2019 American Transplant Congress
The Molecular Features of Chronic Lung Allograft Dysfunction (CLAD) in Transbronchial and Endobronchial Mucosa Biopsies
1University of Alberta, Edmonton, AB, Canada, 2ATAGC, University of Alberta, Edmonton, AB, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD), the major long-term problem in lung transplantation, requires new strategies for prevention and management. However, CLAD is infrequently diagnosed…2019 American Transplant Congress
Caregiving in Thoracic Transplantation–A SR/MA
*Purpose: Caregivers are required for heart and lung transplantation, however, little emphasis is placed on the pre-transplant caregiving experience. Our objective was to perform a…2019 American Transplant Congress
Bronchoalveolar Lavage Biomarkers Predict Lung Transplant Survival
*Purpose: In lung transplants (LTx), chronic rejection remains a major cause of morbidity and mortality following transplantation, mainly from chronic lung allograft dysfunction (CLAD). Two…2019 American Transplant Congress
Syphilis Transmission in Solid Organ Transplantation
Emory University Hospital, Atlanta, GA
*Purpose: Syphilis is a sexually transmitted infection that affects people worldwide. While transmission generally occurs via sexual contact, other modes of transmission are possible, including…2019 American Transplant Congress
Azole Use and Fungal Pathogens in Cystic Fibrosis versus Non-Cystic Fibrosis Lung Transplant Recipients
*Purpose: Cystic fibrosis (CF) patients exhibit unique pharmacokinetic principles. Azole antifungals show marked inter- and intra-patient variability. We aimed to improve itraconazole (ITR) use and…2019 American Transplant Congress
Not All Donor-Specific Antibodies Are Equal: Predictors of Risk of Chronic Lung Allograft Dysfunction
*Purpose: Donor-specific HLA antibodies (DSA) have been previously associated with chronic lung allograft dysfunction (CLAD). However, the DSA characteristics that predict risk of CLAD are…2019 American Transplant Congress
Impact of Multidrug-Resistant Microbes of Donor Lower Respiratory Tract on Early Posttransplant Pneumonia in Bilateral Lung Transplant Recipients without Pretransplant Infection
*Purpose: Colonized microbes in lower respiratory tract (LRT) of deceased donor allograft can potentially cause early posttransplant pneumonia (EPTP) that leads to detrimental outcome in…2019 American Transplant Congress
Effect of Enoxaparin Prophylaxis on Early VTE Post Lung Transplant
*Purpose: Thromboembolic complications are common post-transplant leading to significant morbidity. We instituted early enoxaparin prophylaxis (ppx) in lung transplant recipients (LTR) due to an observed…2019 American Transplant Congress
Decline in Club Cell Secretory Protein Results in Immune Responses to Lung Self-Antigens (Kα1 Tubulin and Collagen V) and Development of Chronic Rejection Following Human Lung Transplantation
*Purpose: Club cell secretory protein (CCSP) levels have been employed as a biomarker for respiratory stress in athletes, asthma patients, and in experimental acute and…2019 American Transplant Congress
Target Itraconazole Trough Concentration for Prophylaxis in Lung Transplant
*Purpose: Itraconazole (ITR) therapeutic drug monitoring (TDM) for prophylaxis in lung transplant recipients (LTR) is not well characterized. Our purpose was to evaluate ITR trough…
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