Articles tagged "Liver"

2019 American Transplant Congress
Sirna Uptake During Ex Vivo Hypothermic And Normothermic Liver Machine Perfusion: Beginning Of A New Era Of Organ Preservation
A. Gillooly¹, C. Moore¹, J. Perry¹, I. Bruggenwirth², M. Thijssen², X. Wang¹, X. E¹, P. Mandrekar¹, T. Kowalik¹, R. Porte², H. Leuvenink², R. Abdi³, A. Bozorgzadeh¹, P. N. Martins¹
¹University of Massachusetts Medical School, Worcester, MA, ²University of Groningen, Groningen, Netherlands, ³Brigham and Women's Hospital, Boston, MA
*Purpose: RNA interference (RNAi) is a natural gene modulation process that was recently approved for clinical use and has great potential for treatment of many…
2019 American Transplant Congress
Differentiation and Characterization of Human Endodermal Precursors for Liver Cell Therapies
W. S. Fagg¹, N. Liu¹, M. Shoja¹, I. Patrikeev², M. Motamedi², J. Fair¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Opthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX
*Purpose: Mouse pluripotent stem cell (PSC)-derived endoderm precursors (EPs) have small size, endoderm lineage gene expression signatures, and high proliferation rates, that allow engraftment in…
2019 American Transplant Congress
Outcomes Following Open Inguinal Hernia Repair in Liver Transplant versus Cirrhotic Patients
N. Siegel, A. Kernodle, S. DiBrito, T. Ishaque, D. Segev, J. Garonzik-Wang
Johns Hopkins, Baltimore, MD
*Purpose: Patients with cirrhosis are at an increased risk for post-operative complications after open inguinal hernia repair (OIHR). Conversely, liver transplant recipients (LTR) may have…
2019 American Transplant Congress
Performance Improvement Initiative: Ambulatory Tool to Improve Tacrolimus Intrapatient Variability (IPV) Monitoring in Kidney & Liver Transplant Recipients
T. E. Kaiser¹, N. S. Ejaz¹, S. Tremblay¹, N. J. Parrish², S. Schinasi², J. Harris², A. Govil¹, N. Anwar¹, R. R. Alloway¹
¹University of Cincinnati, Cincinnati, OH, ²UC Health, Cincinnati, OH
*Purpose: High tacrolimus (TAC) intrapatient variability (IPV) is associated with poorer outcomes. Manual monitoring of TAC IPV is labor intensive and not always feasible. As…
2019 American Transplant Congress
Immunosuppressant Adherence in Adult Liver Transplant Recipients in the United States
W. S. Cherikh¹, A. R. Wilk¹, J. Maghirang¹, E. A. Witt², H. Kirkham², S. Boghani², N. Hira³, G. Pietradoni², D. K. Klassen¹
¹United Network for Organ Sharing, Richmond, VA, ²Walgreen Co, Deerfield, IL, ³AllianceRx Walgreens Prime, Orlando, FL
*Purpose: We sought to determine the characteristics associated with immunosuppressant (IS) medication adherence among adult recipients of deceased donor liver transplants (TXs) in the US.*Methods:…
2019 American Transplant Congress
Multi-Omics Approach to Accurately Assess Early Graft Injury in Liver Transplantation
D. Maluf¹, V. Sai Bontha¹, A. Bajwa¹, R. Helmick¹, P. J. Horton¹, C. Eymard¹, J. Eason², V. Mas³
¹UTHSC, Memphis, TN, ²UTHSC. Director of Transplant Institute, Memphis, TN, ³UTHSC Director Transplant Research Institute, Memphis, TN
*Purpose: We investigated global DNA methylation (DNAm) patterns during ischemia reperfusion (I/R) injury in liver transplant (LT) patients, and their role on regulating gene expression…
2019 American Transplant Congress
Loss of FXR Exacerbates Liver Damage by Activating NLRP3 Inflammasome Induced Pyroptosis in Liver Ischemia Reperfusion Injury
Z. Zhu, Y. Zhang, Y. Tang, S. Huang, Q. Zhao, W. Ju, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: The relationships among Farnesoid X receptor (FXR), nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome and pyroptosis are largely unknown in…
2019 American Transplant Congress
Etiology of Liver Disease Affects Weight Gain after Liver Transplant
A. Chandrakumaran¹, M. B. Siddiqui², S. Patel², F. Lin³, J. Laurenzano², J. Clinton², T. Reichman⁴, C. Bhati⁴, M. S. Siddiqui²
¹Internal Medicine, Virginia Commonwealth University, Richmond, VA, ²Gastroenterology & Hepatology, Virginia Commonwealth University, Richmond, VA, ³Virginia Commonwealth University, Richmond, VA, ⁴Transplant Surgery, Virginia Commonwealth University, Richmond, VA
*Purpose: Weight gain after liver transplant (LT) is a key driver of cardiometabolic disease and associated mortality. There is little known about trends in post-LT…
2019 American Transplant Congress
Mortality around the One-Year Survival Metric after Liver Transplantation in the United States
C. Blebea¹, P. Chatterjee², A. Nathan¹, J. Diamond¹, H. J. Goldberg², A. Courtwright¹
¹Hospital of the University of Pennsylvania, Philadelphia, PA, ²Brigham and Women’s Hospital, Boston, MA
*Purpose: Liver transplant programs in the United States are evaluated on one-year survival, among other factors. This may create an unintended incentive to continue life-sustaining…
2019 American Transplant Congress
Pilot Testing Of A Novel Transition Program
J. Uze, N. Yazigi
Transplantation, MedStar Georgetown University Hospital, Washigton, DC
*Purpose: Pediatric patients coming of age face many compliance hurdles, the roots of most lying in poor coping with heir state as a transplant recipient,…