Articles tagged "Liver"

2022 American Transplant Congress
18 Month Review of Liver Acuity Circles Allocation
J. Foutz¹, S. Noreen¹, M. Cafarella¹, A. Wilk¹, J. Trotter², S. Biggins³, J. Pomposelli⁴
¹United Network for Organ Sharing, Richmond, VA, ²Baylor University Medical Center, Dallas, TX, ³University of Washington, Seattle, WA, ⁴University of Colorado, Aurora, CO
*Purpose: Acuity circles (AC) allocation was implemented on 2/4/2020 with a goal of removing DSA and region from liver allocation and broadening the distribution of…
2022 American Transplant Congress
Controlling Instability at Reperfusion: Another Benefit of Normothermic Machine Perfusion Using OCS Liver
C. S. Hwang¹, C. Shi², M. Patel¹, J. Shah¹, L. DeGregorio¹, S. Hanish¹, Y. Kadakia³, U. Chaudhary³, E. Okoro², S. Cheruku², P. Lahsaei², P. Vagefi¹, M. MacConmara⁴
¹Surgery, University of Texas Southwestern Medical Center, Dallas, TX, ²Anesthesia, University of Texas Southwestern Medical Center, Dallas, TX, ³University of Texas Southwestern Medical Center, Dallas, TX, ⁴TransMedics, Andover, MA
*Purpose: Organ Care System (OCS) Liver is a portable ex-vivo normothermic liver perfusion device recently shown to provide superior donor organ preservation. The impact of…
2021 American Transplant Congress
Change in Deceased Donor Demographics with Drug Intoxication Deaths: 2010 – 2019
D. Musgrove, D. Zaun, A. Israni, J. Snyder
SRTR, Minneapolis, MN
*Purpose: To understand the demographic change in deceased donor causes of death associated with drug intoxication, we explored trends over the 10-year period ending in…
2021 American Transplant Congress
An Immune-modulatory Strategy to Mitigate Hepatic Ischemia/reperfusion Injury in a Murine Model
A. Kobayashi, A. Wanchoo, S. Farhadi, J. Simonovich, S. Duarte, V. Boominathan, S. Shrestha, G. Hudalla, B. G. Keselowsky, A. Zarrinpar
University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is the leading cause of early graft dysfunction and contributes to the shortage of donor liver grafts. However, despite its…
2021 American Transplant Congress
Liver Transplantation Following Checkpoint Inhibitor Therapy – Timing is Everything
G. T. Schnickel¹, J. Parekh¹, Y. Kono², J. Berumen¹, V. Ajmeera², K. Mekeel¹
¹Division of Transplant and Hepatobiliary Surgery, Department of Surgery, University of California San Diego, San Diego, CA, ²Division of Gastroenterology, Department of Medicine, University of California San Diego, San Diego, CA
*Purpose: Use of checkpoint inhibitors (CPI) prior to liver transplantation has not been well studied and limited case reports describe a risk of early graft…
2021 American Transplant Congress
Dual Lactate Clearance in the Liver Viability Assessment During Normothermic Machine Perfusion
M. Xu¹, F. Zhou¹, O. Ahmed¹, J. Shin¹, Y. Zhu¹, G. Upadhya¹, K. Byrnes², B. Wong¹, J. Kim¹, Y. Lin¹, W. Chapman¹
¹Department of Surgery, Washington University, St. Louis, MO, ²Department of Pathology and Immunology, Washington University, St. Louis, MO
*Purpose: Liver normothermic machine perfusion (NMP) has been increasingly performed as a tool of organ preservation and to evaluate donor function. The perfusate lactate clearance…
2021 American Transplant Congress
Superior Post-transplant Clinical Outcomes Using Portable Normothermic Perfusion and Assessment with the Organ Care System (ocs) Liver System: 1-year Outcomes of the Ocs Liver Protect Randomized Controlled Trial
J. Markmann¹, M. Abouljoud², M. Ghobrial³, C. Bhati⁴, S. Pelletier⁵, J. Magliocca⁶, T. Pruett⁷, A. Lu⁸, M. Rizzari⁹, S. Ottmann¹⁰, T. Klair¹¹, C. Eymard¹², G. Roll¹³, G. Reyes¹⁴, S. Black¹⁵, S. Florman¹⁶, S. Mirani¹⁷, C. Marsh¹⁸, G. Schnickel¹⁹, M. Kinkhabwala²⁰, A. Demetris²¹, H. Yeh²², P. Vagefi²³, M. MacConmara²³
¹MGH, Boston, MA, ²Henry Ford, Detroit, MI, ³Houston Methodist, Houston, TX, ⁴Virginia Commonwealth, Richmond, VA, ⁵UVA, Charlottesville, VA, ⁶Emory, Atlanta, GA, ⁷U. Minnesota, Minneapolis, MN, ⁸Tampa General, Tampa, FL, ⁹Henry Ford, Detriot, MI, ¹⁰Johns Hopkins, Baltimore, MD, ¹¹University of Texas HSC, San Antonio, TX, ¹²University of Tennessee HSC, Memphis, TN, ¹³UCSF, San Francisco, CA, ¹⁴U. Washington, Seattle, WA, ¹⁵Ohio State, Columbus, OH, ¹⁶Mt. Sinai, New York, NY, ¹⁷U. Nebraska, Omaha, NE, ¹⁸Scripps Clinic, San Diego, CA, ¹⁹U. San Diego, San Diego, CA, ²⁰Montefiore, New York, MA, ²¹UPMC, Pittsburgh, PA, ²²Massachusetts General Hospital, Boston, MA, ²³UT Southwestern, Dallas, TX
*Purpose: The OCS Liver PROTECT Trial was the first U.S. randomized controlled trial for liver perfusion and was designed to evaluate the impact of portable…
2021 American Transplant Congress
Nanodiamond-doxorubicin Complexes Improve Hepatic Ischemia/reperfusion Injury
A. Kobayashi, C. Grady, S. Duarte, V. Boominathan, S. Shrestha, A. Zarrinpar
Surgery, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major inflammatory event in liver transplantation that is mediated by oxidative stress. Doxorubicin (DOX) can mitigate oxidative stress…
2021 American Transplant Congress
Machine Learning Informs Utility-Based Non-Directed Living Liver Donor Allocation
K. Bambha¹, J. Perkins¹, M. Sturdevant¹, S. W. Biggins¹, R. Bakthavatsalam¹, P. Healey², A. Dick², J. Reyes¹
¹University of Washington, Seattle, WA, ²Seattle Children's, Seattle, WA
*Purpose: To maximize non-directed living liver donor graft utility, we developed analytic models predicting 10-year graft survival post liver transplant (LT).*Methods: We analyzed OPTN living…
2021 American Transplant Congress
Are Liver Transplant Center Websites Accessible to All?
C. E. Jacobson¹, R. Olmeda Barrientos², M. A. Anderson³, M. J. Englesbe³, S. A. Waits³, V. S. Valbuena³
¹University of Michigan Medical School, Ann Arbor, MI, ²University Of California – Riverside, School of Medicine, Riverside, CA, ³Department of Surgery, University of Michigan Health System, Ann Arbor, MI
*Purpose: Ensuring equitable access to transplant center information is an important step in combating health disparities in liver transplantation. This study aimed to assess liver…

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