifically…
2019 American Transplant Congress
Comparison of Basiliximab and Alemtuzumab for Lung Transplant Induction
S. Mietz¹, D. Roe², E. Lushin¹, E. Anderson¹, C. Hage²
¹Pharmacy, Indiana University Health, Indianapolis, IN, ²Pulmonary Critical Care, Indiana University Health, Indianapolis, IN
*Purpose: Compare alemtuzumab and basiliximab used for lung transplant in terms of rejection, CLAD, and mortality.*Methods: A retrospective review of lung transplants performed between 2010…
2019 American Transplant Congress
Opioid and Benzodiazepine Use in Lung Transplant Candidates: A National Survey of Policies and Practices
H. Bruschwein¹, V. Andersen¹, H. Patel², J. Fleming³, A. Shahane¹, M. Weder¹
¹University of Virginia, Charlottesville, VA, ²University of North Carolina, Chapel Hill, NC, ³Medical University of South Carolina, Charleston, SC
*Purpose: The opioid epidemic has raised the question of how transplant teams should work with patients who are prescribed opioids. Benzodiazepine use has also received…
2019 American Transplant Congress
Improving Access to Lung Transplant through Donor Strategy: A Decision Analysis
W. Tsuang, B. Udeh
Cleveland Clinic, Cleveland, OH
*Purpose: The use of Donation after Cardiac Death (DCD) donors in addition to Donation after Brain Death (DBD) donors may increase patient access to lung…
2019 American Transplant Congress
Impact Of Aggressive Utilization Of Liver Allografts On Outcomes
A. Rana, M. Kueht, N. Galvan, R. Cotton, C. O'Mahony, J. Goss
Baylor College of Medicine, Houston, TX
*Purpose: Many risk factors impact outcomes for liver transplantation, among them are factors that are particular to individual transplant centers or center-level factors. Our aim…
2019 American Transplant Congress
Frailty is Highly Prevalent in Lung Transplant Candidates and Varies by Frailty Tool
A. O'Boye, K. Leitner, M. Kelly, J. Wright, J. Lee, M. Sala, R. Tomic, S. Bhorade
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Lung transplantation is a lifesaving therapy in patients with advanced lung disease. However, frail lung transplant candidates are more likely to be delisted or…
2019 American Transplant Congress
The Burden of Recipient Driving Distance and Post Lung Transplant Outcomes: A National Cohort Study
W. Tsuang, S. Arrigain, R. Lopez, M. Snair, K. McCurry, M. Budev, J. Schold
Cleveland Clinic, Cleveland, OH
*Purpose: There are only 75 lung transplant centers in the United States, which leads to a spectrum of travel burdens among patients in order to…
2019 American Transplant Congress
Assessment of the Global Practice of Pediatric Living Donor Liver Transplantation: Comparison of U.S. and International Programs
J. Emamaullee¹, M. Kim¹, C. Conrad¹, C. Lane¹, P. Singh¹, C. Niemann², L. Sher¹, Y. Genyk¹
¹University of Southern California, Los Angeles, CA, ²University of California-San Francisco, San Francisco, CA
*Purpose: As programs have become more experienced with living donor liver transplantation (LDLT), technical hurdles have been overcome and superior graft and patient survival has…
2019 American Transplant Congress
Correlation between Gene Expression and Histology in Transbronchial Lung Transplant Biopsies
B. Adam, K. Du, S. Rotich, M. Mengel
University of Alberta, Edmonton, AB, Canada
*Purpose: Transbronchial lung transplant biopsies (TBBx) are limited by non-specific histologic lesions and suboptimal interobserver reproducibility. Gene expression offers a potentially more precise, objective and…