Articles tagged "Liver transplantation"

2015 American Transplant Congress
Combined Bone Marrow Plus Liver Transplantation in Cynomolgus Monkeys
J. Weiner, Y. Kato, R. Duran-Struuck, M. Martinez, S. Baker, P. Alonso, J. Zitsman, A. Wu, P. Houck, T. Pinyavat, J. Lefkowitch, S. Chaudhry, T. Kato, M. Sykes, A. Griesemer.
Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.
IntroductionCombined kidney/bone marrow transplantation (CKBMT) induces tolerance in both primates and humans. Since liver is thought to be more tolerogenic than kidney, we hypothesized that…
2015 American Transplant Congress
HLA-C, KIR Genotypes and KIR Genotype/HLA –C Ligand Combination in Prediction of Early Acute Rejection After Liver Transplantation
K. Park,¹ J. Ryu,¹ H. Park,³ Y. Kim,² E.-J. Oh.²
¹Biomedical Science, Graduate School, The Catholic University of Korea, Seoul, Republic of Korea; ²Laboratory Medicine, Seoul St. Mary's Hospital, the Catholic University of Korea, Seoul, Republic of Korea; ³Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Introduction; Interaction of killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen class-I (HLA-I) regulates NK cytotoxicity and function. NK regulation influences on NK/T cell alloreactivity…
2015 American Transplant Congress
In House Oxygen Persufflation of Cold Stored Livers Versus Simple Cold Storage in Extended Criteria Liver Grafts: Results of a Randomized Controlled Clinical Trial
A. Gallinat,¹ A. Paul,¹ D. Hoyer,¹ C. Klein,¹ S. Swoboda,¹ C. Ose,² Z. Mathe,¹ J. Treckmann,¹ T. Minor.³
¹Dept. of General-, Viszeral- und Transplantation Surgery, University Hospital Essen, Essen, Germany; ²Institute of Computer Science in Medicine, Biostatistics and Epidemiology, University Hospital Essen, Essen, Germany; ³Surgical Research Div., Universiy Clinic Surgery, Bonn, Germany.
Two hours of end-ischemic oxygen persufflation of cold stored porcine livers regenerates cellular energy dependent pathways and improves survival after transplantation. The present trial evaluated…
2015 American Transplant Congress
Early Recurrence of Primary Sclerosing Cholangitis After Liver Transplantation Has No Negative Impact on Patients outcome'
B. Lowry,¹ W. El Moghazy,^1,2 G. Meeberg,¹ N. Kneteman.¹
¹Hepatobiliary Pancreatic Surgery and Transplantation, University of Alberta, Edmonton, AB, Canada; ²Surgery, Sohag University, Sohag, Egypt.
Liver transplantation (LT) is the only therapeutic option for primary sclerosing cholangitis (PSC), however, recurrence of PSC (rPSC) post-LT occurs at rates ranging from 9-47%.…
2015 American Transplant Congress
Significant Reduction in TRAIL-Expressing NK Cells in Remnant Liver After Partial Hepatectomy Is Strongly Associated With the Impaired Intrahepatic CXCL9–CXCR3 Pathway
T. Yano, M. Ohira, H. Ohdan.
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima City, Japan.
Antitumor activity of liver natural killer (NK) cells decreases after partial hepatectomy or liver transplantation (LT), suggesting the susceptibility of patients with depressed immune status…
2015 American Transplant Congress
Controlled Hemodilution in Infant Liver Transplants: A Single Center Experience
T. Todo,¹ A. Gallo,¹ J. Mendoza,² T. Pham,¹ C. Esquivel.¹
¹Dept of Surgery, Stanford University, Palo Alto, CA; ²Dept of Anesthesia, Stanford University, Palo Alto, CA.
Introduction: Hepatic artery thrombosis (HAT) remains a major comorbidity in pediatric liver transplants often resulting in graft loss and mortality. Controlled hemodilution decreases blood viscosity…
2015 American Transplant Congress
Rejection Triggers Liver Transplant Tolerance: Involvement of Mesenchyma-Meidated Immune Control Mechanisms
M. Morita, D. Joyce, C. Miller, J. Fung, L. Lu, S. Qian.
Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Successful organ transplantation relies on lifelong immunosuppression, associated with severe side effects. Induction of tolerance is ideal but elusive in clinic. Indeed spontaneous liver transplant…
2015 American Transplant Congress
Real-Time Measurements of Tissue Oxygen Microtension as a Marker of Bile Duct Viability in Liver Transplantation
R. Ciria-bru, E. Navarro-Rodriguez, M. Sanchez-Frías, J. Medina-Fernandez, A. Gallardo-Herrera, M. Ayllon-Teran, S. Rufián-Peña, P. Lopez-Cillero, J. Briceño-Delgado.
General Surgery, HU Reina Sofía, Córdoba, Spain.
Aims: To evaluate bile duct viability by assessing its microvascular quality using an innovative real-time oxygen tension device by testing different areas in both donor…
2015 American Transplant Congress
Impact of Anatomic Variation and Reconstructive Technique on Complications Following Living Liver Donor Transplantation – A Report from the A2ALL Consortium
T. Baker,¹ M. Zimmerman,² B. Samstein,³ E. Pomfret,⁴ J. Pomposelli,⁴ C. Berg,⁵ N. Goodrich,⁶ B. Gillespie,⁷ J. Emond.³
¹Northwestern University, Chicago; ²University of Colorado, Denver; ³Columbia University, New York; ⁴Lahey Clinic, Burlington; ⁵Duke University, Durham; ⁶Arbor Research, Ann Arbor; ⁷University of Michigan, Ann Arbor.
Introduction: Living donor liver transplantation [LDLT] is a technically demanding endeavor that requires command of the complex anatomy of partial liver grafts. The aim of…
2015 American Transplant Congress
Combined Hepatitic/Cholangiopathic Lesion in HIV-HCV Co-Infected Liver Transplant Recipients Associated With Graft Loss
J. Harbell,¹ A. Doherty,² L. Ferrell,² B. Barin,³ N. Terrault,¹ P. Stock.¹
¹Surgery, University of California, San Francisco, San Francisco, CA; ²Pathology, University of California, San Francisco, San Francisco, CA; ³EMMES Corporation, Rockville, MD.
Background: Co-infection with HIV and viral hepatitis results in poorer outcomes following liver transplantation. In this population, complex immune status, extensive drug regimens, and comorbid…