2018 American Transplant Congress
PGE2/Beta-Catenin/XBP1 Signaling Controls Mesenchymal Stem Cell-Mediated Immune Regulation in Liver Ischemia and Reperfusion Injury
The Dumont-UCLA Transplant Center, Department of Surgery, Los Angeles, CA.
Background: Mesenchymal stem cells (MSCs) display profound immunomodulatory properties and tissue repairing capability under inflammatory conditions. However, it is unknown how MSCs may affect immunity…2018 American Transplant Congress
Is Percent Exception at Transplant a Driver of MELD Inflation?
1SRTR, Minneapolis, MN; 2Stanford University, Stanford, CA; 3Univ of Minnesota, Minneapolis, MN.
Before 2016, the proportion of deceased donor liver recipients with an exception status at liver transplant (LT) correlated strongly with median MELD at transplant (MMaT)…2018 American Transplant Congress
Factors Associated with Listing for Liver Transplantation in an OPO Other Than the Resident OPO
Geographic disparity in access to liver transplantation has been well described. Candidates may travel to be listed in OPOs with better access. We hypothesized that…2018 American Transplant Congress
Curative Correction of FAH Deficiency by Chimeric Stem Cells Transplantation
Fumarylacetoacetate hydrolase (FAH) deficient pigs have been proposed as surrogate hosts for large scale in vivo expansion of normal FAH+ hepatocytes. However, immunologic rejection prevents…2018 American Transplant Congress
Impact of On-Site Overestimation of Macrosteatosis on Donor Liver Biopsy
Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans.
Introduction: Estimation of hepatic steatosis is an important variable in determining suitability of a donor liver allograft for transplantation. Differentiation between and quantification of macro-…2018 American Transplant Congress
Comprehensive Validation of Different Clinical Prediction Models on Short- and Long-Term Outcome Following Orthotopic Liver Transplantation
Background: Organ shortage remains a major problem in orthotopic liver transplantation (OLT). An optimal utilization of the donor pool with better prediction of outcome is…2018 American Transplant Congress
Living Donor Liver Transplantation for Alcoholic Liver Disease: Data from the A2ALL Study
Surgery, University of California, San Francisco, San Francisco, CA.
The literature on living donor liver transplantation (LDLT) for alcoholic liver disease (ALD) is primarily from single Asian centers. We investigated LDLT outcomes for ALD…2018 American Transplant Congress
DSA-Level Liver Availability and Liver Utilization
DSA-level geographic disparity in access to deceased-donor liver transplantation is well described. However, understanding the relationship between liver availability in a DSA and exportation of…2018 American Transplant Congress
Poverty, End Stage Liver Disease, and Transplantation in Georgia
1Surgery, Emory University, Atlanta, GA; 2Medicine, University of Pennsylvania, Philadelphia, GA.
Background: Though discussions of equity in liver transplantation remain focused primarily on relative availability of allografts as a measure of access, differences in disease burden…2018 American Transplant Congress
Hyperglycemia Aggravates Hepatic Ischemia and Reperfusion Injury by Inhibiting Liver Resident Macrophage M2 Polarization via C/EBP-Homologous Protein-Mediated Endoplasmic Reticulum Stress
Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Background:Aggravated liver ischemia and reperfusion (IR) injury has been observed in hyperglycemic hosts, but its underlying mechanism remains undefined. The aim of the study was…
American Transplant Congress abstracts