2020 American Transplant Congress
Biomarkers AFP in Combination with AFP-l3 and DCP Predicts Tumor Progression in Treatment Native HCC Patients
Ochsner Health System, New Orleans, LA
*Purpose: Hepatocellular carcinoma (HCC) treatment with locoregional therapy (LRT) is standard treatment to downstage within Milan Criteria. In this study, we retrospectively analyzed early-stage HCC…2020 American Transplant Congress
Opioid Use Prior to Liver Transplant is Associated with Increased Risk of Death after Transplant
University of California, San Francisco, San Francisco, CA
*Purpose: The impact of the opioid epidemic on liver transplant (LT) candidates and recipients has not been widely studied, but pre-LT opioid use in LT…2020 American Transplant Congress
Antibiotic Pretreatment Alleviates Liver Transplant Damage by Modulating the Composition of Commensal Microbiota
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: The human intestinal microbiome contains more than 100 trillion commensal microorganisms, exceeding the number of cells in the human body by 10-fold. Although recent…2020 American Transplant Congress
TGR5/Cathepsin E Signaling Regulates Macrophage Innate Immune Activation in the Sterile Inflammatory Liver Injury
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: The hepatic proinflammatory response represents a major cause of liver ischemia and reperfusion (IR) injury. Although the role of plasma membrane-bound G protein-coupled bile…2020 American Transplant Congress
Nanodiamond-Doxorubicin Complexes Improve Hepatic Ischemia/Reperfusion Injury
Surgery, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major inflammatory event in liver transplantation that is mediated by oxidative stress. Doxorubicin (DOX) can mitigate oxidative stress…2020 American Transplant Congress
Everolimus-Treatment Inhibits the Transition of the Immature Subsets of Liver Natural Killer Cells to Mature State and Enhances Anti-Tumor Activity
Gastreenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: The immunosuppressive regimen currently used after organ transplantation efficiently reduces the adaptive immune components. During suppressed adaptive immunity, the innate immune cells may play…2020 American Transplant Congress
The Perioperative Coagulation Profile of Hepatocellular Carcinoma During Liver Transplantation Compared to Patients with Non-Malignant Disease: A Cause or Association for Decreased Blood Product Utilization During Liver Transplantation?
University of Colorado, Aurora, CO
*Purpose: Hepatobiliary malignancies have been associated with hyper-coagulability. However, the impact of hepatocellular carcinoma (HCC) on coagulation during liver transplantation remains less clear. We hypothesize…2020 American Transplant Congress
The Liver Outcome Monitoring Registry Donor Risk Index: A New Measure of Deceased Donor Liver Quality
*Purpose: The liver donor risk index (LDRI) created in 2006 evaluated the relative risk of graft failure, however its weaknesses have limited its use in…2020 American Transplant Congress
Real-Time Viability Assessment During Normothermic Machine Perfusion with Resonance Raman Spectroscopy
*Purpose: Viability assessment during normothermic machine perfusion (NMP) continues to lack objective metrics that facilitate accurate clinical decision making, in order to minimize discard rates…2020 American Transplant Congress
The Protective Effect of Hypothermic Oxygenated Machine Perfusion (HOPE) Onresuscitating Steatotic Liver and its Underlying Mechanism
*Purpose: To analyze the impact of steatotic livers with conventional cold storage (CS) and hypothermic oxygenated perfusion (HOPE) approaches, and further to investigate the rescue…
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